A5067984012- Respiratory Support and Mechanisms
- Pulmonary Hypertension Research and Treatments
- Intensive Care Unit Cognitive Disorders
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrest and Resuscitation
- Family and Patient Care in Intensive Care Units
- Cardiovascular Function and Risk Factors
- Airway Management and Intubation Techniques
- Heart Failure Treatment and Management
- Neuroscience of respiration and sleep
- Cardiovascular Issues in Pregnancy
- Obstructive Sleep Apnea Research
- Nitric Oxide and Endothelin Effects
- High Altitude and Hypoxia
- Nosocomial Infections in ICU
- Neonatal Respiratory Health Research
- Vascular Anomalies and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Eicosanoids and Hypertension Pharmacology
- Emergency and Acute Care Studies
- Sepsis Diagnosis and Treatment
- Palliative Care and End-of-Life Issues
- Systemic Sclerosis and Related Diseases
- Liver Disease and Transplantation
- Blood properties and coagulation
Tufts University
2015-2025
Tufts Medical Center
2016-2025
University Medical Center
2005-2024
Association Clinique et Thérapeutique Infantile du Val de Marne
2023-2024
Starship Children's Health
2024
Pulmonary and Critical Care Associates
1998-2022
SleepMed
2014-2022
Cambridge University Hospitals NHS Foundation Trust
2021
Addenbrooke's Hospital
2021
Boston Medical Center
1984-2020
Background: Pulmonary hypertension is a progressive and often fatal complication of the scleroderma spectrum disease for which no treatment has been proven effective in randomized trial. Objective: To determine effect epoprostenol on pulmonary secondary to disease. Design: Randomized, open-label, controlled Setting: 17 referral centers. Patients: 111 patients with moderate severe hypertension. Intervention: Epoprostenol plus conventional therapy or alone. Measurements: The primary outcome...
The need for reintubation after extubation and discontinuation of mechanical ventilation is not uncommon associated with increased mortality. Noninvasive positive-pressure has been suggested as a promising therapy patients respiratory failure extubation, but single-center, randomized trial recently found no benefit. We conducted multicenter, to evaluate the effect noninvasive on mortality in this clinical setting.
Sitaxsentan may benefit patients with pulmonary arterial hypertension by blocking the vasoconstrictor effects of endothelin-A while maintaining vasodilator/clearance functions endothelin-B receptors. Patients that was idiopathic, related to connective tissue disease or congenital heart disease, were randomized receive placebo (n = 60), sitaxsentan 100 mg 55), 300 63) orally once daily for 12 weeks. The primary endpoint change in peak VO(2) at Week 12. Secondary endpoints included 6-minute...
Noninvasive PPV has been employed for decades in patients with chronic respiratory failure. Increasing use acute failure is a more recent phenomenon, mainly because of advances noninvasive interfaces and ventilator modes. delivered by nasal or oronasal mask demonstrated to reduce the need endotracheal intubation, decrease lengths stay ICU hospital, possibly mortality. In care setting, evidence now demonstrates efficacy exacerbations COPD, pulmonary edema, contusions, who decline are not...
Objective To evaluate whether bilevel positive airway pressure, by actively assisting inhalation, more rapidly improves ventilation, acidemia, and dyspnea than continuous pressure (CPAP) in patients with acute pulmonary edema. Design Randomized, controlled, double-blind trial. Setting Emergency department a university hospital. Patients Twenty-seven patients, presenting edema, characterized dyspnea, tachypnea, tachycardia, accessory muscle use, bilateral rales, typical findings of congestion...
Dexmedetomidine is associated with less delirium than benzodiazepines and better sleep architecture either or propofol; its effect on when administered at night to patients requiring sedation remains unclear.To determine if nocturnal dexmedetomidine prevents improves in critically ill adults.This two-center, double-blind, placebo-controlled trial randomized 100 delirium-free adults receiving sedatives receive (9:30 p.m. 6:15 a.m.) intravenous (0.2 μg/kg/h, titrated by 0.1 μg /kg/h every 15...
Great differences in end-of-life practices treating the critically ill around world warrant agreement regarding major ethical principles. This analysis determines extent of worldwide consensus for practices, delineates where there is and not consensus, analyzes reasons lack consensus. Critical care societies were invited to participate. Country coordinators identified draft statements developed issues translated into six languages. Multidisciplinary responses using a web-based survey...
Small clinical trials have shown that noninvasive ventilation (NIV) is efficacious in reducing the need for intubation and improving short-term survival among patients with severe exacerbations of chronic obstructive pulmonary disease (COPD). Little known, however, about effectiveness NIV routine practice.To compare outcomes COPD treated to those invasive mechanical (IMV).This was a retrospective cohort study 25 628 hospitalized exacerbation who received on first or second hospital day at...
Importance Immune dysregulation contributes to poorer outcomes in COVID-19. Objective To investigate whether abatacept, cenicriviroc, or infliximab provides benefit when added standard care for COVID-19 pneumonia. Design, Setting, and Participants Randomized, double-masked, placebo-controlled clinical trial using a master protocol immunomodulators treatment of participants hospitalized with The results 3 substudies are reported from 95 hospitals at 85 research sites the US Latin America....
Intermittent positive pressure ventilation administered nocturnally via a nasal mask has been associated with improvements in pulmonary function and symptoms patients restrictive ventilatory disorders. We hypothesized that nocturnal (NNV) would bring about similar severe chronic obstructive disease (COPD). The study used randomized, crossover design, subjects undergoing NNV or “standard care” for sequential 3-month periods. Of 23 lung FEV1 < 1 L who were initially enrolled, 4 excluded...