A5046929492- Cystic Fibrosis Research Advances
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Neonatal Respiratory Health Research
- Respiratory viral infections research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- COVID-19 and Mental Health
- Immune cells in cancer
- Asthma and respiratory diseases
- Pediatric health and respiratory diseases
- Venous Thromboembolism Diagnosis and Management
- Immune Response and Inflammation
- COVID-19 epidemiological studies
- Pulmonary Hypertension Research and Treatments
- Antibiotic Resistance in Bacteria
- Respiratory Support and Mechanisms
- Inhalation and Respiratory Drug Delivery
- Non-Invasive Vital Sign Monitoring
- COVID-19 Clinical Research Studies
- Inflammation biomarkers and pathways
- Eosinophilic Disorders and Syndromes
- Alcoholism and Thiamine Deficiency
- Vitamin C and Antioxidants Research
- Cell Adhesion Molecules Research
- Renal Diseases and Glomerulopathies
- Genomics and Rare Diseases
University of Crete
2022-2025
University of Cyprus
2019-2025
Sotiria General Hospital
2023-2025
University Hospital of Heraklion
2024
Crete University Press
2024
Cyprus Institute of Neurology and Genetics
2023
ORCID
2021
SWItch/sucrose non-fermentable (SWI/SNF) is a large protein complex with central role in chromatin remodeling and genome transcription. The catalytic subunits of the SWI/SNF related BAF subunit ATPase 2 (SWI/SNF SMARCA2; also called BRM) 4 (SMARCA4; BRG1) are encoded by SMARCA2 SMARCA4 genes, respectively, mutually exclusive. Loss either and/or has been previously reported several types malignant solid tumors gastrointestinal genitourinary tract. So far, their absence non-small cell lung...
The Translational Science Working Group at the European Respiratory Society (ERS) aims to bridge gap between basic and clinical science by providing a platform where scientists, clinicians experts in respiratory field can actively shape translational research. For 2023 Congress, dedicated sessions were created of interest many assemblies from scientific point view tagged as sessions, attracting same room discuss relevant topics strengthening efforts among all ERS assemblies.
Abstract Between March and April 2020, Cyprus Greece health authorities enforced three escalated levels of public interventions to control the COVID-19 pandemic. We quantified compliance 108 asthmatic schoolchildren (53 from Cyprus, 55 Greece, mean age 9.7 years) both countries intervention levels, using wearable sensors continuously track personal location physical activity. Changes in ‘fraction time spent at home’ ‘total steps/day’ were assessed with a mixed-effects model adjusting for...
We aimed to determine a genetic diagnosis in the national primary ciliary dyskinesia (PCD) cohort of Cyprus, an island with high disease prevalence. used targeted next-generation sequencing (NGS) 39 PCD genes 48 patients Greek-Cypriot and other ancestries. achieved molecular 74% unrelated families tested. identified 24 different mutations 11 genes, 12 which are novel. Homozygosity was more common than non-Greek-Cypriot (88% vs. 46.2%, p = .016). Four (DNAH11:c.5095-2A>G,...
Abstract Objectives To prospectively quantify at the community level changes in asthma symptom control and other morbidity indices, among asthmatic schoolchildren response to coronavirus disease 2019 (COVID‐19) lockdown measures. Methods In Spring 2020, we assessed monthly pediatric test (c‐ACT), medication usage, infections unscheduled visits for with active Cyprus Greece. We compared indices before during measures, while participants’ time spent home was objectively by wearable sensors....
Abstract Background Specialized clinical care for cystic fibrosis (CF) in Cyprus, a small island country, has been implemented since the 1990s. However, only recently, national CF patient registry established systematic recording of patients’ data. In this study, we aim to present data on epidemiological, genotypic and phenotypic features patients country from most recent collection 2019, with particular emphasis notable rare or unique cases. Results Overall, 52 are presented, 5 whom have...
Coronavirus disease 2019 (COVID-19) pneumonia is associated with extensive pulmonary microangiopathy and the enlargement of artery (PA), while its progression after remission has not been investigated yet. The aim was to assess diametral increase in PA COVID-19 pneumonia, as revealed on chest computed tomography (CT), further investigate progression. This a retrospective cohort study patients without prior history hypertension, who underwent CT angiography before, during, infection....
