A5052790698- Blood Pressure and Hypertension Studies
- Hormonal Regulation and Hypertension
- Sodium Intake and Health
- Dialysis and Renal Disease Management
- Ion Transport and Channel Regulation
- Pharmacogenetics and Drug Metabolism
- Cardiac Imaging and Diagnostics
- Acute Kidney Injury Research
- Pregnancy and preeclampsia studies
- Global Public Health Policies and Epidemiology
- Acute Myocardial Infarction Research
- Cardiovascular Health and Risk Factors
- Health Systems, Economic Evaluations, Quality of Life
- Heart Failure Treatment and Management
- Cardiovascular Function and Risk Factors
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Disease Prevention
- Electrolyte and hormonal disorders
- Birth, Development, and Health
- Heart Rate Variability and Autonomic Control
- Medication Adherence and Compliance
- Pharmacological Effects and Toxicity Studies
- Lipoproteins and Cardiovascular Health
- HIV/AIDS drug development and treatment
- Cardiac Valve Diseases and Treatments
Groote Schuur Hospital
2015-2025
University of Cape Town
2016-2025
Cedars-Sinai Medical Center
2012-2024
South African Medical Research Council
2023-2024
University of Wyoming
2023
Hypertension Institute
2019-2023
Institute of Cardiology
2022
Norwegian Institute of Public Health
2022
University of New Mexico
2022
International Society of Hypertension
2021
Raised blood pressure (BP) is the leading cause of preventable death in world. Yet, its global prevalence increasing, and it remains poorly detected, treated, controlled both high- low-resource settings. From perspective members International Society Hypertension based all regions, we reflect on past, present, future hypertension care, highlighting key challenges opportunities, which are often region-specific. We report that most countries failed to show sufficient improvements BP control...
The prevalence of hypertension among black African patients is high, and these usually need two or more medications for blood-pressure control. However, the most effective two-drug combination that currently available control in has not been established.
African and American hypertensives tend to retain salt water, with lower levels of plasma renin more resistant hypertension. We tested the hypothesis that physiological phenotyping aldosterone would improve blood pressure control in uncontrolled Africa.
Abstract OBJECTIVES Black subjects tend to retain salt and water, be more sensitive aldosterone, have suppression of plasma renin activity. Variants the renal sodium channel (ENaC, SCNN1B) account for approximately 6% resistant hypertension (RHT) in Blacks; other candidate genes may important. METHODS Six associated with low renin-resistant were sequenced Africans from clinics Kenya South Africa. CYP11B2 was if aldosterone level high (primary aldosteronism phenotype); SCNN1B, NEDD4L, GRK4,...
Spot urine samples with estimating equations have been used to assess individuals’ sodium (salt) intake in association health outcomes. There is large random and systematic error using this method spurious outcome associations. Substantial controversy has resulted from false claims the valid. Hence, World Hypertension League, International Society of Resolve Save Lives, supported by 21 other organizations, issued policy statement that strongly recommends research spot outcomes should not be...
Methamphetamine abuse has risen dramatically in South Africa. The chronic effects of on the kidneys and blood pressure have not been documented. This study reviewed patients referred for evaluation kidney disease and/or hypertension, who had abusing methamphetamines.The records to renal unit between 2005 2013 using methamphetamines were retrospectively reviewed. Patient demographics, biophysical parameters, pressure, function, ultrasound biopsy findings, complications comorbidities...
A core feature of universal health coverage is equitable access to affordable care not exposing people financial hardship. This study aims provide a global overview on availability and medications technologies for delivery optimal kidney care. An international survey stakeholders (clinicians, policymakers, patient advocates) from countries affiliated the International Society Nephrology was conducted July September 2022 tools services all aspects essential medications. Of 167 participating...
Abstract The May Measurement Month (MMM) campaign was carried out in South Africa 2022 with the aim of raising awareness raised blood pressure (BP). Here, we report on findings campaign. Adults aged ≥ 18 years were recruited opportunistically at university campuses, community centres, schools, sport complexes, public parks, shopping hospitals, and through household visits. Three seated BP readings taken for each participant, along completion a questionnaire demographics, lifestyle factors,...
