A5063294371- Antibiotics Pharmacokinetics and Efficacy
- Blood Pressure and Hypertension Studies
- Tuberculosis Research and Epidemiology
- Drug Transport and Resistance Mechanisms
- Sodium Intake and Health
- HIV/AIDS drug development and treatment
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Phenothiazines and Benzothiazines Synthesis and Activities
- Analytical Methods in Pharmaceuticals
- Malaria Research and Control
- Hormonal Regulation and Hypertension
- Pneumonia and Respiratory Infections
- Ophthalmology and Visual Health Research
- Drug-Induced Hepatotoxicity and Protection
- Heart Rate Variability and Autonomic Control
- Pharmaceutical Economics and Policy
- Plant Virus Research Studies
- Viral gastroenteritis research and epidemiology
- Epilepsy research and treatment
- Complement system in diseases
- Pneumocystis jirovecii pneumonia detection and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Cellular transport and secretion
- Cancer therapeutics and mechanisms
Life Groenkloof Hospital
2023
University of Cape Town
2007-2022
Clinical Research Management
2019
The prevalence of hypertension among black African patients is high, and these usually need two or more medications for blood-pressure control. However, the most effective two-drug combination that currently available control in has not been established.
The currently recommended doses of rifampin are believed to be at the lower end dose-response curve. Rifampin induces its own metabolism, although effect dose on extent autoinduction is not known. This study aimed investigate using a semimechanistic pharmacokinetic-enzyme turnover model. Four different structural basic models were explored assess whether scaling methods affected final covariate selection procedure. Covariates selected by linearized approach. model included allometric oral...
The intra-erythrocytic stages of the malaria parasite endocytose large quantities surrounding erythrocyte cytoplasm and deliver it to a digestive food vacuole via endocytic vesicles. Digestion provides amino acids for protein synthesis is required maintain osmotic integrity host cell. pathway has been described morphologically by electron microscopy, but molecular mechanisms that mediate regulate remain elusive. Given involvement actin in endocytosis other eukaryotes, we have used inhibitors...
Abstract Background Gatifloxacin is used for the treatment of multidrug-resistant tuberculosis (MDR-TB). The optimal dose unknown. Methods We performed a 28-day gatifloxacin hollow-fiber system model (HFS-TB) study in order to identify target exposures associated with kill rates and resistance suppression. Monte Carlo experiments (MCE) were that would achieve exposure 10000 adult patients meningeal or pulmonary MDR-TB. doses identified validated using probit analyses clinical data from 2...
Rifampicin (RMP) drives treatment response in drug-susceptible tuberculosis. Low RMP concentrations increase the risk of poor outcomes, and drug quality needs to be excluded as a contributor low exposure.We performed an open-label, three-way cross-over study three licensed RMP-containing formulations widely used South Africa evaluate bioavailability two-drug fixed-dose combination tablet (2FDC) four-drug FDC (4FDC) against single-drug reference. dosed at 600 mg was administered 2 weeks apart...
In the experimental arm of OFLOTUB trial, gatifloxacin replaced ethambutol in standard 4-month regimen for drug-susceptible pulmonary tuberculosis. The study included a nested pharmacokinetic (PK) study. We sought to determine if PK variability played role patient outcomes.
ABSTRACT A 4-month regimen of gatifloxacin with rifampin, isoniazid, and pyrazinamide is being evaluated for the treatment tuberculosis in a phase 3 randomized controlled trial (OFLOTUB). prior single-dose study found that exposure increased by 14% combination. The aims are to evaluate initial steady-state pharmacokinetics when daily doses given patients newly diagnosed drug-sensitive pulmonary as part combination dose respect probability attaining pharmacokinetic/pharmacodynamic target. We...
Darunavir/ritonavir is better tolerated than lopinavir/ritonavir and has a higher genetic barrier to resistance. Co-administration with rifampicin been contraindicated as significant reduction in darunavir exposure expected. This darunavir/ritonavir use where TB endemic.To evaluate the safety pharmacokinetic profile of adjusted doses rifampicin.Virally suppressed participants on second-line lopinavir/ritonavir-based ART were switched 800/100 mg q24h. In sequence: was added; dose ritonavir...
We sought to address the paucity of data support evidence-based management hypertension achieve optimal blood pressure (BP) control on a sex-specific basis in Africa.We undertook post hoc analysis multicenter, randomized CREOLE (Comparison Three Combination Therapies Lowering Blood Pressure Black Africans) Trial test hypothesis that there would be clinically important differences office BP between African men and women. compared levels 397 238 hypertensive women (63%, 50.9 ± 10.5 years)...
Background: The effect of 3 commonly recommended combinations anti-hypertensive agents—amlodipine plus hydrochlorothiazide (calcium channel blocker [CCB]+thiazide), amlodipine perindopril (CCB+ACE [angiotensin-converting enzyme]-inhibitor), and (ACE-inhibitor+thiazide) on blood pressure variability (V) are unknown. Methods: We calculated the (BPV) in 405 patients (130, 146, 129 randomized to ACE-inhibitor+thiazide, CCB+thiazide, CCB+ACE-inhibitor, respectively) who underwent ambulatory...