Gemma Hughes

ORCID: 0000-0003-2930-1125
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About
Contact & Profiles
Research Areas
  • Telemedicine and Telehealth Implementation
  • Healthcare Systems and Technology
  • Mental Health and Patient Involvement
  • Patient-Provider Communication in Healthcare
  • Interprofessional Education and Collaboration
  • Primary Care and Health Outcomes
  • Health Policy Implementation Science
  • Technology Use by Older Adults
  • COVID-19 and healthcare impacts
  • Innovative Approaches in Technology and Social Development
  • COVID-19 Clinical Research Studies
  • Medical Malpractice and Liability Issues
  • Healthcare Systems and Challenges
  • Health Systems, Economic Evaluations, Quality of Life
  • Information Systems Theories and Implementation
  • Healthcare innovation and challenges
  • Empathy and Medical Education
  • Health disparities and outcomes
  • Medical Research and Practices
  • Innovative Human-Technology Interaction
  • Healthcare Quality and Management
  • SARS-CoV-2 and COVID-19 Research
  • Mobile Health and mHealth Applications
  • Colorectal Cancer Surgical Treatments
  • Clinical practice guidelines implementation

University of Leicester
2023-2025

University of Oxford
2016-2024

Nuffield Health
2022

Pilgrim Hospital
2020-2021

Barts Health NHS Trust
2021

St Bartholomew's Hospital
2021

Northampton General Hospital NHS Trust
2021

Heart of England NHS Foundation Trust
2017

Centre for Mental Health
2004-2005

Background: Many promising technological innovations in health and social care are characterized by nonadoption or abandonment individuals failed attempts to scale up locally, spread distantly, sustain the innovation long term at organization system level. Objective: Our objective was produce an evidence-based, theory-informed, pragmatic framework help predict evaluate success of a technology-supported program. Methods: The study had 2 parallel components: (1) secondary research (hermeneutic...

10.2196/jmir.8775 article EN cc-by Journal of Medical Internet Research 2017-11-01
Leo Swadling Mariana O. Diniz Nathalie Schmidt Oliver E. Amin Aneesh Chandran and 95 more Emily Shaw Corinna Pade Joseph M. Gibbons Nina Le Bert Anthony T. Tan Anna Jeffery-Smith Cedric C.S. Tan C Tham Stephanie Kucykowicz Gloryanne Aidoo-Micah Joshua Rosenheim Jessica Davies Marina Johnson Melanie Jensen George Joy Laura E. McCoy Ana M. Valdes Benny Chain David Goldblatt Daniel M. Altmann Rosemary J. Boyton Charlotte Manisty Thomas A. Treibel James Moon Hakam Abbass Aderonke Abiodun Mashael Alfarih Zoe Alldis Mervyn Andiapen Jessica Artico João B. Augusto Georgina L. Baca Sasha N. L. Bailey Anish Bhuva Alex Boulter Ruth Bowles Rosemary J. Boyton Olivia V. Bracken Ben O’Brien Tim Brooks Natalie Bullock David K. Butler Gabriella Captur Nicola Champion Carmen K. M. Chan David Collier Jorge Couto de Sousa Xosé Couto‐Parada Teresa Cutino-Mogue Rhodri Davies Brooke Douglas Cecilia Di Genova Keenan Dieobi-Anene Anaya Ellis Karen Feehan Malcolm Finlay Marianna Fontana Nasim Forooghi Celia Gaier Derek W. Gilroy Matt Hamblin Gabrielle Harker Jacqueline Hewson Lauren M. Hickling Aroon D. Hingorani Lee Hamill Howes Alun D. Hughes Gemma Hughes Rebecca Hughes Ivie Itua Victor Jardim Wing-Yiu Jason Lee Melanie Jensen Jessica Jones Meleri Jones George Joy Vikas Kapil Hibba Kurdi Jonathan Lambourne Kai‐Min Lin Sarah Louth Vineela Mandadapu Áine McKnight Katia Menacho Celina Mfuko Oliver Mitchelmore Christopher Moon Diana Muñoz Sandoval Sam M. Murray Mahdad Noursadeghi Ashley Otter Susana Palma Ruth Parker Kush Patel Babita Pawarova

Abstract Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute the rapid clearance of SARS-CoV-2 and other infections 1–3 . Here we hypothesize pre-existing memory cell responses, cross-protective against (refs. 4–11 ), would expand in vivo support viral control, aborting infection....