The epithelial sodium channel (ENaC) may be a common underlying pathway for the development of primary hypertension. In South Africa, R563Q variant ENaC is associated with low-renin-low-aldosterone hypertension and preeclampsia in black Africans mixed-ancestry peoples. purpose this study was to investigate prevalence multiethnic populations its association response amiloride patients resistant Samples were obtained from hypertensives normotensive controls Cape Town Johannesburg, unselected...
A robust human challenge model for Campylobacter jejuni is an important tool the evaluation of candidate vaccines. The previously established conveys a potential risk Guillain-Barré syndrome attributable to lipooligosaccharide ganglioside mimicry. This work establishes new C. that uses strain (CG8421) without mimicry and applies Campylobacter-specific cellular immunity screening achieve high attack rates at lower inoculum doses.Healthy Campylobacter-naive adults participated in open-label...
Background: A high prevalence of the R563Q mutation epithelial sodium channel β-subunit has been reported in South African hypertensives compared with unrelated normotensive controls.To delineate effects this against a more uniform genetic background, study investigated association hypertension within affected kindreds.Methods: Forty-five index patients and members their kindreds were studied.Blood pressure, serum potassium presence determined.Results: Of 136 individuals studied, 89...
End Stage Kidney Disease (ESKD) is a public health problem with an enormous economic burden. In resource limited settings management of ESKD often rationed. Racial and socio-economic inequalities in selecting candidates have been previously documented South Africa. New guidelines for dialysis developed the Western Cape focused on prioritizing treatment. With this mind we aimed at exploring whether new would improve documented. A retrospective study patients presented to selection committee...
Sub-Saharan Africa remains challenged by the highest burden of human immunodeficiency virus (HIV), an epidemic tuberculosis (TB), and increasing number people with HIV (PWH) on antiretroviral therapy (ART), all which may result in kidney injury.This observational cohort study describes spectrum disease PWH South Africa, between 2005 2020. Kidney biopsies were analyzed 4 time periods as follows: early ART rollout (2005-2009), tenofovir disoproxil (TDF) introduction (2010-2012), TDF-based...
Angina, heart failure with preserved ejection fraction (HFpEF) and coronary microvascular dysfunction (CMD) in the absence of obstructive artery disease (CAD) are more common women associated adverse cardiovascular prognosis. Cardiac magnetic resonance imaging (CMRI) is established for assessment left ventricular (LV) morphology systolic function increasingly used to assess myocardial perfusion diastolic function. Indeed, stress CMRI allows measurement reserve index (MPRI) using...
Abstract Background Dipping of blood pressure (BP) at night is a normal physiological phenomenon. However, non-dipping pattern associated with hypertension mediated organ damage, secondary forms and poorer long-term outcome. Identifying may be useful in assessing risk, aiding the decision to investigate for causes, initiating treatment, assisting decisions on choice timing antihypertensive therapy, intensifying salt restriction. Objectives To estimate prevalence factors determine effect 6...
ABSTRACT South Africa continues to be burdened by human immunodeficiency virus (HIV) and tuberculosis (TB). In Cape Town, the epidemic of HIV‐TB co‐infection is as high 70%. Granulomatous interstitial nephritis (GIN) has increased in frequency on renal biopsy. This study aimed determine GIN prevalence causes HIV‐positive patients well outcomes, patient survival associated factors. observational cohort reviewed biopsies for from 2005 2012. Causes (medications, TB, fungal other), baseline...
The antihypertensive effect and tolerance of the combined low doses felodipine enalapril (5 + 5 mg daily) were compared with those either drug at a higher dose level (10 daily). Our double-blind, three-way crossover study (balanced Latin square design) involved 36 elderly subjects (mean age 67 ± 6 years) essential hypertension. After 4-week placebo run-in phase randomized to active treatment periods, starting plus enalapril, felodipine, or daily for first 4 weeks. in periods then doubled...