Gabriella Captur
A5045750442- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Effects of Exercise
- Cardiac Valve Diseases and Treatments
- Congenital heart defects research
- COVID-19 Clinical Research Studies
- Cardiac Arrhythmias and Treatments
- Nuclear Structure and Function
- Lysosomal Storage Disorders Research
- SARS-CoV-2 and COVID-19 Research
- Cardiac electrophysiology and arrhythmias
- RNA Research and Splicing
- Noise Effects and Management
- Health disparities and outcomes
- Trypanosoma species research and implications
- Viral Infections and Immunology Research
- Cardiac Structural Anomalies and Repair
- Advanced X-ray and CT Imaging
- Studies on Chitinases and Chitosanases
- Medical Imaging Techniques and Applications
- Global Health Care Issues
- Health, Environment, Cognitive Aging
- Birth, Development, and Health
University College London
2016-2025
The Royal Free Hospital
2013-2025
MRC Unit for Lifelong Health and Ageing
2018-2025
Royal Free London NHS Foundation Trust
2020-2025
Medical Research Council
2021-2024
Williams (United Kingdom)
2024
University College Hospital
2024
Cardiovascular Institute of the South
2024
University of Leicester
2023-2024
National Health Service
2018-2023
Background— Anderson-Fabry disease (AFD) is a rare but underdiagnosed intracellular lipid disorder that can cause left ventricular hypertrophy (LVH). Lipid known to shorten the magnetic resonance imaging parameter T1. We hypothesized noncontrast T1 mapping by cardiovascular would provide novel and useful measure in this with potential detect early cardiac involvement distinguish AFD LVH from other causes. Methods Results— Two hundred twenty-seven subjects were studied: patients (n=44; 55%...
Abstract Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute the rapid clearance of SARS-CoV-2 and other infections 1–3 . Here we hypothesize pre-existing memory cell responses, cross-protective against (refs. 4–11 ), would expand in vivo support viral control, aborting infection....
Troponin elevation is common in hospitalized COVID-19 patients, but underlying aetiologies are ill-defined. We used multi-parametric cardiovascular magnetic resonance (CMR) to assess myocardial injury recovered patients.One hundred and forty-eight patients (64 ± 12 years, 70% male) with severe infection [all requiring hospital admission, 48 (32%) ventilatory support] troponin discharged from six hospitals underwent convalescent CMR (including adenosine stress perfusion if indicated) at...
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against disease, often attributed to primed cellular immunity. We investigated T B cell immunity B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) different SARS-CoV-2 infection histories....
Background: Aortic valve replacement (AVR) for aortic stenosis is timed primarily on the development of symptoms, but late surgery can result in irreversible myocardial dysfunction and additional risk. The aim this study was to determine whether presence focal scar preoperatively associated with long-term mortality. Methods: In a longitudinal observational outcome study, survival analysis performed patients severe listed intervention at 6 UK cardiothoracic centers. Patients underwent...
Myocardial fibrosis is a key mechanism of left ventricular decompensation in aortic stenosis and can be quantified using cardiovascular magnetic resonance (CMR) measures such as extracellular volume fraction (ECV%). Outcomes following valve intervention may linked to the presence extent myocardial fibrosis.This study sought determine associations between ECV% markers post-intervention clinical outcomes.Patients with severe underwent CMR, including quantification modified Look-Locker...
Abstract Aims Myocardial scar detected by cardiovascular magnetic resonance has been associated with sudden cardiac death in dilated cardiomyopathy (DCM). Certain genetic causes of DCM may cause a malignant arrhythmogenic phenotype. The concepts left ventricular (LV) (ALVC) and are currently ill-defined. We hypothesized that distinctive imaging phenotype defines ALVC. Methods results Eighty-nine patients DCM-associated mutations [desmoplakin (DSP) n = 25, filamin C (FLNC) 7, titin 30, lamin...
The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection.