10.1038/s41586-021-04186-8 article EN cc-by Nature 2021-11-10
Catherine J. Reynolds Corinna Pade Joseph M. Gibbons David K. Butler Ashley Otter and 95 more Katia Menacho Marianna Fontana Angelique Smit Jane E. Sackville-West Teresa Cutiño‐Moguel Mala K. Maini Benny Chain Mahdad Noursadeghi Tim Brooks Amanda Semper Charlotte Manisty Thomas A. Treibel James Moon Ana M. Valdes Áine McKnight Daniel M. Altmann Rosemary J. Boyton Hakam Abbass Aderonke Abiodun Mashael Alfarih Zoe Alldis Daniel M. Altmann Oliver E. Amin Mervyn Andiapen Jessica Artico João B. Augusto Georgina L. Baca Sasha N. L. Bailey Anish Bhuva Alex Boulter Ruth Bowles Rosemary J. Boyton Olivia V. Bracken Ben O’Brien Tim Brooks Natalie Bullock David K. Butler Gabriella Captur Nicola Champion Carmen K. M. Chan Aneesh Chandran David Collier Jorge Couto de Sousa Xosé Couto‐Parada Teresa Cutiño‐Moguel Rhodri Davies Brooke Douglas Cecilia Di Genova Keenan Dieobi-Anene Mariana O. Diniz Anaya Ellis Karen Feehan Malcolm Finlay Marianna Fontana Nasim Forooghi Celia Gaier Joseph M. Gibbons Derek W. Gilroy Matt Hamblin Gabrielle Harker Jacqueline Hewson Wendy Heywood Lauren M. Hickling Aroon D. Hingorani Lee Hamill Howes Alun D. Hughes Gemma Hughes Rebecca Hughes Ivie Itua Victor Jardim Wing-Yiu Jason Lee Melaniepetra Jensen Jessica Jones Meleri Jones George Joy Vikas Kapil Hibba Kurdi Jonathan Lambourne Kai‐Min Lin Sarah Louth Mala K. Maini Vineela Mandadapu Charlotte Manisty Áine McKnight Katia Menacho Celina Mfuko Kevin Mills Oliver Mitchelmore Christopher Moon James Moon Diana Muñoz Sandoval Sam M. Murray Mahdad Noursadeghi Ashley Otter Corinna Pade

A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...

10.1126/science.abh1282 article EN cc-by Science 2021-04-30

Failures and partial successes are common in technology-supported innovation programmes health social care. Complexity theory can help explain why. Phenomena may be simple (straightforward, predictable, few components), complicated (multiple interacting components or issues) complex (dynamic, unpredictable, not easily disaggregated into constituent components). The recently published NASSS framework applies this taxonomy to Non-adoption Abandonment of technology by individuals difficulties...

10.1186/s12916-018-1050-6 article EN cc-by BMC Medicine 2018-05-10

Establishing and running remote consultation services is challenging politically (interest groups may gain or lose), organizationally (remote consulting requires implementation work new roles workflows), economically (costs benefits are unevenly distributed across the system), technically (excellent care needs dependable links high-quality audio images), relationally (interpersonal interactions altered), clinically (patients unique, some examinations require contact, clinicians have...

10.3389/fdgth.2021.726095 article EN cc-by Frontiers in Digital Health 2021-08-13

Fewer than 1% of UK general practice consultations occur by video.To explain why video are not more widely used in practice.Analysis a sub-sample data from three mixed-method case studies remote consultation services various settings 2019-2021.The dataset included interviews and focus groups with 121 participants primary care (33 patients, 55 GPs, 11 other clinicians, nine managers, four support staff, national policymakers, five technology industry). Data were transcribed, coded...

10.3399/bjgp.2021.0658 article EN cc-by British Journal of General Practice 2022-02-16
Rishi K. Gupta Joshua Rosenheim Lucy C. K. Bell Aneesh Chandran José Afonso Guerra‐Assunção and 95 more Gabriele Pollara Matthew Whelan Jessica Artico George Joy Hibba Kurdi Daniel M. Altmann Rosemary J. Boyton Mala K. Maini Áine McKnight Jonathan Lambourne Teresa Cutiño‐Moguel Charlotte Manisty Thomas A. Treibel James Moon Benny Chain Mahdad Noursadeghi Hakam Abbass Aderonke Abiodun Mashael Alfarih Zoe Alldis Daniel M. Altmann Oliver E. Amin Mervyn Andiapen Jessica Artico João B. Augusto Georgiana Luisa Baca Sasha N. L. Bailey Anish Bhuva Alex Boulter Ruth Bowles Rosemary J. Boyton Olivia V. Bracken Ben O’Brien Tim Brooks Natalie Bullock David K. Butler Gabriella Captur Nicola Champion Carmen K. M. Chan Aneesh Chandran David Collier Jorge Couto de Sousa Xosé Couto‐Parada Teresa Cutiño‐Moguel Rhodri Davies Brooke Douglas Cecilia Di Genova Keenan Dieobi-Anene Mariana O. Diniz Anaya Ellis Karen Feehan Malcolm Finlay Marianna Fontana Nasim Forooghi Celia Gaier Joseph M. Gibbons Derek W. Gilroy Matt Hamblin Gabrielle Harker Jacqueline Hewson Lauren M. Hickling Aroon D. Hingorani Lee Hamill Howes Alun D. Hughes Gemma Hughes Rebecca Hughes Ivie Itua Victor Jardim Wing-Yiu Jason Lee Melaniepetra Jensen Jessica Jones Meleri Jones George Joy Vikas Kapil Hibba Kurdi Jonathan Lambourne Kai‐Min Lin Sarah Louth Mala K. Maini Vineela Mandadapu Charlotte Manisty Áine McKnight Katia Menacho Celina Mfuko Oliver Mitchelmore Christopher Moon James Moon Diana Muñoz Sandoval Sam M. Murray Mahdad Noursadeghi Ashley Otter Corinna Pade Susana Palma Ruth Parker Kush Patel

