A5081343185- Neurobiology and Insect Physiology Research
- Insect and Arachnid Ecology and Behavior
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Animal Behavior and Reproduction
- Genetics, Aging, and Longevity in Model Organisms
- Neurotransmitter Receptor Influence on Behavior
- Circadian rhythm and melatonin
- Insect Utilization and Effects
- Computational Drug Discovery Methods
- Genetics and Neurodevelopmental Disorders
- Cholinesterase and Neurodegenerative Diseases
- Neural Networks and Applications
- Epigenetics and DNA Methylation
- Epilepsy research and treatment
- Retinal Development and Disorders
- Developmental Biology and Gene Regulation
- Insect symbiosis and bacterial influences
- Plant Molecular Biology Research
- Nicotinic Acetylcholine Receptors Study
- Zebrafish Biomedical Research Applications
- Receptor Mechanisms and Signaling
- Plant and animal studies
- Autism Spectrum Disorder Research
- Stress Responses and Cortisol
Hamad bin Khalifa University
2019-2024
Duke-NUS Medical School
2015-2024
Institute of Molecular and Cell Biology
2015-2024
Agency for Science, Technology and Research
2016-2024
Indian Institute of Technology Guwahati
2022
Tata Institute of Fundamental Research
2009-2021
Sultan Agung Islamic University
2021
University of Anbar
2020
Health & Life (Taiwan)
2019
Khalifa University of Science and Technology
2019
Ayurveda is an ancient system of personalized medicine documented and practiced in India since 1500 B.C. According to this individual's basic constitution a large extent determines predisposition prognosis diseases as well therapy life-style regime. describes seven broad types (Prakritis) each with varying degree different diseases. Amongst these, three most contrasting types, Vata, Pitta, Kapha, are the vulnerable In realm modern predictive medicine, efforts being directed towards capturing...
Anxiety helps us anticipate and assess potential danger in ambiguous situations [1-3]; however, the anxiety disorders are most prevalent class of psychiatric illness [4-6]. Emotional states shared between humans other animals [7], as observed by behavioral manifestations [8], physiological responses [9], gene conservation [10]. research makes wide use three rodent assays-elevated plus maze, open field, light/dark box-that present a choice sheltered exposed regions [11]. Exposure avoidance...
Pancreatic cancer is a very deadly disease with 5-year survival rate, making it one of the leading causes cancer-related deaths globally. Focal adhesion kinase 1 (FAK1) ubiquitously expressed protein in pancreatic cancer. FAK, tyrosine that overexpressed cells, crucial for development tumors into malignant phenotypes. FAK functions response to extracellular signals by triggering transmembrane receptor signaling, which enhances focal turnover, cell adhesion, migration, and gene expression....
Psychedelic compounds that target the 5-HT2A receptor are reported to evoke psychoplastogenic effects, including enhanced dendritic arborization and synaptogenesis. Transcriptional regulation of neuronal plasticity-associated genes is implicated in cytoarchitectural effects serotonergic psychedelics, however, transcription factors drive this poorly elucidated. Here, we addressed contribution factor cyclic adenosine monophosphate (cAMP)-response element binding protein (CREB) by...
Abstract Background Crimean-Congo hemorrhagic fever (CCHF) is a widespread disease transmitted to humans and livestock animals through the bite of infected ticks or close contact with persons’ blood, organs, other bodily fluids. The virus responsible for severe viral outbreaks, case fatality rate up 40%. Despite having highest virus, suitable treatment option vaccination has not been developed yet. Therefore, this study aimed formulate multiepitope vaccine against CCHF computational design...
In animals, commensal microbes modulate various physiological functions, including behavior. While microbiota exposure is required for normal behavior in mammals, it not known how widely this dependency present other animal species. We proposed the hypothesis that microbiome has a major influence on of vinegar fly (Drosophila melanogaster), invertebrate model organism. Several assays were used to test contribution some well-characterized behaviors: defensive behavior, sleep, locomotion, and...
