Ganesan Karthikeyan
A5003441894- Cardiac Imaging and Diagnostics
- Infective Endocarditis Diagnosis and Management
- Streptococcal Infections and Treatments
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
- Radiation Dose and Imaging
- Cardiac, Anesthesia and Surgical Outcomes
- Antimicrobial Resistance in Staphylococcus
- Advanced X-ray and CT Imaging
- Antiplatelet Therapy and Cardiovascular Diseases
- Ultrasound in Clinical Applications
- Folate and B Vitamins Research
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Advanced MRI Techniques and Applications
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Global Maternal and Child Health
- Hemodynamic Monitoring and Therapy
- Advanced NMR Techniques and Applications
- Health disparities and outcomes
All India Institute of Medical Sciences
2016-2025
Amity University
2019-2024
Institut de Chimie Radicalaire
2021-2024
Aix-Marseille Université
2020-2024
Translational Health Science and Technology Institute
2024
Centre National de la Recherche Scientifique
2009-2024
George Institute for Global Health
2024
Stanford University
2024
Tamil Nadu Agricultural University
2022-2024
Karpagam Academy of Higher Education
2024
Rheumatic heart disease remains an important preventable cause of cardiovascular death and disability, particularly in low-income middle-income countries. We estimated global, regional, national trends the prevalence mortality due to rheumatic as part 2015 Global Burden Disease study.We systematically reviewed data on fatal nonfatal for period from 1990 through 2015. Two analytic tools, Cause Death Ensemble model DisMod-MR 2.1, were used produce estimates prevalence, including uncertainty.We...
Rheumatic heart disease (RHD) accounts for over a million premature deaths annually; however, there is little contemporary information on presentation, complications, and treatment.This prospective registry enrolled 3343 patients (median age 28 years, 66.2% female) presenting with RHD at 25 hospitals in 12 African countries, India, Yemen between January 2010 November 2012. The majority (63.9%) had moderate-to-severe multivalvular complicated by congestive failure (33.4%), pulmonary...
Background: There are few contemporary data on the mortality and morbidity associated with rheumatic heart disease or information their predictors. We report 2-year follow-up of individuals from 14 low- middle-income countries in Africa Asia. Methods: Between January 2010 November 2012, we enrolled 3343 patients 25 centers followed them for 2 years to assess mortality, congestive failure, stroke transient ischemic attack, recurrent acute fever, infective endocarditis. Results: Vital status...
Testing of factor Xa inhibitors for the prevention cardiovascular events in patients with rheumatic heart disease-associated atrial fibrillation has been limited. We enrolled and echocardiographically documented disease who had any following: a CHA2DS2VASc score at least 2 (on scale from 0 to 9, higher scores indicating risk stroke), mitral-valve area no more than cm2, left spontaneous echo contrast, or thrombus. Patients were randomly assigned receive standard doses rivaroxaban...
Mild reaction conditions are the advantage of title reaction, which allows straightforward entry to a variety ynamides starting from readily available 1,1-dibromo-1-alkenes, act as attractive alkynylating agents (see scheme; EWG = electron-withdrawing group, DMF N,N-dimethylformamide).
Epigenetic modifications, especially alteration in DNA methylation, are increasingly being recognized as a key factor the pathogenesis of complex disorders, including atherosclerosis. However, there limited data on epigenetic changes coronary artery disease (CAD) patients. In present study we evaluated methylation status genomic from peripheral lymphocytes cohort 287 individuals: 137 angiographically confirmed CAD patients and 150 controls. The differential susceptibility to...
AimsTo characterize patient radiation doses from nuclear myocardial perfusion imaging (MPI) and the use of radiation-optimizing ‘best practices’ worldwide, to evaluate relationship between laboratory best practices dose.
The risk of stroke in patients with non-valvular atrial fibrillation (NVAF) varies widely depending on patient age and the presence other factors such as hypertension, diabetes mellitus, congestive heart failure or prior transient ischaemic attack (TIA) (1, 2). Warfarin reduces by about twothirds when compared to placebo no treatment, two-fifths aspirin, but substantially increases major bleeding (2, 3). most feared complication warfarin is intracranial which occurs at rate 2–5 per 1,000...
Acute rheumatic fever (ARF) and heart disease (RHD) remain major causes of failure, stroke death among African women children, despite being preventable imminently treatable.From 21 to 22 February 2015, the Social Cluster Africa Union Commission (AUC) hosted a consultation with RHD experts convened by Pan-African Society Cardiology (PASCAR) in Addis Ababa, Ethiopia, develop 'roadmap' key actions that need be taken governments eliminate ARF eradicate Africa.Seven priority areas for action...
Due to their combined stability and peculiar reactivity, ynamides have emerged as remarkably useful building blocks for chemical synthesis. The development of general robust methods preparation resulted in a massive interest chemistry. This notably the incredibly efficient processes starting from these which also recently found various applications medicinal chemistry natural product Our efforts contributions ynamides, we developed several reactions both use synthesis, are overviewed this...
### What you need to know Options for the secondary prevention of stroke in patients younger than 60 years who have had a cryptogenic ischaemic thought be patent foramen ovale (PFO) include PFO closure (with antiplatelet therapy), therapy alone, or anticoagulants. International guidance and practice differ on which option is preferable. The BMJ Rapid Recommendations panel used linked systematic review1 triggered by three large randomised trials published September 2017 that suggested might...