BackgroundWe hypothesised that host-response biomarkers of viral infections might contribute to early identification individuals infected with SARS-CoV-2, which is critical breaking the chains transmission. We aimed evaluate diagnostic accuracy existing candidate whole-blood transcriptomic signatures for infection predict positivity nasopharyngeal SARS-CoV-2 PCR testing.MethodsWe did a nested case-control study among prospective cohort health-care workers (aged ≥18 years) at St Bartholomew's...

10.1016/s2666-5247(21)00146-4 article EN cc-by The Lancet Microbe 2021-07-06

The COVID-19 pandemic-related rise in remote consulting raises questions about the nature and type of risks general practice.To develop an empirically based theory-informed taxonomy associated with consultations.Qualitative sub-study data selected from wider datasets three large, multi-site, mixed-method studies care practice before during pandemic UK.Semi-structured interviews focus groups, a total 176 clinicians 43 patients. Data were analysed thematically, taking account existing...

10.3399/bjgpo.2021.0204 article EN cc-by BJGP Open 2022-04-29

Until COVID-19, implementation and uptake of video consultations in health care was slow. However, the pandemic created a "burning platform" for scaling up such services. As organizations look to expand maintain use "new normal," it is important understand infrastructural influences changes that emerged during may influence sustainability going forward.This study aims draw lessons from 4 National Health Service (NHS) on how information infrastructures shaped, were shaped by, rapid scale-up...

10.2196/42431 article EN cc-by Journal of Medical Internet Research 2022-10-25

Introduction Research to date into assisted living technologies broadly consists of 3 generations: technical design, experimental trials and qualitative studies the patient experience. We describe a fourth-generation paradigm: in their organisational, social, political policy context. Fourth-generation are necessarily organic emergent; they view technology as part dynamic, networked potentially unstable system. They use co-design methods generate stabilise local solutions, taking account...

10.1136/bmjopen-2015-010208 article EN cc-by BMJ Open 2016-02-01

Health and care technologies often succeed on a small scale but fail to achieve widespread use (scale-up) or become routine practice in other settings (spread). One reason for this is under-theorization of the process scale-up spread, which potentially fruitful theoretical approach consider adoption as social practices.This study aimed an in-depth case assisted living explore feasibility usefulness explaining assisted-living technology across local system health care.This was individual...

10.2196/jmir.7482 article EN cc-by Journal of Medical Internet Research 2017-07-07

Requirements for physical distancing as a result of COVID-19 and the need to reduce risk infection prompted policy supporting rapid roll out video consulting across four nations UK-England, Northern Ireland, Scotland Wales. Drawing on three studies accelerated implementation uptake nations, we present comparative interpretive analysis spread scale-up during pandemic. Data include interviews with 59 national level stakeholders, 55 health social care staff 30 patients, 20 documents, responses...

10.3389/fdgth.2021.754319 article EN cc-by Frontiers in Digital Health 2021-12-20
Ben O’Brien Niall Campbell Elizabeth Allen Zahra Jamal Joanna Sturgess and 95 more Julie Sanders Charles Opondo Neil Roberts Jonathan Aron Maria Maccaroni Richard Gould Bilal H. Kirmani Ben Gibbison Gudrun Kunst Alexander Zarbock Maren Kleine‐Brueggeney Christian Stoppe Keith Pearce Mark Hughes Laura Van Dyck Richard Evans Hugh Montgomery Diana Elbourne Robert B. Henderson Jatin Desai David Keane Kurt Ruetzler Steven Stevenson R David Martinez Duncker Rosalie Magboo Nicholas Barrett Philip M. Jones Ly–Mee Yu Bob Kiaii Trudie Lobban Julie Sanders Neil Roberts Sophie Welch Christabel Williams Gemma Hughes Victoria Baker F.J. Parrondo García Chrysanthos Sfakianakis Melissa Baldey Carmen K. M. Chan Jorge Couto de Sousa Hakam Abbass Niall Campbell Linda Kimani Lajos Szentgyörgyi Louise Rankin Efstratios Athanasakis Akhila Muthuswamy Alison Allanson Anna Lewis Arron Finch Folakemi Fowe Lahja Paulus Bisma Chellam Singh Preetha Mathew Reshma Dutt Sunil Jesha Mathews Sheetal Crasta Susan M. Ferguson Schvearn Allen Seema Pokharel Anie Nicholas Adam Pailing Gudrun Kunst Harriet Noble Sian Saha Kevin O’Reilly Caitlin Spooner Emma Clarey Clare Finney Anna Broderick Maria Theresa Depante Daveena Meeks Paraskevi Pappa Laura-Anne Dymore-Brown Rebecca Samuels Tajwinder Sandhar Fatemeh Karami Annette Axalan Burt Vergara Eleanor Corcoran Mahmoud Loubani Sarah L. Ford Kay Rowe Karen Dobbs Jeanne Bulemfu Paul Harper J. Sanders Gregory Lip Bilal H. Kirmani Maureen Baker Lynne Keogan Abinash Panda Agnieszka Kotalczyk Ameenathul M. Fawzy

