Luke Howard
A5000454630- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Respiratory Support and Mechanisms
- Vascular Anomalies and Treatments
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Long-Term Effects of COVID-19
- Atrial Fibrillation Management and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Liver Disease and Transplantation
- Cardiovascular and exercise physiology
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiovascular Effects of Exercise
- Systemic Sclerosis and Related Diseases
- COVID-19 Clinical Research Studies
- Intensive Care Unit Cognitive Disorders
- High Altitude and Hypoxia
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrhythmias and Treatments
- Nitric Oxide and Endothelin Effects
- COVID-19 and Mental Health
Hammersmith Hospital
2016-2025
Imperial College Healthcare NHS Trust
2016-2025
Imperial College London
2016-2025
Lung Institute
2011-2024
Imperial Valley College
2024
University of Oxford
1993-2023
Janssen (Switzerland)
2023
Johnson & Johnson (Switzerland)
2023
University Hospitals of Leicester NHS Trust
2023
Oxford Health NHS Foundation Trust
2023
The ESC Guidelines represent the views of and were arrived at after careful consideration available evidence time they written.Health professionals are encouraged to take them fully into account when exercising their clinical judgement.The guidelines do not, however, override individual responsibility health make appropriate decisions in circumstances patients, consultation with that patient, where necessary patient's guardian or carer.It is also professional's verify rules regulations...
Guidelines and Expert Consensus Documents summarise evaluate all currently available evidence on a particular issue with the aim to assist physicians in selecting best management strategies for typical patient, suffering from given condition, taking into account impact outcome, as well risk/benefit ratio of diagnostic or therapeutic means. are no substitutes textbooks. The legal implications medical guidelines have been discussed previously. A great number issued recent years by European...
### Philosophy of the guideline Assessing patients Figure 1 Chart 1: Oxygen prescription for acutely hypoxaemic in hospital. ABG, arterial blood gas; COPD, chronic obstructive pulmonary disease; Fio2, fraction inspired oxygen; ICU, intensive care unit; NIV, non-invasive ventilation; Pco2, carbon dioxide tension; Spo2, oxygen saturation measured by pulse oximetry. View this table: Table Critical illnesses requiring high levels supplemental (see section 8.10) 2 Serious moderate if patient is...
The impact of COVID-19 on physical and mental health employment after hospitalisation with acute disease is not well understood. aim this study was to determine the effects COVID-19-related employment, identify factors associated recovery, describe recovery phenotypes. Post-hospitalisation (PHOSP-COVID) a multicentre, long-term follow-up adults (aged ≥18 years) discharged from hospital in UK clinical diagnosis COVID-19, involving an assessment between 2 7 months discharge, including detailed...
Incident pulmonary arterial hypertension was underrepresented in most registries and may have a different disease profile to prevalent disease.To determine the characteristics outcome of purely incident, treatment-naive cohort idiopathic, heritable, anorexigen-associated changes presentations survival over past decade United Kingdom Ireland.All consecutive newly diagnosed patients from 2001 2009 were identified prospectively.A total 482 (93% 5% 2% hypertension) diagnosed, giving rise an...
<b>Background and aims:</b> Glucagon-like peptide 2 (GLP-2) may improve intestinal absorption in short bowel syndrome (SBS) patients with an end jejunostomy. Teduglutide (ALX-0600), a dipeptidyl peptidase IV resistant GLP-2 analogue, prolongs the intestinotrophic properties of animal models. The safety effect teduglutide were investigated SBS without colon continuity. <b>Methods:</b> was given subcutaneously for 21 days once or twice daily to 16 per protocol investigational group, 10...
Troponin elevation is common in hospitalized COVID-19 patients, but underlying aetiologies are ill-defined. We used multi-parametric cardiovascular magnetic resonance (CMR) to assess myocardial injury recovered patients.One hundred and forty-eight patients (64 ± 12 years, 70% male) with severe infection [all requiring hospital admission, 48 (32%) ventilatory support] troponin discharged from six hospitals underwent convalescent CMR (including adenosine stress perfusion if indicated) at...
