A5039311118- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- COVID-19 Clinical Research Studies
- IL-33, ST2, and ILC Pathways
- Pediatric health and respiratory diseases
- Inhalation and Respiratory Drug Delivery
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Obstructive Sleep Apnea Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Bone and Dental Protein Studies
- Lung Cancer Diagnosis and Treatment
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Cystic Fibrosis Research Advances
- Lymphatic System and Diseases
- Sepsis Diagnosis and Treatment
- Digestive system and related health
- Angiogenesis and VEGF in Cancer
Sotiria General Hospital
2016-2025
National and Kapodistrian University of Athens
2016-2025
Hoag Memorial Hospital Presbyterian
2024
Oikos University
2024
Oikon (Croatia)
2024
G. Papanikolaou General Hospital
2023
Aristotle University of Thessaloniki
2023
Centre of Excellence for Health, Immunity and Infections
2023
University of Copenhagen
2023
Rigshospitalet
2023
Abstract Early increase of soluble urokinase plasminogen activator receptor (suPAR) serum levels is indicative increased risk progression coronavirus disease 2019 (COVID-19) to respiratory failure. The SAVE-MORE double-blind, randomized controlled trial evaluated the efficacy and safety anakinra, an IL-1α/β inhibitor, in 594 patients with COVID-19 at progressing failure as identified by plasma suPAR ≥6 ng ml −1 , 85.9% ( n = 510) whom were receiving dexamethasone. At day 28, adjusted...
According to induced sputum cell count, four different asthma phenotypes have been recognized (eosinophilic, neutrophilic, mixed and paucigranulocytic). The aim of this study was detect functional inflammatory characteristics patients with paucigranulocytic asthma.A total 240 asthmatic were categorized into the according counts in sputum. All underwent pulmonary function tests, measurement fraction exhaled nitric oxide (FeNO). levels IL-8, IL-13 eosinophilic cationic protein (ECP) also...
Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking.Programmed cell death-1 (PD-1)/ programmed death ligand-1 (PD-L1) expression mediastinal nodes and lung tissues was analyzed. PD-1, PD-L1 mRNA measured tracheobronchial of mice following bleomycin-induced injury on day 14. Finally, the effect PD-1 inhibitor, pembrolizumab, investigated.We...
Abstract Background Endotype classification may guide immunomodulatory management of patients with bacterial and viral sepsis. We aimed to identify immune endotypes transitions associated response anakinra (human interleukin 1 receptor antagonist) in participants the SAVE-MORE trial. Methods Adult hospitalized radiological findings PCR-confirmed severe pneumonia caused by SARS-CoV-2 plasma-soluble urokinase plasminogen activator levels ≥ 6 ng/ml trial (NCT04680949) were characterized at...
Abstract Background Recent studies have provided evidence for a link between leptin and tumor necrosis factor-alpha (TNF-α). Insulin-like growth factor I (IGF-I) mediates the metabolic effects of hormone (GH). The GH axis is believed to be suppressed in chronic obstructive pulmonary disease (COPD). aim this study find out whether acute exacerbations COPD are followed by changes plasma insulin-like levels furthermore, these related systemic inflammation. Methods We measured serum leptin,...
Background: Previous preclinical data have shown that the dynamic cross-talk between abnormal tumor vasculature and immune cell factors in microenvironment may exert a critical role progression treatment resistance of non-small lung cancer (NSCLC). In clinical setting, variety blood-based angiogenesis- immune-related are being increasingly investigated as potential biomarkers prognosis or response immunotherapy-treated NSCLC. We herein aimed to evaluate relevance peripheral blood levels...
Data on type 2 (T2)-low severe asthma (SA) frequency is scarce, resulting in an undefined unmet therapeutic need this patient population. Our objective was to assess the and characterize profile burden of T2-low SA Greece. PHOLLOW a cross-sectional study adult patients. Based novel proposed classification system, patients were classified as if blood eosinophil count (BEC; cells/μL) <150, fractional exhaled nitric oxide (FeNO) < 25 ppb any allergy status or BEC 150/FeNO 50 ppb/no 300/FeNO...
The availability of antigen tests for SARS-CoV-2 represents a major step the mass surveillance incidence infection, especially regarding COVID-19 asymptomatic and/or early-stage patients. Recently, we reported development Bioelectric Recognition Assay-based biosensor able to detect S1 spike protein expressed on surface virus in just three minutes, with high sensitivity and selectivity. working principle was established by measuring change electric potential membrane-engineered mammalian...
<b>Purpose:</b> We investigated the efficacy of Mepolizumab treatment by assessing airway remodeling outcomes and patient characteristics associated with response. <b>Methods:</b> MESILICO is a multicenter study. Patients late-onset severe eosinophilic asthma fixed obstruction were eligible to be administered Mepolizumab. Forty-seven patients recruited. Bronchial biopsies obtained before initiation after 12 months treatment. Airway was assessed via changes from baseline in endobronchial...