A5074141959- Chronic Obstructive Pulmonary Disease (COPD) Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Respiratory Support and Mechanisms
- Airway Management and Intubation Techniques
- Smoking Behavior and Cessation
- Long-Term Effects of COVID-19
- Inflammatory Biomarkers in Disease Prognosis
- Lung Cancer Treatments and Mutations
- Radiomics and Machine Learning in Medical Imaging
- Inhalation and Respiratory Drug Delivery
- Vascular Anomalies and Treatments
- Obstructive Sleep Apnea Research
- HIV Research and Treatment
- Chromatin Remodeling and Cancer
- Air Quality and Health Impacts
- Occupational and environmental lung diseases
- Eosinophilic Disorders and Syndromes
- Systemic Sclerosis and Related Diseases
- Peptidase Inhibition and Analysis
- Noise Effects and Management
- Lung Cancer Research Studies
- Mechanisms of cancer metastasis
National and Kapodistrian University of Athens
2013-2025
Sotiria General Hospital
2013-2025
University Hospital of Zurich
2021
Hellenic Cancer Society
2010-2013
The genes coding for the tumor suppressors p53 and retinoblastoma (Rb) are inactivated in vast majority of small cell lung cancer (SCLC) tumors. Data support notion that these two deleterious genetic events represent initial steps development SCLC, making them essential a epithelial to progress toward acquisition malignant phenotype. With loss TP53 RB1, their broad suppressive functions eliminated normal is able proliferate indefinitely, escape entering into cellular senescence, evade death,...
Mediastinal lymph node enlargement is prevalent in patients with idiopathic pulmonary fibrosis (IPF). Studies investigating whether this phenomenon reflects specific immunologic activation are lacking.Programmed cell death-1 (PD-1)/ programmed death ligand-1 (PD-L1) expression mediastinal nodes and lung tissues was analyzed. PD-1, PD-L1 mRNA measured tracheobronchial of mice following bleomycin-induced injury on day 14. Finally, the effect PD-1 inhibitor, pembrolizumab, investigated.We...
SWItch/sucrose non-fermentable (SWI/SNF) is a large protein complex with central role in chromatin remodeling and genome transcription. The catalytic subunits of the SWI/SNF related BAF subunit ATPase 2 (SWI/SNF SMARCA2; also called BRM) 4 (SMARCA4; BRG1) are encoded by SMARCA2 SMARCA4 genes, respectively, mutually exclusive. Loss either and/or has been previously reported several types malignant solid tumors gastrointestinal genitourinary tract. So far, their absence non-small cell lung...
During the current pandemic, we witnessed a rise of post-intubation tracheal stenosis (PITS) in patients intubated due to COVID-19. We prospectively analyzed data from referred our institution during last 18 months for severe symptomatic upper airway complications. Interdisciplinary bronchoscopic and/or surgical management was offered. Twenty-three with PITS tracheoesophageal fistulae were included. They had undergone 31.85 (±22.7) days ICU hospitalization and 17.35 (±7.4) intubation....
Pirfenidone is an antifibrotic compound able to slow down disease progression in patients with idiopathic pulmonary fibrosis (IPF).To investigate the safety and efficacy of pirfenidone IPF a real-life setting.This was multicenter, retrospective, real-life, observational study for receiving pirfenidone.We identified 92 pirfenidone. Eighty (70 males 10 females, mean age ± SD: 68.1 + 7.5, %FVC SD = 74.9 17.2, %DLCO 48.1 16.9) were included analysis. Skin-related (25%) gastrointestinal (17.5%)...
Introduction Successful smoke-free legislation is dependent on political will, enforcement and societal support. We report the success pitfalls of a non-enforced nationwide in Greece, as well ways which compliance enforcement-related factors, including ashtrays signage, may impact indoor secondhand smoke (SHS) concentrations. Methods A follow-up study venues (n = 150, at baseline, n 75 2-year follow-up) Greece assessed particulate matter with diameter less than 2.5 micrometers (PM2.5)...
Background & AimsHepatitis B virus (HBV) coinfection is common among people living with HIV (PLWH) and the most important cause of hepatocellular carcinoma (HCC). Whereas risk prediction tools for HCC exist patients HBV monoinfection, they have not been evaluated in PLWH. We performed an external validation PAGE-B HIV/HBV coinfection.MethodsWe included PLWH a positive HBsAg without before starting tenofovir from four European cohorts, estimated predictive performance on occurrence over 15...