Background— Chronic thromboembolic pulmonary hypertension results from incomplete resolution of emboli. Pulmonary endarterectomy (PEA) is potentially curative, but residual following surgery common and its impact on long-term outcome poorly understood. We wanted to identify factors correlated with poor after specifically define clinically relevant post-PEA. Methods Results— Eight hundred eighty consecutive patients (mean age, 57 years) underwent PEA for chronic hypertension. Patients...
Pulmonary arterial hypertension (PAH) is a rare disorder with poor prognosis. Deleterious variation within components of the transforming growth factor-β pathway, particularly bone morphogenetic protein type 2 receptor (BMPR2), underlies most heritable forms PAH. To identify missing heritability we perform whole-genome sequencing in 1038 PAH index cases and 6385 PAH-negative control subjects. Case-control analyses reveal significant overrepresentation variants ATP13A3, AQP1 SOX17, provide...
No effective pharmacological or non-pharmacological interventions exist for patients with long COVID. We aimed to describe recovery 1 year after hospital discharge COVID-19, identify factors associated patient-perceived recovery, and potential therapeutic targets by describing the underlying inflammatory profiles of previously described clusters at 5 months discharge.
Abstract Pulmonary hypertension is defined as a mean arterial pressure of ≥25 mmHg confirmed on right heart catheterisation. Traditionally, the pulmonary systolic has been estimated echo by utilising simplified Bernoulli equation from peak tricuspid regurgitant velocity and adding this to an estimate atrial pressure. Previous studies have demonstrated correlation between that obtained invasive measurement across cohort patients. However, for individual patient significant overestimation...
Metabolic modulation with dichloroacetate improves hemodynamics in genetically susceptible patients idiopathic pulmonary arterial hypertension.
There is growing recognition of the clinical importance pulmonary haemodynamics during exercise, but several questions remain to be elucidated. The goal this statement assess scientific evidence in field order provide a basis for future recommendations.Right heart catheterisation gold standard method at rest and exercise. Exercise echocardiography cardiopulmonary exercise testing represent non-invasive tools with evolving applications. term "exercise hypertension" may most adequate describe...
The full Guideline for oxygen use in adults healthcare and emergency settings, published Thorax1 provides an update to the 2008 BTS Emergency guideline.2 following is a summary of recommendations good practice points. sections noted within this refer guideline sections. #### Philosophy 1. Assessing patients
Purpose To determine if patient survival and mechanisms of right ventricular failure in pulmonary hypertension could be predicted by using supervised machine learning three-dimensional patterns systolic cardiac motion. Materials Methods The study was approved a research ethics committee, participants gave written informed consent. Two hundred fifty-six patients (143 women; mean age ± standard deviation, 63 years 17) with newly diagnosed underwent magnetic resonance (MR) imaging, right-sided...
Rationale: Pulmonary hypertension (PH) associated with fibrotic idiopathic interstitial pneumonia (IIP; pulmonary fibrosis and nonspecific pneumonia) confers important additional morbidity mortality.Objectives: To evaluate the safety clinical efficacy of dual endothelin-1 receptor antagonist bosentan in this patient group.Methods: In a randomized, double-blind, placebo-controlled study, 60 patients IIP right heart catheter confirmed PH were randomized 2:1 to (n = 40) or placebo 20). The...
Pulmonary hypertension (PH) is a feature of variety diseases and continues to harbor high morbidity mortality. The main consequence PH right-sided heart failure which causes complex clinical syndrome affecting multiple organ systems including left heart, brain, kidneys, liver, gastrointestinal tract, skeletal muscle, as well the endocrine, immune, autonomic systems. Interorgan crosstalk interdependent mechanisms include hemodynamic consequences such reduced perfusion congestion maladaptive...
Background: Pulmonary arterial hypertension (PAH) is a heterogeneous disorder with high mortality. Methods: We conducted comprehensive study of plasma metabolites using ultraperformance liquid chromatography mass spectrometry to identify patients at risk early death, who respond well treatment, and provide novel molecular insights into disease pathogenesis. Results: Fifty-three circulating distinguished well-phenotyped idiopathic or heritable PAH (n=365) from healthy control subjects (n=121)...