George Joy
A5054235469- Cardiomyopathy and Myosin Studies
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiac Imaging and Diagnostics
- Long-Term Effects of COVID-19
- Cardiovascular Disease and Adiposity
- Advanced MRI Techniques and Applications
- Nuclear Structure and Function
- Congenital heart defects research
- Cardiac Valve Diseases and Treatments
- Coronary Interventions and Diagnostics
- Cardiac pacing and defibrillation studies
- Health, Environment, Cognitive Aging
- Coronary Artery Anomalies
- COVID-19 epidemiological studies
- vaccines and immunoinformatics approaches
- Cardiac electrophysiology and arrhythmias
- RNA Research and Splicing
- Viral Infections and Immunology Research
- Cardiovascular Effects of Exercise
- Cardiac Structural Anomalies and Repair
- Artificial Intelligence in Healthcare
- Atomic and Subatomic Physics Research
- RNA and protein synthesis mechanisms
St Bartholomew's Hospital
2019-2025
University College London
2020-2025
Barts Health NHS Trust
2020-2025
MRC Unit for Lifelong Health and Ageing
2023-2024
British Heart Foundation
2021-2023
Conquest Hospital
2019
King's College Hospital
2017
King's College Hospital NHS Foundation Trust
2017
Wycombe General Hospital
1993
Abstract Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute the rapid clearance of SARS-CoV-2 and other infections 1–3 . Here we hypothesize pre-existing memory cell responses, cross-protective against (refs. 4–11 ), would expand in vivo support viral control, aborting infection....
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against disease, often attributed to primed cellular immunity. We investigated T B cell immunity B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) different SARS-CoV-2 infection histories....
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 whom had captured by serial sampling. Neutralizing antibodies (nAb) were present 89% previously infected HCW. tended be lower asymptomatic than those reporting case-definition symptoms COVID-19, while nAb titers maintained irrespective...
The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection.
Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history. Healthcare workers (HCWs) may be exposed several doses and types of antigens, either natural or vaccination. Reynolds et al . studied cohort UK HCWs followed since March 2020. The immunological profiles these people depended on how often the subject had encountered antigen which variant was involved. Vaccine after were...
BackgroundSARS-CoV-2 serology is used to identify prior infection at individual and population level. Extended longitudinal studies with multi-timepoint sampling evaluate dynamic changes in antibody levels are required the time horizon which these applications of valid, explore longevity protective humoral immunity.MethodsHealthcare workers were recruited a prospective cohort study from first SARS-CoV-2 epidemic peak London, undergoing weekly symptom screen, viral PCR blood over 16–21 weeks....
BackgroundWe hypothesised that host-response biomarkers of viral infections might contribute to early identification individuals infected with SARS-CoV-2, which is critical breaking the chains transmission. We aimed evaluate diagnostic accuracy existing candidate whole-blood transcriptomic signatures for infection predict positivity nasopharyngeal SARS-CoV-2 PCR testing.MethodsWe did a nested case-control study among prospective cohort health-care workers (aged ≥18 years) at St Bartholomew's...
BackgroundThe majority of those infected by ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require hospitalisation. Most had a short-lived mild or asymptomatic infection, while others symptoms that persisted for weeks months. We hypothesized plasma proteome at time infection would reflect differences in inflammatory response linked to symptom severity and duration.MethodsWe performed nested longitudinal...
In hypertrophic cardiomyopathy (HCM), myocyte disarray and microvascular disease (MVD) have been implicated in adverse events, recent evidence suggests that these may occur early. As novel therapy provides promise for modification, detection of phenotype development is an emerging priority. To evaluate their utility as early disease-specific biomarkers, we measured myocardial microstructure MVD 3 HCM groups-overt, either genotype-positive (G+LVH+) or genotype-negative (G-LVH+), subclinical...
Among the unknowns in decoding pathogenesis of SARS-CoV-2 persistent symptoms Long Covid is whether there a contributory role abnormal immunity during acute infection. It has been proposed that consequence either an excessive or inadequate initial immune response. Here, we analyze humoral and cellular 86 healthcare workers with laboratory confirmed mild asymptomatic infection first wave. Symptom questionnaires allow stratification into those without for comparison. During period up to...
Abstract SARS‐CoV‐2 infection results in different outcomes ranging from asymptomatic to mild or severe disease and death. Reasons for this diversity of outcome include differences challenge dose, age, gender, comorbidity host genomic variation. Human leukocyte antigen (HLA) polymorphisms may influence immune response outcome. We investigated the association HLAII alleles with case definition symptomatic COVID‐19, virus‐specific antibody T‐cell immunity. A total 1364 UK healthcare workers...
Background: Apical hypertrophic cardiomyopathy (ApHCM) accounts for ≈10% of cases and is characterized by apical hypertrophy, cavity obliteration, tall ECG R waves with ischemic-looking deep T-wave inversion. These may be present even <15 mm hypertrophy (relative ApHCM). Microvascular dysfunction well described in cardiomyopathy. We hypothesized that perfusion defects would common ApHCM. Methods: A 2-center study using cardiovascular magnetic resonance short- long-axis quantitative...
Ventricular arrhythmia in hypertrophic cardiomyopathy (HCM) relates to adverse structural change and genetic status. Cardiovascular magnetic resonance (CMR)–guided electrocardiographic imaging (ECGI) noninvasively maps cardiac electrophysiological (EP) properties. The purpose of this study was establish whether subclinical HCM (genotype [G]+ left ventricular hypertrophy [LVH]−), ECGI detects early EP abnormality, overt HCM, the substrate status (G+/G−LVH+) phenotype. This a prospective...
The purpose of this study was to explore the prognostic significance PTT and PBVi using an automated, inline method estimation CMR. Pulmonary transit time (PTT) pulmonary blood volume index (PBVi) (the product cardiac index), are quantitative biomarkers cardiopulmonary status. development cardiovascular magnetic resonance (CMR) perfusion mapping permits their automated derivation, facilitating clinical adoption. In retrospective 2-center patients referred for myocardial assessment CMR,...
Abstract Individuals with likely exposure to the highly infectious SARS-CoV-2 do not necessarily develop PCR or antibody positivity, suggesting some may clear sub-clinical infection before seroconversion. T cells can contribute rapid clearance of and other coronavirus infections 1–5 . We hypothesised that pre-existing memory cell responses, cross-protective potential against 6–12 , would expand in vivo mediate viral control, potentially aborting infection. studied replication transcription...
Background Impaired myocardial blood flow (MBF) in the absence of epicardial coronary disease is a feature hypertrophic cardiomyopathy (HCM). Although most evident hypertrophied or scarred segments, reduced MBF can occur apparently normal segments. We hypothesized that impaired and perfusion reserve, quantified using mapping cardiac magnetic resonance, might overt left ventricular hypertrophy (LVH) late gadolinium enhancement, mutation carriers without LVH criteria for HCM...
Microvascular dysfunction in hypertrophic cardiomyopathy (HCM) is predictive of clinical decline, however underlying mechanisms remain unclear. Cardiac diffusion tensor imaging (cDTI) allows vivo characterization myocardial microstructure by quantifying mean diffusivity (MD), fractional anisotropy (FA) diffusion, and secondary eigenvector angle (E2A). In this cardiac magnetic resonance (CMR) study, we examine associations between perfusion cDTI parameters to understand the sequence...