Stephen R. Thomas
A5012971192- Particle Detector Development and Performance
- Advanced MRI Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- Radiation Dose and Imaging
- Medical Imaging Techniques and Applications
- COVID-19 Clinical Research Studies
- Radiation Detection and Scintillator Technologies
- Radiopharmaceutical Chemistry and Applications
- CCD and CMOS Imaging Sensors
- Neuroscience and Neuropharmacology Research
- Advanced Radiotherapy Techniques
- Advanced X-ray and CT Imaging
- Pneumonia and Respiratory Infections
- Radiation Effects in Electronics
- Electron Spin Resonance Studies
- Diabetes Management and Research
- Respiratory viral infections research
- Asthma and respiratory diseases
- Nuclear Physics and Applications
- Cardiac Imaging and Diagnostics
- Bacterial Infections and Vaccines
- Atomic and Subatomic Physics Research
- Tuberculosis Research and Epidemiology
- Memory and Neural Mechanisms
- Bacteriophages and microbial interactions
Istituto Nazionale di Fisica Nucleare, Sezione di Bari
2024
UK Health Security Agency
2021-2023
Public Health England
2015-2021
Guy's Hospital
2021
Raigmore Hospital
2018-2021
NHS Highland
2020-2021
Bristol Royal Infirmary
2020
SUNY Upstate Medical University
2019
Fermi National Accelerator Laboratory
2019
Rutherford Appleton Laboratory
1999-2018
Adjustments of the standard helical CT protocols for adults can result in reduced radiation dose when imaging children. It is radiologist's responsibility to critically evaluate techniques used at their institution. should be made choose appropriate mA and pitch
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved spread West Africa. Miles Carroll colleagues report describe the genetic evolution circulating Africa, based on 2015. Their analysis Africa Sierra Leone, Liberia. is currently witnessing most extensive (EBOV) outbreak so far recorded1,2,3. Until now, there have been 27,013 reported cases 11,134 deaths. The origin thought to a zoonotic...
There is a vital need for authentic COVID-19 animal models to enable the pre-clinical evaluation of candidate vaccines and therapeutics. Here we report dose titration study SARS-CoV-2 in ferret model. After high (5 × 106 pfu) medium 104 virus delivered, intranasally, viral RNA shedding upper respiratory tract (URT) observed 6/6 animals, however, only 1/6 ferrets show similar signs after low 102 challenge. Following sequential culls pathological mild multifocal bronchopneumonia approximately...
A novel coronavirus, SARS-CoV-2, has been identified as the causative agent of current COVID-19 pandemic. Animal models, and in particular non-human primates, are essential to understand pathogenesis emerging diseases assess safety efficacy vaccines therapeutics. Here, we show that SARS-CoV-2 replicates upper lower respiratory tract causes pulmonary lesions both rhesus cynomolgus macaques. Immune responses against also similar species equivalent those reported milder infections convalescent...
Renal toxicity associated with small-molecule radionuclide therapy has been shown to be dose-limiting for many clinical studies. Strategies maximizing dose the target tissues while sparing normal critical organs based on absorbed and biologic response parameters are commonly used in external-beam therapy. However, radiopharmaceuticals passing though kidneys result a differential rate suborgan elements, presenting significant challenge assessing an accurate dose–response relationship that is...
BackgroundThe novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, initiates infection in the upper tract (URT). Infected individuals are often asymptomatic, yet highly infectious and readily transmit virus. A therapy that restricts initial replication URT has potential to prevent progression of severe lower disease as well limiting person-to-person transmission.MethodsSARS-CoV-2 Victoria/01/2020 was passaged Vero/hSLAM...
BackgroundSARS-CoV-2 serology is used to identify prior infection at individual and population level. Extended longitudinal studies with multi-timepoint sampling evaluate dynamic changes in antibody levels are required the time horizon which these applications of valid, explore longevity protective humoral immunity.MethodsHealthcare workers were recruited a prospective cohort study from first SARS-CoV-2 epidemic peak London, undergoing weekly symptom screen, viral PCR blood over 16–21 weeks....
Rhenium-186(tin) hydroxyethylidene diphosphonate (HEDP) is a new radiopharmaceutical that localizes in areas of osseous metastases manner similar to standard bone-scanning agents. It also emits beta particles with sufficient energy be therapeutically useful. A single intravenous injection about 33 mCi (1,221 MBq) was given each 20 elderly patients advanced skeletal from hormonally resistant prostate cancer. Prompt, significant relief pain occurred 80% the time no side effects and only...
The mutation profile of the SARS-CoV-2 Omicron (lineage BA.1) variant posed a concern for naturally acquired and vaccine-induced immunity. We investigated ability prior infection with an early ancestral isolate (Australia/VIC01/2020, VIC01) to protect against disease caused by BA.1. established that BA.1 in naïve Syrian hamsters resulted less severe than comparable dose virus, fewer clinical signs including weight loss. present data show these observations were almost absent convalescent...
Certain perfluorocarbon (PFC) compounds, commonly used as the oxygen transport components of "blood substitutes," may be breathed neat liquids with survival because their chemical inertness and high solubility for carbon dioxide. In addition, paramagnetism reduces fluorine T1 value according to an inverse relationship allowing a potential method monitoring Po2 gradients in vivo. This article presents results magnetic resonance (MR) imaging lungs mice rats following breathing four PFC (FC-43,...
We report 2 cases of Ebola viral disease (EVD) in pregnant women who survived, initially with intact pregnancies. Respectively 31–32 days after negativation the maternal blood EVD-polymerase chain reaction (PCR) both patients delivered a stillborn fetus persistent EVD-PCR amniotic fluid positivity.
Abstract In December 2019 an outbreak of coronavirus disease (COVID-19) emerged in Wuhan, China. The causative agent was subsequently identified and named severe acute respiratory syndrome 2 (SARS-CoV-2) which rapidly spread worldwide causing a pandemic. Currently there are no licensed vaccines or therapeutics available against SARS-CoV-2 but numerous candidate development repurposed drugs being tested the clinic. There is vital need for authentic COVID-19 animal models to further our...
We present the development and prototype test of LPD instrument, a novel pixel detector for European XFEL. At XFEL must be capable operating with frame rate 4.5MHz record images dynamic range 1:100,000 photons (12keV) whilst maintaining low noise. The system has large in memory depth 512 that can selected flexible veto system. Data is then transferred off head between pulses an accompanying high data acquisition been prototyped assembled into contains custom silicon sensors ASICs as well...