A5029339474- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Pleural and Pulmonary Diseases
- Pediatric health and respiratory diseases
- Congenital Diaphragmatic Hernia Studies
- Inhalation and Respiratory Drug Delivery
- TGF-β signaling in diseases
- Trauma Management and Diagnosis
- Lung Cancer Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Cardiac, Anesthesia and Surgical Outcomes
- Sarcoidosis and Beryllium Toxicity Research
- Bone and Dental Protein Studies
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Perfectionism, Procrastination, Anxiety Studies
- Pulmonary Hypertension Research and Treatments
- Sirtuins and Resveratrol in Medicine
- Electrolyte and hormonal disorders
Medical University of Vienna
2022-2024
Vienna General Hospital
2023-2024
University General Hospital Attikon
2012-2022
Sotiria General Hospital
2015-2022
National and Kapodistrian University of Athens
2012-2021
University of Ioannina
2021
Chest Diseases Hospital
2016
Athens State University
2015
401 General Military Hospital of Athens
2014
Clara cell secretory protein (CC16) is associated with Th2 modulation. Surfactant D (SPD) plays an important role in surfactant homeostasis and eosinophil chemotaxis. We measured CC16 SPD sputum supernatants of 84 asthmatic patients 12 healthy controls. In 22 asthmatics, we additionally levels BAL assessed smooth muscle area (SMA), reticular basement membrane (RBM) thickness, epithelial detachment (ED) bronchial biopsies. Induced were significantly higher severe asthma (SRA) compared to...
The programmed cell death-ligand 1 (PD-L1) protein expression on tumor cells predicts the efficacy of immunotherapy in patients with non-small lung cancer. However, assessment PD-L1 has limited power for selecting due to intra-tumoral heterogeneity and inter-tumoral expression, inter-observer variability scoring staining, reproducibility. These difficulties pitfalls interpreting are discussed detail this review.
Asthma control refers to the extent which manifestations of asthma have been reduced or eradicated by treatment. Interleukin-13 (IL-13) has a central role in Th2 response and serves as possible therapeutic target uncontrolled asthma. Fraction exhaled nitric oxide (FeNO) sputum eosinophils modest performance evaluation control.To assess diagnostic IL-13 for furthermore investigate FeNO.One hundred seventy patients with were studied. All subjects underwent assessment test (ACT), lung function...
Sputum and blood eosinophils are proposed as candidate biomarkers for the identification of chronic obstructive pulmonary disease (COPD) patients at risk exacerbation treatment response. In this study, we evaluated associations with presence emphysema in COPD patients. Induced sputum eosinophil measurements were performed consecutive Patients underwent lung function testing high resolution computed tomography (HRCT) chest was quantified. emphysematous lesions ≥15% parenchyma considered...
Background: Anxiety and depression are common psychological disturbances among asthmatic patients. The aim of the present study is assessment anxiety in patients their correlation with symptoms control level number exacerbations per year. Methods: One hundred asthma diagnosis, according to Global Initiative for Asthma (GINA), aged > 18 years old, having a stable disease, were included. Emotional status was evaluated using Hospital Depression Scale (HADS). Patients followed up year assess...
Although modern treatment of asthma improves control, some patients still experience exacerbations. The aim the present study was to detect predictors asthmatic exacerbations Methods: We included with followed up in clinics 2 tertiary University hospitals. Demographic and functional characteristics, levels exhaled NO, inflammatory biomarkers (IL-13, ΕCP και IL-8) cell counts induced sputum were recorded at baseline. Measurements performed stability considered as their personal best. Patients...
Introduction Female hormones and obesity have an impact on women with asthma. We aimed to describe how these components affect asthma inflammatory processes.
Remission of asthma can occur as part the natural history disease; however, use biologics result in disease remission some patients.
Background: Sestrin 2, Endocan, and Sirtuin 1 are distinct molecules with some biologic actions associated asthma pathophysiology. The aim of the present study was to determine molecular level differences attributable underlying severity. Methods: We initially recruited 85 asthmatics a wide spectrum All patients were optimally treated according current guidelines. Demographics, test results lung function, treatment regimes all recorded. measured in different biological samples (sputum two...
Smoking is associated with worse asthma outcomes and may modify airway inflammation. Such modification be mediated through an effect on prostaglandin E(2) (PGE(2)) cysteinyl leukotrienes (Cyst-LTs).We aimed to determine the levels of both PGE(2) Cyst-LTs in sputum supernatants patients investigate smoking habit as well their associations inflammatory cells, bronchial hyperresponsiveness (BHR) lung function.Ninety-eight (47 smokers) 40 healthy subjects (20 were studied. All underwent...
ABSTRACT Background and objective Activin A is a pleiotropic cytokine holding fundamental role in inflammation tissue remodelling. Follistatin can modulate the bioactivity of activin. We aimed to measure activin follistatin sputum supernatants bronchoalveolar lavage ( BAL ) asthmatic patients determine possible associations with severity as well inflammatory remodelling indices. Methods total 58 (33 severe refractory asthma SRA )) 10 healthy controls underwent induction for % cells, A,...