A5059445528- Chronic Obstructive Pulmonary Disease (COPD) Research
- HIV/AIDS drug development and treatment
- Tuberculosis Research and Epidemiology
- Renal Diseases and Glomerulopathies
- Pneumocystis jirovecii pneumonia detection and treatment
- Nephrotoxicity and Medicinal Plants
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Diagnosis and treatment of tuberculosis
- Mycobacterium research and diagnosis
- Infectious Diseases and Tuberculosis
- Pediatric health and respiratory diseases
- Respiratory viral infections research
- COVID-19 and Mental Health
- Asthma and respiratory diseases
- Herpesvirus Infections and Treatments
- Pituitary Gland Disorders and Treatments
- Infection Control and Ventilation
- Airway Management and Intubation Techniques
- Sarcoidosis and Beryllium Toxicity Research
- Neuroendocrine Tumor Research Advances
- Data-Driven Disease Surveillance
- Smoking Behavior and Cessation
- Innovations in Medical Education
- Cytomegalovirus and herpesvirus research
- Pneumonia and Respiratory Infections
University of Oxford
2024
Oxford University Clinical Research Unit
2024
Groote Schuur Hospital
2009-2023
University of Cape Town
2019-2023
Somerset Hospital
2022-2023
Sub-Saharan Africa remains challenged by the highest burden of human immunodeficiency virus (HIV), an epidemic tuberculosis (TB), and increasing number people with HIV (PWH) on antiretroviral therapy (ART), all which may result in kidney injury.This observational cohort study describes spectrum disease PWH South Africa, between 2005 2020. Kidney biopsies were analyzed 4 time periods as follows: early ART rollout (2005-2009), tenofovir disoproxil (TDF) introduction (2010-2012), TDF-based...
ABSTRACT South Africa continues to be burdened by human immunodeficiency virus (HIV) and tuberculosis (TB). In Cape Town, the epidemic of HIV‐TB co‐infection is as high 70%. Granulomatous interstitial nephritis (GIN) has increased in frequency on renal biopsy. This study aimed determine GIN prevalence causes HIV‐positive patients well outcomes, patient survival associated factors. observational cohort reviewed biopsies for from 2005 2012. Causes (medications, TB, fungal other), baseline...
To describe the spectrum of kidney disease in African patients with HIV and tuberculosis (TB).We used data from three cohorts: consecutive HIV/TB South London (UK, 2004-2016; n = 95), who underwent biopsy Cape Town (South Africa, 2014-2017; 70), found to have on autopsy Abidjan (Cote d'Ivoire, 1991; 100). Acute injury (AKI) was ascertained using Kidney Disease: Improving Global Outcomes (KDIGO) criteria. In cohort, predictors recovery function at 6 months were assessed Cox regression.In...
We characterized the spatial distribution of drug-susceptible (DS) and multidrug-resistant (MDR) tuberculosis (TB) cases in Ho Chi Minh City, Vietnam, a major metropolis southeastern Asia, explored demographic socioeconomic factors associated with local TB burden. Hot spots DS MDR incidence were observed central parts substantial heterogeneity was across wards. Positive autocorrelation for both TB. Ward-level HIV prevalence male proportion population. No ward-level indicators case count...
Abstract Tuberculosis remains a global health problem. Making it easier and quicker to identify which antibiotics an infection is likely be susceptible will key part of the solution. Whilst whole-genome sequencing offers many advantages, processing genetic reads produce relevant public clinical information is, surprisingly, often responsibility end user inhibits uptake. Here we describe our Mycobacterial genetics pipeline its deployment in cloud-based platform. For antibiotic resistance...
IntroductionSouth Africa has the highest prevalence of HIV in world. The epidemiology kidney disease among people with infections is well-described United States. However, there are limited data coming from South Africa, particularly that involve biopsies. purpose this study was to determine what, if any, patient factors predictive HIV-associated nephropathy (HIVAN) on biopsy a African cohort.MethodsThis prospectively collected all patients infected referred Groote Schuur Hospital (GSH)...
Background. Near-peer teaching (NPT) programmes may benefit both student learners (SLs) and near-peer tutors (NTs). However, data evaluating NPT in developing countries such as South Africa are lacking. Objectives. To evaluate the efficacy of an programme improving knowledge confidence SLs NTs, to perceptions programme. Methods. An which clinical year students provided tutorials pre-clinical was developed. Participants completed a knowledge-assessing multiple-choice questionnaire (MCQ)...
Background: Evidence-based Infection Prevention and Control (IPC) measures are critical in protecting medical doctors from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Concerns surrounding access to personal protective equipment (PPE), compliance with IPC the quality of available PPE have been raised as possible causes for high rates SARS-CoV-2 infection transmission settings. This study aimed determine prevalence risk factors occupational hospitals Nelson Mandela...
Cytomegalovirus (CMV) infection is common in people living with HIV, but multisystem CMV end-organ disease (EOD) rare following the introduction of effective antiretroviral therapy. We present case a patient advanced HIV and manifestations EOD.This report highlights potential morbidity mortality associated patients HIV. Clinicians should be vigilant considering EOD visual, neurological gastointestinal symptoms.
Asthma is one of the most common coexisting diseases in children, and a major cause mortality morbidity children. Morbidity measured by school absences, emergency department visits hospitalisations. continues to take lives children at an alarming rate there evidence that its has increased over last 20 years. severity with urbanisation exposure cigarette smoke. Proper diagnosis, education, appropriate management are essential decrease mortality.This review article provides understanding...
South Africa continues to be burdened by human immunodeficiency virus [HIV] and tuberculosis [TB]. In Cape Town, the epidemic of HIV-TB co-infection is as high 70%. Granulomatous interstitial nephritis [GIN] has increased in frequency on renal biopsy. This study aimed determine GIN prevalence causes HIV positive patients well outcomes, patient survival associated factors.
Background: Patients with HIV and drug-resistant tuberculosis (TB) are at high risk of death.Objectives: We investigated the association between rifampicin-resistant TB (RR-TB) mortality in a cohort patients who were admitted to hospital time diagnosis.Method: Adults hospitalised Khayelitsha Hospital diagnosed HIV-associated during admission, enrolled 2013 2016. Clinical, biochemical microbiological data prospectively collected participants followed up for 12 weeks.Results: Participants...