Charles Mondo
A5076694100- Blood Pressure and Hypertension Studies
- Sodium Intake and Health
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular Function and Risk Factors
- Acute Ischemic Stroke Management
- Heart Failure Treatment and Management
- Hormonal Regulation and Hypertension
- Nutritional Studies and Diet
- Global Public Health Policies and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Obesity, Physical Activity, Diet
- Dialysis and Renal Disease Management
- Streptococcal Infections and Treatments
- Lipoproteins and Cardiovascular Health
- Eicosanoids and Hypertension Pharmacology
- Acute Myocardial Infarction Research
- Birth, Development, and Health
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Liver Disease Diagnosis and Treatment
- Heart Rate Variability and Autonomic Control
- Cerebrovascular and Carotid Artery Diseases
- Viral Infections and Immunology Research
Makerere University
2013-2024
Mulago Hospital
2014-2024
Leeds Teaching Hospitals NHS Trust
2022-2023
University of Leeds
2022-2023
Nsambya Hospital
2018-2022
Ollscoil na Gaillimhe – University of Galway
2017
Vlaams Instituut voor Biotechnologie
2017
University Hospital Galway
2017
Medical University of Warsaw
2017
Institute of Psychiatry and Neurology
2017
Most data on mortality and prognostic factors in patients with heart failure come from North America Europe, little information other regions. Here, the International Congestive Heart Failure (INTER-CHF) study, we aimed to measure at 1 year Africa, China, India, Middle East, southeast Asia South America; also explored demographic, clinical, socioeconomic variables associated mortality.We enrolled consecutive (3695 [66%] clinic outpatients, 2105 [34%] hospital patients) 108 centres six...
Tuberculous pericarditis is associated with high morbidity and mortality even if antituberculosis therapy administered. We evaluated the effects of adjunctive glucocorticoid Mycobacterium indicus pranii immunotherapy in patients tuberculous pericarditis.Using a 2-by-2 factorial design, we randomly assigned 1400 adults definite or probable to either prednisolone placebo for 6 weeks M. placebo, administered five injections over course 3 months. Two thirds participants had concomitant human...
BackgroundThe 2016 Dar Es Salaam Call to Action on Diabetes and Other non-communicable diseases (NCDs) advocates national multi-sectoral NCD strategies action plans based available data information from countries of sub-Saharan Africa beyond. We estimated trends 1980 2014 in age-standardized mean body mass index (BMI) diabetes prevalence these countries, order assess the co-progression assist policy formulation.
The prevalence of hypertension among black African patients is high, and these usually need two or more medications for blood-pressure control. However, the most effective two-drug combination that currently available control in has not been established.
Acute rheumatic fever (ARF) and heart disease (RHD) remain major causes of failure, stroke death among African women children, despite being preventable imminently treatable.From 21 to 22 February 2015, the Social Cluster Africa Union Commission (AUC) hosted a consultation with RHD experts convened by Pan-African Society Cardiology (PASCAR) in Addis Ababa, Ethiopia, develop 'roadmap' key actions that need be taken governments eliminate ARF eradicate Africa.Seven priority areas for action...
Symptoms of sleep disturbance are common and may represent important modifiable risk factors stroke. We evaluated the association between a spectrum symptoms acute stroke in an international setting.The INTERSTROKE study is case-control patients presenting with first controls matched by age (±5 years) sex. Sleep previous month were assessed through questionnaire. Conditional logistic regression estimated stroke, expressed as odds ratios (ORs) 95% CIs. The primary model adjusted for age,...
Stroke is a major global health problem. It the third leading cause of death and adult disability. INTERHEART, case-control study acute myocardial infarction in 52 countries (29,972 participants), identified nine modifiable risk factors that accounted for >90% population-attributable risk. However, traditional (e.g. hypertension, cholesterol) appear to exert contrasting risks stroke compared with coronary heart disease, etiology far more heterogeneous. In addition, our knowledge...