Optical silencing of activity provides a way to test the necessity neurons in behaviour. Two light-gated anion channels, GtACR1 and GtACR2, have recently been shown potently inhibit cultured mammalian Drosophila. Here, we usefulness these channels larval zebrafish, using spontaneous coiling behaviour as assay. When GtACRs were expressed spinal embryonic zebrafish actuated with blue or green light, movement was inhibited. In GtACR1-expressing fish, only 3 μW/mm2 light sufficient an effect;...
Merkel cell carcinoma (MCC) is a rare neuroendocrine skin malignancy caused by human polyomavirus (MCV), leading to the most aggressive cancer in humans. MCV has been identified approximately 43%–100% of MCC cases, contributing highly nature primary cutaneous and notable mortality rate. Currently, no existing vaccines or drug candidates have shown efficacy addressing ailment this specific pathogen. Therefore, study aimed design novel multiepitope vaccine candidate against virus using...
Abstract Background In light of several recent studies, there is evidence that the coronavirus disease 2019 (COVID-19) pandemic has caused various mental health concerns in general population, as well among healthcare workers (HCWs). The main aim this study was to assess psychological distress, burnout and structural empowerment status HCWs during COVID-19 outbreak, evaluate its predictors. Methods This multi-center, cross-sectional web-based questionnaire survey conducted on outbreak from...
The analysis of behavior requires that the underlying neuronal circuits are identified and genetically isolated. In several major model species—most notably Drosophila—neurogeneticists identify isolate neural with a binary heterologous expression-control system: Gal4–UASG. One limitation Gal4–UASG is expression patterns often too broad to map precisely. To help refine range Gal4 lines, we developed an intersectional genetic AND operator. Interoperable Gal4, new system's key component fusion...
Rodent kindling induced by PTZ is a widely used model of epileptogenesis and AED testing. Overlapping pathophysiological mechanisms may underlie other neuropsychiatric conditions. Besides epilepsy, AEDs are in treating various disorders. Mechanisms AEDs' long term action these disorders poorly understood. We describe here Drosophila systems locomotor plasticity that responsive to AEDs.We empirically determined regime which seven days treatment subsequent discontinuation respectively cause...
Symptoms secondary to hormonal changes significantly impact quality of life (QoL) in patients with cancer. This cross-sectional study examines prevalence hypogonadism and its correlation QoL sexual dysfunction.We collected blood medical histories from 428 male non-testosterone-related cancer at three centers. Serum was analyzed for total testosterone (TT), free (FT), bioavailable (BAT), sex hormone binding globulin (SHBG). The Functional Assessment Cancer Therapy-Prostate (FACT-P)...
The BRAF gene is responsible for transferring signals from outside of the cell to inside nucleus by converting a protein namely B-Raf through RAS/MAPK pathway. This pathway contribute division, proliferation, migration, and apoptotic death human animal. Mutation in this may cause development several cancers, including lung, skin, colon, neuroblastoma. Currently, few available drugs are being used that has developed targeting mutated protein, due toxic side effects, patients suffer lot during...
Monoamines are implicated in the modulation of adult hippocampal neurogenesis depression models and following chronic antidepressant treatment. Given key role Sonic hedgehog (Shh) neurogenesis, we examined whether monoaminergic perturbations regulate expression Shh or its co-receptors Smoothened (Smo) Patched (Ptc). Combined depletion both serotonin norepinephrine with para-chlorophenylalanine (PCPA) resulted a significant decrease Smo Ptc mRNA within dentate gyrus subfield hippocampus....
Genetic studies in Drosophila reveal that olfactory memory relies on a brain structure called the mushroom body. The mainstream view is each of three lobes body play specialized roles short-term aversive memory, but number have made divergent conclusions based their varying experimental findings. Like many fields, neurogenetics uses null hypothesis significance testing for data analysis. Critics claim this method promotes discrepancies by using arbitrary thresholds (α) to apply reject/accept...
Abstract Rodent defense behavior assays have been widely used as preclinical models of anxiety to study possibly therapeutic anxiety-reducing interventions. However, some proposed anxiety-modulating factors—genes, drugs and stressors—have had discordant effects across different studies. To reconcile the effect sizes purported factors, we conducted systematic review meta-analyses literature on ten anxiety-linked interventions, examined in elevated plus maze, open field light-dark box assays....