A5102723192- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Tissue Engineering and Regenerative Medicine
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Cardiac Arrest and Resuscitation
- Heart Failure Treatment and Management
- Cardiac Fibrosis and Remodeling
- Congenital heart defects research
- Fuel Cells and Related Materials
- Cardiac pacing and defibrillation studies
- Asthma and respiratory diseases
- Mesenchymal stem cell research
- Electrospun Nanofibers in Biomedical Applications
- Cardiac electrophysiology and arrhythmias
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Extracellular vesicles in disease
- Mitochondrial Function and Pathology
- MRI in cancer diagnosis
- Advanced Neuroimaging Techniques and Applications
- Cardiac Imaging and Diagnostics
- Cardiac Valve Diseases and Treatments
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- IL-33, ST2, and ILC Pathways
University of Utah
2020-2025
Harrison Medical Center
2023-2025
Intermountain Medical Center
2023-2024
Lake City VA Medical Center
2024
Utah Department of Health
2022
Intermountain Healthcare
2022
LDS Hospital
2022
National and Kapodistrian University of Athens
2008-2021
University General Hospital Attikon
2021
Sotiria General Hospital
2018-2019
Ischemic injury in the heart induces an inflammatory cascade that both repairs damage and exacerbates scar tissue formation. Cardiosphere-derived cells (CDCs) are a stem-like population is derived ex vivo from cardiac biopsies; they confer cardioprotection regeneration acute myocardial infarction (MI). While regenerative effects of CDCs chronic settings have been studied extensively, little known about how cardioprotective process as cellular postconditioning. Here, we used rat model...
Background Multidisciplinary teams and regionalized care systems have been suggested to improve cardiogenic shock (CS) outcomes. We sought identify clinical factors associated with successful outcomes for patients developing CS at an outside healthcare facility (spoke) being transferred a quaternary medical center (hub). Methods Results Consecutive were evaluated (N=1162). Our study cohort comprised 412 spoke. primary end point was native heart survival (NHS) defined as discharge without...
Magnetic resonance imaging (MRI) in the CArdiosphere-Derived aUtologous stem CElls to reverse ventricUlar dySfunction (CADUCEUS) trial revealed that cardiosphere-derived cells (CDCs) decrease scar size and increase viable myocardium after myocardial infarction (MI), but MRI has not been validated as an index of regeneration cell therapy. We tested validity contrast-enhanced quantifying scarred therapy a porcine model convalescent MI.
The pathogenesis of HFpEF is unclear, but fibrosis, inflammation and hypertrophy have been put forth as likely contributors. CDCs are heart-derived cell products with anti-fibrotic anti-inflammatory properties.We questioned whether allogeneic rat might be able to decrease manifestations in hypertensive rats.Starting at 7 weeks age, Dahl salt-sensitive rats were fed a high-salt diet for 6-7 randomized receive intracoronary or placebo. normal chow served controls.High-salt developed...
Abstract Controversy surrounds the identity, origin, and physiologic role of endogenous cardiomyocyte progenitors in adult mammals. Using an inducible genetic labeling approach to identify small non‐myocyte cells expressing cardiac markers, we find that activated cardioblasts are rarely evident normal mouse heart. However, myocardial infarction results significant cardioblast activation at site injury. Genetically labeled isolated express transcription factors sarcomeric proteins, exhibit...
Cardiosphere-derived cells (CDCs) produce regenerative effects in the post-infarct setting. However, it is unclear whether CDCs are beneficial non-ischaemic dilated cardiomyopathy (DCM). We tested of CDC transplantation mice with cardiac-specific Gαq overexpression, which predictably develop progressive cardiac dilation and failure, accelerated mortality. Wild-type mouse (105 cells) or vehicle only were injected intramyocardially 6-, 8-, 11-week-old mice. Cardiac function deteriorated...
The clinical therapy for treating acute myocardial infarction is primary percutaneous coronary intervention (PPCI). PPCI effective at reperfusing the heart, however rapid re-introduction of blood can cause ischemia-reperfusion (I/R). Reperfusion injury responsible up to half final damage, but there are no pharmacological interventions reduce I/R. We previously demonstrated that inhibiting monocarboxylate transporter 4 (MCT4) and re-directing pyruvate towards oxidation blunt hypertrophy....
Despite the established role of late gadolinium enhancement (LGE) cardiovascular magnetic resonance (CMR) in characterizing chronic myocardial infarction (MI), a significant portion MI patients are contraindicative for use contrast agents. One promising alternative free technique is diffusion weighted CMR (dwCMR), which has been shown ex vivo to be sensitive fibrosis. We used recently developed dwCMR pigs compare apparent coefficient (ADC) maps with LGE imaging infarct characterization. In...
