A5037442955- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Lung Cancer Research Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Inhalation and Respiratory Drug Delivery
- Respiratory and Cough-Related Research
- Immunotherapy and Immune Responses
- Sarcoidosis and Beryllium Toxicity Research
- Neuroendocrine Tumor Research Advances
- Pediatric health and respiratory diseases
- Colorectal Cancer Treatments and Studies
- IL-33, ST2, and ILC Pathways
- Lung Cancer Diagnosis and Treatment
- Inflammatory mediators and NSAID effects
- RNA Interference and Gene Delivery
- Allergic Rhinitis and Sensitization
- Synthesis and biological activity
- Cancer-related molecular mechanisms research
- Neuroblastoma Research and Treatments
- Sinusitis and nasal conditions
- Intraperitoneal and Appendiceal Malignancies
- MicroRNA in disease regulation
- Extracellular vesicles in disease
Aristotle University of Thessaloniki
2016-2025
G. Papanikolaou General Hospital
2015-2025
Telio (Norway)
2024
The emergence of novel antiprogrammed cell death protein-1 (PD-1) inhibitors in non-small lung cancers (NSCLC) has revolutionized the therapeutic landscape this disease. Although overall survival (OS) improved first- and second-line therapy settings for advanced NSCLC, benefit is not universal. In a climate global scrutiny healthcare costs potential toxicities related to immunotherapy, appropriate patient selection crucial. aim study was evaluate prognostic predictive biomarkers...
Abstract Background Idiopathic Pulmonary Fibrosis (IPF) represents a chronic lung disease with unpredictable course. Methods We aimed to investigate prognostic performance of complete blood count parameters in IPF. Treatment-naïve patients IPF were retrospectively enrolled from two independent cohorts (derivation and validation) split into subgroups (high low) based on median baseline monocyte red cell distribution width (RDW). Results Overall, 489 cohort: 300, validation 189) analyzed. In...
ABSTRACT Background and objective The acute effects of e‐cigarettes have not been scientifically demonstrated yet. aim this study was to assess the changes in pulmonary function airway inflammation patients with asthma after vaping one e‐cigarette. Methods Twenty‐five smokers suffering from stable moderate according GINA guidelines no other comorbidities 25 healthy matched baseline characteristics asthmatic were recruited. PFT, IOS, FeNO EBC performed before e‐cigarette nicotine. pH...
Immunosuppressive chemoresistance is a major challenge in lung cancer treatment. Exosomes present the tumor microenviroment are implicated chemoresistant-related immune suppression, and metastasis but exact pathogenic role of lung-derived exosomes still uncertain. Recent reports reveal that pathogenesis strictly associated with exosomal supportive status dysfunctional system. In this study, we investigate Kras-derived chemoresistant immunosuppression which neoplastic cells create...
<b>Purpose:</b> We investigated the efficacy of Mepolizumab treatment by assessing airway remodeling outcomes and patient characteristics associated with response. <b>Methods:</b> MESILICO is a multicenter study. Patients late-onset severe eosinophilic asthma fixed obstruction were eligible to be administered Mepolizumab. Forty-seven patients recruited. Bronchial biopsies obtained before initiation after 12 months treatment. Airway was assessed via changes from baseline in endobronchial...
Lung cancer is still the leading cause of death in United States and worldwide (1). The 5-year survival rate only 14% implying need for new treatments (2). According to National Cancer Institute Office Genomics, facilitation personalized medicine (PCM), based on genetic aberrations which exist human malignancies, three goals have been established; first, enhancement understanding molecular mechanisms cancer; second, acceleration genomic science technology development; third, translation data...
Background: The aim of this present study was to determine serum biomarker levels and their correlation with respiratory function the clinical course patients idiopathic pulmonary fibrosis (IPF). Materials Methods: This included 72 IPF patients, according ATS/ERS criteria, in whom antifibrotic treatment initiated. Blood samples were taken, biomarkers, such as KL-6, SP-D, CCL18, CXCL13, VEGF-A, IL-8, IGFBP-1, IGFBP-2, IGFBP-7 ICAM-1 measured using ELISA methodology. Pulmonary tests (FVC, TLC,...
Lung cancer is a leading cause of cancer-related deaths globally, includes small cell lung (SCLC), characterized by its aggressive nature and advanced disease at diagnosis. However, the identification reliable biomarkers for SCLC has proven challenging, as no consistent predictive biomarker been established. Nonetheless, certain tumor-associated antigens, including programmed death-ligand 1 (PDL1) Delta-Like Ligand 3 (DLL3), show promise targeted antibody-based immunotherapy. To ensure...
Background: Factors that could predict which patients will benefit from Immune Checkpoint Inhibitors (ICIs) are not fully understood. This study aimed to investigate the prognostic value of KRAS biomarker in with advanced non-small cell lung cancer (NSCLC) relation clinical characteristics, treatment response and PDL1 expression. Patients methods: The included 100 NSCLC who received immunotherapy or without chemotherapy as 1st line treatment. In biopsy samples, expression rate somatic...
Background: Factors that could predict which patients will benefit from Immune Checkpoint Inhibitors (ICIs) are not fully understood. This study aimed to investigate the prognostic value of KRAS biomarker in with advanced non-small cell lung cancer (NSCLC) relation clinical characteristics, treatment response and PDL1 expression. Patients methods: The included 100 NSCLC who received immunotherapy or without chemotherapy as 1st line treatment. In biopsy samples, expression rate somatic...
ABSTRACT Carbon quantum dots (CQDs) represent a rapidly emerging class of nanomaterials with significant potential in biomedical applications due to their tunable fluorescence, high biocompatibility, and versatile functionalization. This review focuses on the recent progress utilizing CQDs for drug delivery, bioimaging, biosensing, cancer therapy. With unique optical properties, such as yield, photostability, enable precise bioimaging sensitive biosensing. Their small size, ease surface...
Purpose: Somatostatin is a peptide with potent and broad antisecretory action, which makes it an invaluable drug target for the pharmacological management of pituitary adenomas neuroendocrine tumors.Furthermore, somatostatin (SST) receptors (SSTR1, 2A B, 3, 4 5) belong to G protein coupled receptor family are overexpressed in tumors.Since, human small-cell lung cancer overexpresses (STTR), they could be legitimate targets treating SCLC.The aim this study was evaluation cytotoxicity...