A5002901869- Tissue Engineering and Regenerative Medicine
- Asthma and respiratory diseases
- Cardiac Fibrosis and Remodeling
- Mesenchymal stem cell research
- Cardiac Ischemia and Reperfusion
- Extracellular vesicles in disease
- IL-33, ST2, and ILC Pathways
- Mechanical Circulatory Support Devices
- Pluripotent Stem Cells Research
- Respiratory and Cough-Related Research
- Congenital heart defects research
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Pulmonary Hypertension Research and Treatments
- Lymphatic System and Diseases
- Cardiac and Coronary Surgery Techniques
- Vitamin D Research Studies
- Cardiovascular Disease and Adiposity
- Anesthesia and Neurotoxicity Research
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Angiogenesis and VEGF in Cancer
- Iron Metabolism and Disorders
- Coronary Interventions and Diagnostics
University of Utah
2024
Cedars-Sinai Medical Center
2012-2018
Cedars-Sinai Smidt Heart Institute
2014-2018
National and Kapodistrian University of Athens
2008-2017
Alexandra Hospital
2011-2016
Sotiria General Hospital
2011-2015
Keio University
2015
Capricor Therapeutics (United States)
2015
North Carolina State University
2015
University of North Carolina at Chapel Hill
2015
Naturally secreted nanovesicles known as exosomes are required for the regenerative effects of cardiosphere-derived cells (CDCs), and mimic benefits CDCs in rodents. Nevertheless, have not been studied a translationally realistic large-animal model. We sought to optimize delivery assess efficacy CDC-secreted pig models acute (AMI) convalescent myocardial infarction (CMI). In AMI, pigs received human CDC (or vehicle) by intracoronary (IC) or open-chest intramyocardial (IM) 30 min after...
Intracoronary delivery of cardiosphere-derived cells (CDCs) has been demonstrated to be safe and effective in porcine human chronic myocardial infarction. However, intracoronary CDCs after reperfusion acute infarction never assessed a clinically-relevant large animal model. We tested as adjunctive therapy model infarction.First, escalating doses (5, 7.5, 10 million cells) allogeneic were administered 30 minutes reperfusion. Forty-eight hours later, left ventriculography was performed animals...
<h3>BACKGROUND:</h3> Pulmonary microcirculation abnormalities are the main determinants of pulmonary arterial hypertension (PAH) pathophysiology. We hypothesized that PAH patients have peripheral tissue alterations might benefit from hyperoxic breathing. evaluated muscle with near-infrared spectroscopy, before and after <h3>METHODS:</h3> Eight subjects, 8 healthy subjects (controls) matched for age, sex, body mass index, 16 chronic heart failure functional capacity underwent spectroscopy....
In Brief PURPOSE: The loss of lean muscle mass and strength is a common problem in chronic heart failure (CHF) patients. Endurance training efficient improving patient exercise capacity. This study sought to evaluate the additional effects on body composition chf patients participating an interval program. METHODS: Twenty consecutive, stable CHF participated rehabilitation Subjects were randomly assigned aerobic (n = 10) or combined plus group 10). Aerobic performed cycle ergometers....
Osteopontin (OPN) is a glycoprotein that has been associated with inflammation and fibrosis. Severe refractory asthma (SRA) characterised by an intense inflammatory remodelling process. The aim of this study was to investigate the levels OPN in sputum supernatants patients SRA, compare them milder forms disease their possible association mediators cells involved process.33 29 moderate asthma, 21 steroid-naïve 20 healthy subjects were studied. All underwent lung function tests, bronchial...
Chronotropic response to exercise and heart rate recovery immediately after (HRR(1) ) are valid prognostic markers in patients with chronic failure (CHF). The aim of this study was evaluate profile during CHF early left ventricular assist device (LVAD) implantation.We enrolled seven stable consecutive (five males, mean age: 45 ± 16 years) 1 month LVAD (HeartMate II; Thoratec Corp, Pleasanton, CA, USA) implantation, healthy subjects, 14 advanced HF (HF control group) who performed an...
ABSTRACT Newts can regenerate amputated limbs and cardiac tissue, unlike mammals which lack broad regenerative capacity. Several signaling pathways involved in cell proliferation, differentiation survival during newt tissue regeneration have been elucidated, however the factors that coordinate between cells, as well conservation of these other animals, are not defined. Here we report media conditioned by limb explant cells (A1 cells) protect mammalian cardiomyocytes from oxidative...
Abstract Background: Airway and vascular remodeling may play a prominent role in the clinical severity of severe refractory asthma ( SRA ). Angiopoietin‐1 A ng‐1) is an essential mediator angiogenesis by establishing integrity, whereas angiopoietin‐2 ng‐2) acts as its natural inhibitor. Objective: We aimed to determine levels angiopoietins sputum supernatants patients with investigate possible associations mediators cells involved both inflammatory processes. Methods: Thirty‐eight , 35...
Single-vessel, intracoronary infusion of stem cells under stop-flow conditions has proven safe but achieves only limited myocardial coverage. Continuous flow delivery to one or more coronary vessels may achieve broader coverage for treating cardiomyopathy, not been investigated. Using nonocclusive guiding catheters, we infused allogeneic cardiosphere-derived (CDCs) either in a single vessel sequentially all three arteries porcine ischemic cardiomyopathy and used magnetic resonance imaging...
Angiopoietin-1 (Ang-1) is an essential mediator of angiogenesis by establishing vascular integrity, whereas angiopoietin-2 (Ang-2) acts as its natural inhibitor.We aimed to determine the levels angiopoietins in sputum supernatants patients with optimally treated asthma and investigate whether smoking represents a significant covariate on above possible processes.Eighty-seven (42 smokers) 28 healthy subjects (14 were studied. All underwent lung function tests, bronchial hyper-responsiveness...
AIM:To evaluate Quality of life (QoL) in chronic heart failure (CHF) relation to Neuroticism personality trait and CHF severity. METHODS:Thirty six consecutive, outpatients with Chronic Heart Failure (6 females 30 males, mean age: 54 ± 12 years), a left ventricular ejection fraction ≤ 45% at optimal medical treatment the time inclusion, were asked answer Kansas City Cardiomyopathy Questionnaire (KCCQ) for
Introduction: Cardiac fibrosis is one of the major hallmarks heart failure (HF) progression. Fibrosis initiated as a repair mechanism following any kind cardiac injury including attack, inflammation, hypertension, etc. Briefly, fibroblasts are activated to form myofibroblasts that secrete collagen. Persistent fibroblast activation leads excess collagen deposition leading tissue stiffening and impaired contractility thereby HF. To date, there no anti-fibrotic therapy used in HF patients....