Chronic kidney disease (CKD) is a major cause of morbidity and mortality in Sub-Saharan Africa (SSA). The majority studies on CKD SSA have been conducted among HIV-infected populations mainly from large health facilities. We determined the prevalence its predictors communities central Uganda. A cross-sectional study was Wakiso district using multi-stage sampling. Data collected age, sex, socio-economic status, history alcohol intake, diabetes mellitus, hypertension smoking. Measurement blood...
Background: To date there has been no population-based survey of the major risk factors for non-communicable diseases (NCD) in Uganda.Hospital-based data from urban centres report an increasing burden NCDs Uganda.This aimed to describe prevalence a rural Ugandan district.Methods: The was conducted using WHO STEPwise approach surveillance (STEPS) methodology.Participants (n = 611) were residents Kasese district selected one-step, complete district.Standardised international protocols used...
<strong>Background:</strong> A wide knowledge gap exists on the clinical profiles and outcomes of heart failure (HF) in sub-Saharan Africa. <strong>Objectives:</strong> To determine HF patients from five African countries. <strong>Methods:</strong> The INTERnational Congestive Heart Failure Study (INTER-CHF) is a prospective, multicenter cohort study. total 1,294 were consecutively recruited Nigeria (383 patients), South Africa (169 Sudan (501 Uganda (151patients), Mozambique (90 patients)....
The association of dyslipidemia with stroke has been inconsistent, which may be due to differing associations within etiological subtypes. We sought determine the lipoproteins and apolipoproteins subtypes.Standardized incident case-control STROKE study in 32 countries. Cases were patients acute hospitalized first stroke, matched by age, sex site controls. Concentrations total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density (LDL-C), apolipoprotein A1 (apoA1), apoB...
Importance Psychosocial stress is considered a modifiable risk factor for stroke. Given the prevalence of chronic and acute exposure to stress, it represents potentially attractive target population-health interventions. Objectives To determine association psychosocial with stroke explore factors that might modify in large international population. Design, Setting, Participants INTERSTROKE an retrospective case-control study first 32 countries Asia, North South America, Europe, Australia,...
Smoking is a major risk factor for the global burden of stroke. We have previously reported population attributable (PAR) stroke 12.4% associated with current smoking. In this study we aimed to explore association tobacco use different types exposure and environmental smoke (ETS) on subtypes, by regions country income levels.
Introduction: Rheumatic heart disease (RHD) frequently occurs following recurrent episodes of acute rheumatic fever (ARF).Benzathine penicillin (benzapen) is the most effective method for secondary prophylaxis against ARF whose efficacy largely depends on adherence to treatment.Various factors determine therapy but there are no data regarding current use benzapen in patients with RHD attending Mulago Hospital.The study aims were (1) levels among Hospital, and (2) establish patient associated...
Influenza is associated with an increase in the risk of cardiac and other vascular events. Observational data small randomized trials suggest that influenza vaccination may reduce such adverse
Objective Hypertension is the most important modifiable risk factor for stroke globally. We hypothesised that country-income level variations in knowledge, detection and treatment of hypertension may contribute to association blood pressure with stroke. Methods undertook a standardised case-control study 32 countries (INTERSTROKE). Cases were patients acute first (n=13 462) who matched by age, sex site controls 483). evaluated associations awareness its subtypes whether this varied gross...
Background: The contribution of atrial fibrillation (AF) to the etiology and burden stroke may vary by country income level. Aims: We examined differences in prevalence AF described variations magnitude association between ischemic Methods: In INTERSTROKE case–control study, participants with acute first were recruited across 32 countries. included 10,363 cases 10,333 community or hospital controls who matched for age, sex, center. Participants grouped into high-income (HIC),...
Abstract The May Measurement Month (MMM) campaign was carried out in Uganda 2022 with the aim of raising awareness raised blood pressure (BP). Here, we report on findings campaign. Adults aged ≥ 18 years were recruited opportunistically at St Francis Hospital, Nsambya and Kiruddu National Referral Hospital Kampala. Three seated BP readings taken for each participant, along completion a questionnaire demographics, lifestyle factors, comorbidities. Hypertension defined as systolic 140 mmHg...