A5101930940- Advanced MRI Techniques and Applications
- Cardiac Imaging and Diagnostics
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Atomic and Subatomic Physics Research
- Cardiovascular Function and Risk Factors
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Disease and Adiposity
- Radiomics and Machine Learning in Medical Imaging
- Lanthanide and Transition Metal Complexes
- Coronary Interventions and Diagnostics
- Advanced Neuroimaging Techniques and Applications
- Advanced X-ray and CT Imaging
- Prostate Cancer Diagnosis and Treatment
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Pancreatic and Hepatic Oncology Research
- Extracellular vesicles in disease
- Ultrasound and Hyperthermia Applications
- Cell Adhesion Molecules Research
- Liver Disease Diagnosis and Treatment
- Electron Spin Resonance Studies
- Medical Image Segmentation Techniques
- Advanced NMR Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
University of California, Los Angeles
2016-2025
Cedars-Sinai Medical Center
2016-2025
Ijinkai Takeda General Hospital
2021-2025
The University of Texas Southwestern Medical Center
2025
Showa University
2024
La Jolla Bioengineering Institute
2016-2024
Cedars-Sinai Smidt Heart Institute
2014-2024
Anhui Special Equipment Inspection Institute
2024
Biomedical Research Institute
2024
Laboratoire d’Imagerie Biomédicale
2019-2022
Abstract The need for ECG gating presents many difficulties in cardiac magnetic resonance imaging (CMRI). Real‐time techniques eliminate the cine CMRI, but they cannot offer spatial and temporal resolution provided by segmented acquisition techniques. Previous MR signal‐based have demonstrated an ability to provide information; however, these result decreased efficiency. purpose of this work was develop a new “self‐gated” (SG) technique that eliminates efficiency deficits extracting motion...
<h3>SUMMARY:</h3> Identification of carotid artery atherosclerosis is conventionally based on measurements luminal stenosis and surface irregularities using in vivo imaging techniques including sonography, CT MR angiography, digital subtraction angiography. However, histopathologic studies demonstrate considerable differences between plaques with identical degrees indicate that certain plaque features are associated increased risk for ischemic events. The ability to look beyond the lumen...
Magnetic resonance image (MRI) in high spatial resolution provides detailed anatomical information and is often necessary for accurate quantitative analysis. However, typically comes at the expense of longer scan time, less coverage, lower signal to noise ratio (SNR). Single Image Super-Resolution (SISR), a technique aimed restore high-resolution (HR) details from one single low-resolution (LR) input image, has been improved dramatically by recent breakthroughs deep learning. In this paper,...
Background— Women with signs and symptoms of ischemia no obstructive coronary artery disease often have microvascular dysfunction (CMD), diagnosed by invasive reactivity testing (CRT). Although traditional noninvasive stress imaging is normal in CMD, cardiac MRI may be able to detect CMD this population. Methods Results— Vasodilator was performed 118 women suspected who had undergone CRT 21 asymptomatic reference subjects. Semi-quantitative evaluation the first-pass perfusion images...
Abstract The purpose of this work was to develop an ECG‐triggered, segmented 3D true‐FISP (fast imaging with steady‐state precession) technique improve the signal‐to‐noise ratio (SNR) and contrast‐to‐noise (CNR) breath‐hold coronary artery imaging. major task optimize appropriate magnetization preparation scheme permit saturation epicardial fat signal. An α/2 pulse used speed up approach following a frequency‐selective fat‐saturation in each heartbeat. application dummy cycles found reduce...
Segmented cine MRI generally requires breath-holding, which can be problematic for many patients. Navigator echo techniques, particularly successful free-breathing coronary MRA, are incompatible with the acquisition strategies and SSFP pulse sequences commonly used MRI. The purpose of this work is to introduce a new self-gating technique deriving respiratory gating information directly from raw imaging data acquired segmented uses interleaved radial k-space sampling provide low-resolution...
Purpose To develop a cardiac and respiratory self‐gated four‐dimensional (4D) coronary MRA technique for simultaneous anatomy function visualization. Methods A contrast‐enhanced, ungated spoiled gradient echo sequence with self‐gating (SG) 3DPR trajectory was used image acquisition. Data were retrospectively binned into different phases based on information extracted from SG projections using principal component analysis. Each phase reconstructed motion‐corrected self‐calibrating SENSE...
Magnetic resonance imaging (MRI) in the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction (CADUCEUS) trial revealed that cardiosphere-derived cells (CDCs) decrease scar size and increase viable myocardium after myocardial infarction (MI), but MRI has not been validated as an index of regeneration cell therapy. We tested validity contrast-enhanced quantifying scarred therapy a porcine model convalescent MI.