IMPORTANCE Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used prevent atrial fibrillation after cardiac surgery (AFACS), but not evidence-based, carries risks, and costly. OBJECTIVE To determine whether lower concentration trigger for supplementation noninferior trigger. DESIGN, SETTING, AND PARTICIPANTS This open-label, noninferiority, randomized clinical trial was conducted at 23 surgical centers the United Kingdom Germany....

10.1001/jama.2024.17888 article EN JAMA 2024-08-31

Background Remote and digital services must be equitable, but some patients have difficulty using these services. Designing measures to overcome disparities can challenging for practices. Personas (fictional cases) are a potentially useful tool in this regard. Aim To develop test set of personas reflect the lived experiences challenges that older people who disadvantaged face when navigating remote primary care Design setting Qualitative study NHS community health offering video...

10.3399/bjgp.2023.0412 article EN cc-by British Journal of General Practice 2024-01-19

<sec> <title>BACKGROUND</title> Online harm affects many people and has been associated with self-harm suicidal ideation. Although there is an emerging body of evidence that addressing adverse online experiences should be part the support offered to who are at risk suicide, little guidance date on how this might provided safe conversations can had subject. A UK charity dedicated offering emotional anyone experiencing mental discomfort, having difficulty coping, or being suicide developed a...

10.2196/preprints.72130 preprint EN cc-by 2025-02-04

A number of evaluations models integrated care have not produced the expected result reduced hospital admissions, and in some cases even found people receiving services using hospitals more than matched controls. We tested three hypotheses for these surprising results with a group 50 experts seminar: (1) problems model; (2) implementation; (3) evaluation. Our did rule out any came up advice as to manage issues. For example, model designers should rigorously test underlying logic;...

10.1177/2053434520909089 article EN International Journal of Care Coordination 2020-03-01

BackgroundLittle is known about the opportunities for shared decision-making when older high-risk patients are offered major surgery. This study examines how, when, and why clinicians can share surgery.MethodsThis was a multi-method qualitative study, combining video recordings of preoperative consultations, interviews, focus groups (33 patients, 19 relatives, 36 clinicians), with observations documentary analysis in clinics five hospitals UK undertaking orthopaedic, colorectal, and/or...

10.1016/j.bja.2023.03.022 article EN cc-by British Journal of Anaesthesia 2023-04-26

Abstract Integrated care is an aim and a method for organising health services, particularly older people those with chronic conditions. Policy expects that integrated programmes will provide person‐centred coordinated which improve patient or client experience, enable population health, prevent hospital admissions thereby reduce costs. However, empirical evaluations of interventions have shown disappointing results. We analysed in‐depth case study using Strong Structuration Theory to ask:...

10.1111/1467-9566.13398 article EN Sociology of Health & Illness 2021-11-06

Introduction Surgical treatments are being offered to more patients than ever before, and increasingly high-risk (typically multimorbid over 75). Shared decision making is seen as essential practice. However, little currently known about what ‘good’ shared involves nor how it applies in the context of surgery for patients. This new study aims identify patients, their families clinical teams negotiate major surgery. Methods analysis Focusing on joint replacement, colorectal cardiac surgery,...

10.1136/bmjopen-2019-033703 article EN cc-by-nc BMJ Open 2020-05-01

New models of care are being pursued throughout England to balance increasing demand for improved health and social services against reducing public expenditure. A dominant discourse has emerged about the value community-based integrated care, despite failures programmes consistently demonstrate reductions in hospital admissions. Discourse analysis policy establishes how issues aging, admissions fragmentation problematised, solutions made possible by argumentative structures policy. These...

10.3351/ppp.2017.6792867782 article EN People Place and Policy Online 2017-10-26
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