A1Antitrypsin deficiency (AATD) pathogenic mutations are expanding beyond the PI*Z and PI*S to a multitude of rare variants. investigate genotype clinical profile Greeks with AATD. Symptomatic adult-patients early-emphysema defined by fixed airway obstruction computerized-tomography scan lower than normal serum AAT levels were enrolled from reference centers all over Greece. Samples analyzed in Laboratory, University Marburg-Germany. Included 45 adults, 38 homozygous or compound heterozygous...
Introduction: Smoking is known to have a long-term impact on lung function; however, the acute physiological response of smoking single cigarette and influential role pack years cigarettes per day pulmonary indices remains an area interest, especially among young smokers. Methods: 50 naive smokers (ages: 18–26, 24 males: mean 3.8) participated in this experimental study. Respiratory resistance (R), reactance (X ), impedance (Z ) were assessed through impulse oscillometry. The participants'...
While combination therapy completely suppresses HIV-1 replication in blood, functional virus persists CD4+ T cell subsets non-peripheral compartments that are not easily accessible. To fill this gap, we investigated tissue-homing properties of cells transiently appear the circulating blood. Through separation and vitro stimulation, "Gag Envelope reactivation co-detection assay" (GERDA) enables sensitive detection Gag+/Env+ protein-expressing down to about one per million using flow...
Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving sampling location and yield. Previous studies have defined validated nCLE criteria for malignancy, airway parenchyma. Larger demonstrating effect are lacking. We aim investigate if nCLE-imaging...
Background/Objectives: Cardiorespiratory complications are commonly reported among patients with long COVID-19 syndrome. However, their effects on exercise capacity remain inconclusive. We investigated the impact of tolerance combining cardiopulmonary testing (CPET) resting echocardiographic data. Methods: Forty-two (55 ± 13 years), 149 92 days post-hospital discharge, and ten healthy age-matched participants underwent echocardiography an incremental CPET to limit tolerance. Left ventricular...
Our aim was to assess second-hand smoke (SHS) exposure in hospitality venues after the smoke-free legislation implemented September 2010 Greece and compare with when a partial ban place 2006 no place.Hospitality were prospectively assessed for their indoor concentrations of particulate matter (PM(2.5)) during phase (n=149) complete (n=120, 80% followed up), while overall matched by venue comparisons also performed (no vs. ban). Comparisons previously collected data performed.Indoor air...
Background Endoluminal therapy either by dilatation, scar tissue resection or stent insertion is an established treatment for non-malignant airway stenosis although the surgical approach still considered "gold standard." No clear consensus exists on structured role of each modality. Aims We aimed to investigate bronchoscopic management in non-operable tracheal cases, evaluating effectiveness and safety procedure based a algorithmic approach. Patients methods This prospective study was...
1. Exposure to secondhand smoke (SHS) can occur in many places; however, regulations banning smoking may reduce the sources of exposure SHS personal areas such as family car, a source brief but potently intense exposure. 2. Fifteen non-smoking volunteers were exposed sidestream concentrations 5000 µg/m(3), within simulated car setting. The Fraction Exhaled Nitric Oxide (FeNO) was calculated, dynamic flow volumes assessed through spirometry; while airway impedance (Z), resistance (R), and...
Stewart's approach is known to have better diagnostic accuracy for the identification of metabolic acid-base disturbances compared traditional methods based either on plasma bicarbonate concentration ([HCO3-]) and anion gap (AG) or base excess/deficit (BE). This study aimed identify disorders using approaches in critically ill COVID-19 patients admitted ICU, recognize potential hidden abnormalities assess prognostic value these patient outcome. was a single-center retrospective study, which...
Abstract Transbronchial lung cryobiopsy (TBLC) is a relatively new technique for obtaining biopsies, known being the least invasive method while offering high diagnostic yield, favourable safety profile, and significant reduction in morbidity, mortality, hospital stay length compared to surgical biopsy. Radial‐EBUS (r‐EBUS) represent cornerstone modality accessing ‘invisible’ peripheral pulmonary lesions. However, major drawback of these techniques lack ‘real‐time’ visualization biopsy...
Asthma is a common chronic inflammatory disease of the airways that affects more than 330 million people globally. Severe asthma, despite being 5–10% total asthmatic population presents significant morbidity and high cost due to health care utilization. The management severe asthma has dramatically changed with use biologics. However, biologics have been approved only for patients type-2 mediated inflammation. Eosinophils are central in T2 process this stands true form as well. In review, we...
Reticulation, ground glass opacities and post-infection bronchiectasis are present three months following hospitalisation in patients recovering from SARS-CoV-2 infection associated with the severity of acute infection. However, scarce data exist on small airways impairment lung hyperinflation long COVID-19.