We sought to understand the cellular and tissue-level changes underlying attenuation of adverse remodeling by cardiosphere transplantation in acute myocardial infarction (MI).
Background Epicardial injection of heart-derived cell products is safe and effective post-myocardial infarction (MI), but clinically-translatable transendocardial has never been evaluated. We sought to assess the feasibility, safety efficacy percutaneous cells in porcine chronic ischemic cardiomyopathy. Methods Results studied a total 89 minipigs; 63 completed specified protocols. After NOGA-guided injection, we quantified engraftment escalating doses allogeneic cardiospheres or...
Extensive evidence from single-center studies indicates that a subset of patients with chronic advanced heart failure (HF) undergoing left ventricular assist device (LVAD) support show significantly improved function and reverse structural remodeling (ie, termed "responders"). Furthermore, we recently published multicenter prospective study, RESTAGE-HF (Remission Stage D Heart Failure), demonstrating LVAD combined standard HF medications induced remarkable cardiac functional improvement,...
Ischemic heart disease and acute myocardial infarction (AMI) is a leading cause of morbidity mortality. Improvements have been made in coronary interventions to restore blood flow, but ischemia/reperfusion (I/R) injury significantly impacts clinical outcomes. We previously reported that activation percutaneous mechanical unloading the left ventricle (LV) with transvalvular axial-flow device simultaneously reperfusion improves salvage. However, underlying mechanisms, potential adjuvant...
Infusion of allogeneic cardiosphere-derived cells (allo-CDCs) postreperfusion elicits cardioprotective cellular postconditioning in pigs with acute myocardial infarction. However, the long-term effects allo-CDCs have not been assessed. We performed a placebo-controlled pivotal study for evaluation, as well shorter-term mechanistic studies.Minipigs underwent 1.5-hour mid-left anterior descending balloon occlusion followed by reperfusion and were randomized to receive intracoronary or vehicle...
BACKGROUND: Cardiogenic shock (CS) can stem from multiple causes and portends poor prognosis. Prior studies have focused on acute myocardial infarction-CS; however, decompensated heart failure (ADHF)-CS accounts for most cases. We studied patients suffering ADHF-CS to identify clinical factors, early in their trajectory, associated with a higher probability of successful outcomes. METHODS: Consecutive CS were evaluated (N=1162). who developed at our hospital (N=562). Primary end point was...
Background— Preclinical studies in rodents and pigs indicate that the self-assembling microtissues known as cardiospheres may be more effective than dispersed cardiosphere-derived cells. However, desirable intracoronary route has been assumed to unsafe for cardiosphere delivery: Cardiospheres are large (30–150 μm), raising concerns about likely microembolization. We questioned these negative assumptions by evaluating safety efficacy of optimized delivery a porcine model convalescent...
The established clinical therapy for the treatment of acute myocardial infarction is primary percutaneous coronary intervention (PPCI) to restore blood flow ischemic myocardium. PPCI effective at reperfusing myocardium, however rapid re-introduction oxygenated also can cause ischemia-reperfusion (I/R) injury. Reperfusion injury culprit up half final damage, but there are no interventions reduce I/R We previously demonstrated that inhibiting lactate exporter, monocarboxylate transporter 4...
Background: Anxiety and depression are common psychological disturbances among asthmatic patients. The aim of the present study is assessment anxiety in patients their correlation with symptoms control level number exacerbations per year. Methods: One hundred asthma diagnosis, according to Global Initiative for Asthma (GINA), aged > 18 years old, having a stable disease, were included. Emotional status was evaluated using Hospital Depression Scale (HADS). Patients followed up year assess...
BACKGROUND: Multidisciplinary Shock Teams have improved clinical outcomes for cardiogenic shock, but their implementation costs not been studied. This study’s objective was to compare between patients treated with and without a Team determine if the team’s is cost-effective compared standard of care. METHODS: We examined refractory shock or at tertiary academic hospital from 2009 2018. Real-world data were used outcomes, including survival discharge, 1-year survival, quality-adjusted life...
New Findings What is the central question of this study? While load dependence diastolic function established for normal heart, little known about response acutely ischaemic and reperfused myocardium to alterations in afterload. main finding its importance? Using a model that simulates clinical scenario acute ischaemia–reperfusion, we show increased afterload aggravates dysfunction during both ischaemia reperfusion. In addition, induces dyssynchrony, which might be underlying mechanism...