Aircraft noise is a growing concern for communities living near airports. This study aimed to explore the impact of aircraft on heart structure and function. Nighttime levels (Lnight) weighted 24-hour day-evening-night (Lden) were provided by UK Civil Aviation Authority 2011. Health data came from Biobank (UKB) participants 4 major airports (London Heathrow, London Gatwick, Manchester, Birmingham) who had cardiovascular magnetic resonance (CMR) imaging starting 2014 self-reported no hearing...
Left ventricular noncompaction (LVNC) is a myocardial disorder characterized by excessive left (LV) trabeculae. Current methods for quantification of LV trabeculae have limitations. The aim this study to describe novel technique quantifying trabeculation using cardiovascular magnetic resonance (CMR) and fractal geometry. Observing that appear complex irregular, we hypothesize measuring the dimension (FD) endocardial border provides quantitative parameter can be used distinguish normal from...
Cardiovascular magnetic resonance (CMR) derived native myocardial T1 is decreased in patients with Fabry disease even before left ventricular hypertrophy (LVH) occurs and may be the first non-invasive measure of myocyte sphingolipid storage. The relationship lowering prior to other candidate early phenotype markers are unknown. Furthermore, reproducibility mapping has never been assessed disease. Sixty-three patients, 34 (54%) female, mean age 48 ± 15 years confirmed (genotyped) underwent...
T1 mapping and extracellular volume (ECV) have the potential to guide patient care serve as surrogate end-points in clinical trials, but measurements differ between cardiovascular magnetic resonance (CMR) scanners pulse sequences. To help deliver global care, we developed a phantom-based quality assurance (QA) system for verification of measurement stability over time at individual sites, with further aims generalization results across vendor systems, software versions imaging We thus...
<h3>Objective</h3> We hypothesised that abnormal global longitudinal strain (GLS) would predict outcome in hypertrophic cardiomyopathy (HCM) better than current echocardiographic measures. <h3>Methods</h3> Retrospective analysis of risk markers relation to outcomes 472 patients with HCM at a single tertiary institution (2006–2012). Exclusion criteria were left ventricular (LV) hypertrophy other origin, atrial fibrillation, lost follow-up and insufficient image quality perform analysis....
Background— Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part this phenotype and independently associated with presence sarcomere gene mutations. tested hypothesis genetic pre-LVH (genotype positive, LVH negative [G+LVH−]). Methods Results— A multicenter case–control study investigated 22 other cardiovascular magnetic resonance...
To determine how native myocardial T1 and extracellular volume (ECV) change with age, both to understand aging inform on normal reference ranges. Ninety-four healthy volunteers no a history or symptoms of cardiovascular disease diabetes underwent magnetic resonance at 1.5 T. Mid-ventricular short axis post-contrast maps by Shortened MOdified Look-Locker Inversion-recovery (ShMOLLI), Inversion Recovery (MOLLI) [pre-contrast: 5s(3s)3s, post-contrast: 4s(1s)3s(1s)2s] saturation recovery...
Background: Automated analysis of cardiac structure and function using machine learning (ML) has great potential, but is currently hindered by poor generalizability. Comparison traditionally against clinicians as a reference, ignoring inherent human inter- intraobserver error, ensuring that ML cannot demonstrate superiority. Measuring precision (scan:rescan reproducibility) addresses this. We compared humans multicenter, multi-disease, scan:rescan cardiovascular magnetic resonance data set....
Mutations in genes coding for sarcomeric proteins cause hypertrophic cardiomyopathy. Subtle abnormalities of the myocardium may be present mutation carriers without left ventricular hypertrophy (G+LVH-) but are difficult to quantify. Fractal analysis has been used define trabeculae noncompaction and identify normal racial variations. We hypothesized that measured by fractal cardiovascular magnetic resonance images abnormal G+LVH- patients, providing a preclinical marker disease...
Left ventricular maximum wall thickness (MWT) is central to diagnosis and risk stratification of hypertrophic cardiomyopathy, but human measurement prone variability. We developed an automated machine learning algorithm for MWT compared precision (reproducibility) with that 11 international experts, using a dataset patients cardiomyopathy.60 adult including those carrying cardiomyopathy gene mutations, were recruited at three institutes in the UK from August, 2018, September, 2019: Barts...