A5030967506- Tracheal and airway disorders
- Lung Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Airway Management and Intubation Techniques
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Salivary Gland Tumors Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Esophageal and GI Pathology
- Medical Imaging Techniques and Applications
- Vascular Anomalies and Treatments
- Metabolomics and Mass Spectrometry Studies
- Advanced Radiotherapy Techniques
- Coronary Interventions and Diagnostics
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer-related molecular mechanisms research
- Advanced Chemical Sensor Technologies
- Inhalation and Respiratory Drug Delivery
- Macrophage Migration Inhibitory Factor
- Dysphagia Assessment and Management
- Systemic Sclerosis and Related Diseases
- Effects of Radiation Exposure
Albert Einstein College of Medicine
2019-2025
Montefiore Medical Center
2019-2025
Washington University in St. Louis
2015
North Shore University Hospital
2014
Hofstra University
2013
Feinstein Institute for Medical Research
2011
North Shore Diabetes and Endocrine Associates
2011
Northwell Health
2010-2011
Tufts Medical Center
2010
Stanford University
2005-2007
Pulmonary hypertension (PH) is a devastating disease leading to progressive hypoxemia, right ventricular failure, and death. Hypoxia can play pivotal role in PH etiology, inducing pulmonary vessel constriction remodeling. These events lead increased wall thickness, elevated vascular resistance hypertrophy. The current study examined the association of inflammatory cytokine macrophage migration inhibitory factor (MIF) with chronic lung its development hypoxia-induced PH. We found that plasma...
Lung carcinogenesis is causally linked to cigarette smoking, in part by epigenetic changes. We tested whether accumulated change smokers apparent bronchial basal cells as of origin squamous cell carcinoma. Using an EM-seq platform covering 53.8 million CpGs (96% the entire genome) at average 7.5 sequencing reads per CpG site a single base resolution, we evaluated cytology-normal bronchoscopically brushed from situ tobacco smoke-exposed 'bronchial epithelial field' and isolated short-term...
Abstract For detecting field carcinogenesis non-invasively, early technical development and case–control testing of exhaled breath condensate microRNAs was performed. In design, human lung tissue microRNA-seq discovery reconciled with TCGA published tumor-discriminant microRNAs, yielding a panel 24 upregulated microRNAs. The airway origin topographically “fingerprinted”, using paired EBC, upper lower donor sample sets. A clinic-based study (166 NSCLC cases, 185 controls) interrogated the...
Abstract Lung diseases, including lung cancer, are rising causes of global mortality. Despite novel imaging technologies and the development biomarker assays, detection cancer remains a significant challenge. However, communicates directly with external environment releases aerosolized droplets during normal tidal respiration, which can be collected, stored analzsed as exhaled breath condensate (EBC). A few studies have suggested that EBC contains extracellular vesicles (EVs) whose microRNA...
The increasing incidence of encountering lung nodules necessitates an ongoing search for improved diagnostic procedures. Various bronchoscopic technologies have been introduced or are in development, but further studies needed to define a method that fits best clinical practice and health care systems.
Basal cells (BCs) are bronchial progenitor/stem that can regenerate injured airway that, in smokers, may undergo malignant transformation. As a model for early stages of lung carcinogenesis, we set out to characterize cytologically normal BC outgrowths from never-smokers and ever-smokers without cancers (controls), as well the epithelial "field" with anatomically remote cancers, including adenocarcinoma (LUAD) squamous cell carcinoma (LUSC) (cases).
Increased intracranial pressure (ICP) is a serious complication of variety neurologic injuries and major challenge in intensive care units.The most common causes increased ICP are: traumatic brain injury (TBI), stroke, neoplasms, hydrocephalus, hepatic encephalopathy, CNS venous return impairment, encephalitis, abscesses.Prompt diagnosis monitoring therapy this condition are essential for successful management potentially devastating condition.Recent technical innovations neuromonitoring may...
Introduction Despite many technological advances, the diagnostic yield of bronchoscopic peripheral lung nodule analysis remains limited due to frequent mispositioning. Needle-based confocal laser endomicroscopy (nCLE) enables real-time microscopic feedback on needle positioning, potentially improving sampling location and yield. Previous studies have defined validated nCLE criteria for malignancy, airway parenchyma. Larger demonstrating effect are lacking. We aim investigate if nCLE-imaging...
Despite development of multiple technologies, distinguishing benign from malignant lung nodules when they are still small in size is challenging. A high yield and minimally invasive bronchoscopic technology with low cost for diagnosis lesions needed pulmonary cancer clinical practice. Peripheral airway bronchoscopy using thin most recently ultrathin bronchoscopes improve visualization airways. The novel mobile 2D/3D C-Arm fluoroscopy system a complementary tool along radial endobronchial...
Radiotherapy is a standard treatment modality in cancer therapy, particularly for lung cancer. Diffusing alpha-emitters Radiation Therapy sources (hereafter, "Alpha DaRTs") are fixed with Ra-244 (half-life =3.6 days) that releases alpha-emitting atoms into the tumor tissue to an effective range of few millimeters.
Background: Radial probe endobronchial ultrasound (R-EBUS) is often utilized in guided bronchoscopy for the diagnosis of peripheral pulmonary lesions. R-EBUS positioning has been shown to correlate with diagnostic yield, but overall yield this technology inconsistent across published literature. Currently there no standardization image interpretation, which may result variability grading concentricity lesions and subsequently procedure performance. This was a survey-based study evaluating...
Straight-back syndrome is a rare congenital condition involving the loss of normal dorsal curvature upper thoracic spine. This leads to flattening cavity, resulting in compression underlying vasculature and airways. In this case report, we discuss management an 18-year-old male with straight-back who was referred our interventional pulmonary clinic for further his stridor apneic events. A trial airway stenting done which resolved patient's respiratory symptoms. Definitive surgical correction...
Massive hemoptysis which is presented in advanced lung diseases a life-threatening condition. Bronchial artery embolization as minimally invasive procedure the treatment of choice either first or recurrent hemoptysis. This study aimed to assess early and late efficacy bronchial angioembolization (BAE) without microcatheter.In this prospective cohort study, all patients with who had undergone BAE from August 2018 March 2019 were included. Angiographic patterns including bleeding sources,...