A5063850885- Cardiac, Anesthesia and Surgical Outcomes
- Shakespeare, Adaptation, and Literary Criticism
- Literature: history, themes, analysis
- Irish and British Studies
- Scottish History and National Identity
- Historical Art and Culture Studies
- Philippine History and Culture
- Historical Economic and Social Studies
- Cardiac Health and Mental Health
- COVID-19 and healthcare impacts
- Theatre and Performance Studies
- Cardiac Arrest and Resuscitation
- Health and Medical Research Impacts
- Heart Failure Treatment and Management
- Health Sciences Research and Education
- Hip and Femur Fractures
- Sarcoidosis and Beryllium Toxicity Research
- Financial Crisis of the 21st Century
- Travel Writing and Literature
- Frailty in Older Adults
- Intensive Care Unit Cognitive Disorders
- Joseph Conrad and Literature
- Sex and Gender in Healthcare
- Historical Studies on Reproduction, Gender, Health, and Societal Changes
- Reformation and Early Modern Christianity
St Bartholomew's Hospital
2016-2025
Barts Health NHS Trust
2016-2025
King's College London
2024-2025
Queen Mary University of London
2019-2024
William Harvey Research Institute
2019-2024
University of Nottingham
2007-2023
Newcastle University
2014-2022
University of Newcastle Australia
2018-2022
University of Southampton
2022
Monash University
2021
Interleukin-6 (IL-6) synthesized in response to diverse stimuli may play an important role bridging the inflammatory and atherosclerotic processes. The acute-phase after coronary artery bypass graft surgery (CABG) is associated with induction release of cytokines, such as IL-6. We have examined effect common polymorphisms IL-6 gene promoter (−174G>C, −572G>C, −597G>A) on levels elective CABG. DNA extracted from peripheral blood 127 patients was amplified by polymerase chain...
Many nurses and allied professionals (NAPs) lack the skills, knowledge confidence to engage in conducting implementing research. This statement describes importance of NAPs' involvement clinical research within context cardiovascular care. The existing gaps, barriers enablers NAPs as a potential response workforce issues these professions well contribute excellence patient care delivery associated outcomes are identified. Specifically, career development pathways for discussed. Finally,...
Ratings by an expert panel of the appropriateness treatments may offer better guidance for clinical practice than variable decisions individual clinicians, yet there have been no prospective studies outcomes. We compared outcomes patients treated medically after angiography with those who underwent revascularization, within groups defined ratings degree revascularization in varying circumstances.This was a study consecutive undergoing coronary at three London hospitals. Before were...
Patient-reported outcomes (PROs) provide important insights into patients' own perspectives about their health and medical condition, there is evidence that use can lead to improvements in the quality of care better-informed clinical decisions. Their application cardiovascular populations has grown over past decades. This statement describes what PROs are, it provides an inventory disease-specific domain-specific have been developed for populations. International standards indices published,...
Cardiovascular disease is a leading cause of death, morbidity, disability, and reduced health-related quality life, as well economic burden worldwide, with some 80% occurring in the low- middle-income country (LMIC) settings. With increasing numbers people living longer symptomatic disease, effectiveness accessibility secondary preventative rehabilitative health services have never been more important. Whilst LMICs experience highest prevalence mortality rates, global approach to prevention...
IMPORTANCE Supplementing potassium in an effort to maintain high-normal serum concentrations is a widespread strategy used prevent atrial fibrillation after cardiac surgery (AFACS), but not evidence-based, carries risks, and costly. OBJECTIVE To determine whether lower concentration trigger for supplementation noninferior trigger. DESIGN, SETTING, AND PARTICIPANTS This open-label, noninferiority, randomized clinical trial was conducted at 23 surgical centers the United Kingdom Germany....
Diarrhoea is common in Intensive Care Unit (ICU) patients, with a reported prevalence of 15-38%. Many factors may cause diarrhoea, including Clostridium difficile, drugs (e.g. laxatives, antibiotics) and enteral feeds. impacts on patient dignity, increases nursing workload healthcare costs, exacerbates morbidity through dermal injury, impaired uptake subsequent fluid imbalance. We analysed cohort 9331 consecutive patients admitted to mixed general intensive care unit establish the diarrhoea...
Abstract This study aimed to evaluate the sensitivity and specificity of subepidermal moisture (SEM), a biomarker employed for early detection pressure injuries (PI), compared “Gold Standard” clinical skin tissue assessment (STA), characterize timing SEM changes relative diagnosis PI. blinded, longitudinal, prospective enrolled 189 patients (n = 182 in intent‐to‐treat [ITT]) at acute post‐acute sites (9 USA, 3 UK). Data were collected from patients' heels sacrums using biocapacitance...
Abstract Background: Interleukin-6 (IL-6) concentrations vary substantially among individuals. This study aimed to identify novel genetic markers explain these differences. Methods: We sequenced a region 6-kb upstream of the IL6 [interleukin 6 (interferon, beta 2)] transcription start site in search for functional variants and detected 3 common variants: −6331T>C, −6101A>T, −5617/−5616C/A>T/G. −6331T>C (C allele frequency, 0.20; 95% confidence interval, 0.16–0.24)...
The association of red blood cell (RBC) storage on morbidity outcome after cardiac surgery is debated. We sought to clarify the age transfused in patients undergoing surgery.Data were drawn from a prospective, observational cohort study surgery. Blood transfusion data obtained retrospectively via Trust bank electronic records. Old was defined as more than 14 days old. primary measure postoperative length stay (PLOS). Secondary measures included renal failure and within survey.A total 176...
medical education must adapt to meet the challenges and demands of an ageing population, ensuring that graduates are equipped look after older patients with complex health social care needs. Recommended curricula in geriatric medicine United Kingdom Europe offer guidance for optimal undergraduate ageing. The UK version, written by British Geriatrics Society (BGS), requires updating take account innovations specialty, changing from General Medical Council (GMC), need support schools preparing...