Interstitial tissue acidosis resulting from abnormal perfusion and metabolism is a hallmark of cancer. The current study demonstrates that chemical exchange saturation transfer (CEST) MRI can be used as noninvasive pH-weighted molecular imaging technique by targeting the between amine protons in extracellular bulk water. First, sensitivity CEST was validated phantoms under variety conditions, including different magnetic field strengths, amino acid concentrations, pH values. Amine compared...
Purpose To develop a three‐dimensional retrospective image‐based motion correction technique for whole‐heart coronary MRA with self‐navigation that eliminates both the need to setup diaphragm navigator and gate acquisition. Methods The proposed uses one‐dimensional track superior–inferior translation of heart, which acquired radial k‐space data is segmented into different respiratory bins. Respiratory then estimated in image space using an affine transform model subsequently this information...
Kawasaki disease (KD) is the most common cause of acquired cardiac in US children. In addition to coronary artery abnormalities and aneurysms, it can be associated with systemic arterial aneurysms. We evaluated development dilatation including abdominal aortic aneurysm (AAA) Lactobacillus casei cell-wall extract (LCWE)-induced KD vasculitis mouse model.We discovered that aortitis, arteritis myocarditis, LCWE-induced model also aorta AAA, as well renal iliac AAA induced mice was exclusively...
The purpose of this study was to develop a three-dimensional black blood imaging method for simultaneously evaluating the carotid and intracranial arterial vessel walls with high spatial resolution excellent suppression without contrast enhancement.The delay alternating nutation tailored excitation (DANTE) preparation module incorporated into variable flip angle turbo spin echo (SPACE) sequence improve signal suppression. Simulations phantom studies were performed quantify image variations...
Visual identification of coronary arterial lesion from three-dimensional computed tomography angiography (CTA) remains challenging. We aimed to develop a robust automated algorithm for computer detection artery lesions by machine learning techniques. A structured technique is proposed detect all with stenosis [Formula: see text]. Our consists two stages: (1) independent base decisions indicating the existence in each segment and (b) final decision made combining decisions. One support vector...
Purpose To develop a four‐dimensional MRI (4D‐MRI) technique to characterize the average respiratory tumor motion for abdominal radiotherapy planning. Methods A continuous spoiled gradient echo sequence was implemented with 3D radial trajectory and 1D self‐gating detection. Data were retrospectively sorted into different phases based on their temporal locations within cycle, each phase reconstructed by means of self‐calibrating CG‐SENSE program. Motion phantom, healthy volunteer patient...
Purpose Although three‐dimensional (3D) turbo spin echo (TSE) with variable flip angles has proven to be useful for intracranial vessel wall imaging, it is associated inadequate suppression of cerebrospinal fluid (CSF) signals and limited spatial coverage at 3 Tesla (T). This work aimed modify the sequence develop a protocol achieve whole‐brain, CSF‐attenuated T 1 ‐weighted imaging. Methods Nonselective excitation flip‐down radiofrequency pulse module were incorporated into commercial 3D TSE...
Cine cardiac magnetic resonance imaging (MRI) is widely used for the diagnosis of diseases thanks to its ability present cardiovascular features in excellent contrast. As compared computed tomography (CT), MRI, however, requires a long scan time, which inevitably induces motion artifacts and causes patients' discomfort. Thus, there has been strong clinical motivation develop techniques reduce both time artifacts. Given successful applications other medical tasks such as MRI super-resolution...
BACKGROUND: Early stage diagnosis of Pancreatic Ductal Adenocarcinoma (PDAC) is challenging due to the lack specific diagnostic biomarkers. However, stratifying individuals at high risk PDAC, followed by monitoring their health conditions on regular basis, has potential allow early stages. OBJECTIVE: To stratify for PDAC identifying predictive features in pre-diagnostic abdominal Computed Tomography (CT) scans. METHODS: A set CT features, potentially was identified analysis 4000 raw radiomic...
Background and aims: Pancreatic cancer (PC) incidence is increasing at a greater rate in young women compared to men. We performed race- ethnicity-specific evaluation of trends subgroups stratified by age sex investigate the association race ethnicity with these trends. Methods: Age-adjusted PC rates (IR) from years 2000 2018 were obtained SEER 21 database. Non-Hispanic White (White), Black (Black) Hispanic patients included. Age categories included older (ages ≥ 55) younger < adults....