1. Rossi SE, Erasmus JJ, Volpacchio M, Franquet T, Castiglioni McAdams HP. "Crazy-paving" pattern at thin-section CT of the lungs: radiologic-pathologic overview. Radiographics. 2003;23(6):1509-1519. doi:10.1148/rg.236035101 CrossRef Google Scholar
Bronchiectasis is a heterogeneous chronic lung disease, characterised by irreversible dilatation of the airways and attributed to wide spectrum other underlying conditions, usually underdiagnosed inadequately treated with high burden for both patients healthcare system. The way bronchiectasis viewed physicians has drastically changed over last decades, topic eosinophilia in context disease being one substantially highlighted. Eosinophilia was traditionally considered as means distinguishing...
<h3>Introduction and Objectives</h3> Monoclonal antibodies targeting specific inflammatory pathways have been proven to play an important role in the management of patients with respiratory diseases. Mepolizumab targets interleukin (IL) 5 is used for treatment severe eosinophilic asthma (SEA), chronic rhinosinusitis nasal polyposis (CRwNP), granulomatosis polyangiitis (EGPA), while benralizumab blocks alpha subunit IL-5 receptor SEA. Tezepelumab inhibits thymic stromal lymphopoietin has...
<h3>Introduction and Objectives</h3> Immune dysregulation is of great importance in the pathogenesis bronchiectasis. The disease mainly characterised by neutrophilic inflammation, but eosinophilia known to predominate 20% cases. Myeloid-derived suppressor cells (MDSCs) are immunomodulatory previously proven our group be altered correlated with impaired pulmonary function This study aimed investigate whether alterations novel biomarkers immune bronchiectasis clinical, laboratory, imaging...
<h3>Introduction and Objectives</h3> Idiopathic pulmonary fibrosis (IPF) is a progressive debilitating lung disease, which affects physical emotional wellbeing, while the use of specific clinical tools may aid its management. This study aimed to assess Pulmonary Fibrosis Patient Reported Outcome Measure (IPF-PROM) scale as tool interrelate depression symptoms with quality life (QoL) in IPF patients. <h3>Methods</h3> patients completed close-ended questionnaires [<i>IPF-PROM</i>, <i>Patient...
Abstract Between March and April 2020, Cyprus Greece health authorities enforced three escalated levels of public interventions to control the COVID-19 pandemic. We quantified compliance asthmatic schoolchildren from both countries intervention levels, using wearable sensors continuously track personal location physical activity. Changes in ‘fraction time spent at home’ ‘total steps/day’ were assessed with a mixed-effects model adjusting for confounders. observed significant mean increases...
<b>Background:</b> Myeloid-derived suppressor cells (MDSCs) are immunomodulatory that mainly suppress T and distinguished into HLA-DR<sup>low/-</sup>CD11b<sup>+</sup>CD33<sup>+</sup>CD15<sup>+</sup> polymorphonuclear (PMN-MDSC) HLA-DR<sup>low/-</sup>CD11b<sup>+</sup>CD33<sup>+</sup>CD14<sup>+</sup> monocytic (M-MDSC) subpopulations. Their role in the pathogenesis of bronchiectasis has not been studied yet. <b>Aims Objectives:</b> We aim to investigate involvement peripheral blood MDSCs...
<b>Background:</b> Fibrinogen and fractional exhaled nitric oxide (FeNO) are useful markers in several conditions. In a few studies, fibrinogen was described as potential marker of disease severity bronchiectasis. It is not well defined whether FeNO higher bronchiectasis than healthy individuals, it found to be lower compared other lung diseases increase only at the start exacerbations. <b>Aims Objectives:</b> We aim investigate alterations non-cystic fibrosis patients, possibly correlate...
More than 2000 CFTR pathogenic mutations have been reported in patients with Cystic Fibrosis (CF) and CFTR-related disorders (CFTR-RD) explains to some extent the clinical heterogeneity of disease. The mutation <i>p.Cys1400Ter</i> is one rare described Cyprus. We aimed define prevalence origin this local population. For genotypic analysis gene we used Devyser NGS kit on an Illumina MiSeq platform using a 150 bp paired-end reads minimum coverage 150X. Amplicon Suite software was read...