Teresa Cutiño‐Moguel
A5057242759- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- vaccines and immunoinformatics approaches
- Long-Term Effects of COVID-19
- COVID-19 and Mental Health
- Infection Control and Ventilation
- Respiratory viral infections research
- Animal Virus Infections Studies
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Influenza Virus Research Studies
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Diabetes and associated disorders
- COVID-19 Impact on Reproduction
- Immune responses and vaccinations
- Polyomavirus and related diseases
- Inflammasome and immune disorders
- Artificial Intelligence in Healthcare
- Celiac Disease Research and Management
- Parvovirus B19 Infection Studies
Barts Health NHS Trust
2020-2024
St Bartholomew's Hospital
2020-2022
Royal London Hospital
2020-2022
Genomics (United Kingdom)
2022
Queen Mary University of London
2022
University College Hospital
2017
University College London
2006-2017
University of Cambridge
2014
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2002
Vaccines based on the spike protein of SARS-CoV-2 are a cornerstone public health response to COVID-19. The emergence hypermutated, increasingly transmissible variants concern (VOCs) threaten this strategy. Omicron (B.1.1.529), fifth VOC be described, harbours multiple amino acid mutations in spike, half which lie within receptor-binding domain. Here we demonstrate substantial evasion neutralization by BA.1 and BA.2 vitro using sera from individuals vaccinated with ChAdOx1, BNT162b2...
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against disease, often attributed to primed cellular immunity. We investigated T B cell immunity B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) different SARS-CoV-2 infection histories....
Understanding the nature of immunity following mild/asymptomatic infection with SARS-CoV-2 is crucial to controlling pandemic. We analyzed T cell and neutralizing antibody responses in 136 healthcare workers (HCW) 16-18 weeks after United Kingdom lockdown, 76 whom had captured by serial sampling. Neutralizing antibodies (nAb) were present 89% previously infected HCW. tended be lower asymptomatic than those reporting case-definition symptoms COVID-19, while nAb titers maintained irrespective...
Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history. Healthcare workers (HCWs) may be exposed several doses and types of antigens, either natural or vaccination. Reynolds et al . studied cohort UK HCWs followed since March 2020. The immunological profiles these people depended on how often the subject had encountered antigen which variant was involved. Vaccine after were...
BackgroundSARS-CoV-2 serology is used to identify prior infection at individual and population level. Extended longitudinal studies with multi-timepoint sampling evaluate dynamic changes in antibody levels are required the time horizon which these applications of valid, explore longevity protective humoral immunity.MethodsHealthcare workers were recruited a prospective cohort study from first SARS-CoV-2 epidemic peak London, undergoing weekly symptom screen, viral PCR blood over 16–21 weeks....
BackgroundWe hypothesised that host-response biomarkers of viral infections might contribute to early identification individuals infected with SARS-CoV-2, which is critical breaking the chains transmission. We aimed evaluate diagnostic accuracy existing candidate whole-blood transcriptomic signatures for infection predict positivity nasopharyngeal SARS-CoV-2 PCR testing.MethodsWe did a nested case-control study among prospective cohort health-care workers (aged ≥18 years) at St Bartholomew's...
Abstract The emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is public health concern in case vaccine escape. Described are 3 patients with advanced human immunodeficiency virus (HIV)-1 and chronic SARS-CoV-2 infection whom there evidence selection persistence novel mutations that associated increased transmissibility immune
Abstract Background Haemodialysis (HD) patients are extremely vulnerable to coronavirus disease 2019 (COVID-19). Their immune response after infection is unclear. We have found high seroconversion rates in this population, with 95% developing antibodies. It unclear if and how long these antibodies persist. Here we investigate serial antibody (Ab) testing. Methods identified HD who had confirmedsevere acute respiratory syndrome 2 between March May 2020 measured monthly (immunoglobulin...
<ns3:p><ns3:bold>Background</ns3:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: conducted prospective study HCWs from three sites in London, initially at...
<ns4:p><ns4:bold>Background</ns4:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: conducted prospective observational study HCWs from three sites in London,...
ObjectivesRecently emerging SARS-CoV-2 variants have been associated with an increased rate of transmission within the community. We sought to determine whether this also resulted in hospitals.MethodsWe collected viral sequences and epidemiological data patients community healthcare infections, sampled from 16th November 2020 10th January 2021, nine hospitals participating COG-UK HOCI study. Outbreaks were identified using ward information, lineage pairwise genetic differences between...
Introduction: SARS-CoV-2 antibody detection serves as an important diagnostic marker for past infection and is essential to determine the spread of COVID-19, monitor potential COVID-19 long-term effects, evaluate possible protection from reinfection. A study was conducted across three hospital sites in a large central London NHS Trust UK, prevalence duration IgG positivity healthcare workers. Methods: matrix equivalence consisting 228 participants undertaken Abbott Panbio™ IgG/IgM rapid test...
Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding changing response. We devised informative assay current ELISA-based serology using multiplexed, baited, targeted proteomics direct detection multiple proteins in SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- second-dose...
Rabbit cells are poorly permissive to HIV‐1 infection, but little is known about the nature of this block. Here, we show that block infection mainly at level reverse transcription (RT), independent cell receptor used by virus for entry, cannot be effectively saturated with high doses or virus‐like particles, and has a recessive phenotype in human–rabbit heterokaryons. RT complexes (RTCs) extracted from human rabbit have different densities both competent an vitro endogenous assay. Cell...
Abstract Studies of adaptive immunity to SARS-CoV-2 include characterisation lethal, severe and mild cases 1-8 . Understanding how long lasts in people who have had or asymptomatic infection is crucial. Healthcare worker (HCW) cohorts exposed infected by during the early stages pandemic are an invaluable resource study this question 9-14 The UK COVIDsortium a longitudinal, London hospital HCW cohort, followed from time lockdown 9,10 ; weekly PCR, serology symptom diaries allowed capture...
ABSTRACT The emergence of new SARS-COV-2 variants is public health concern in case vaccine escape. Described are three patients with advanced HIV-1 and chronic SARS-CoV-2 infection whom there evidence selection persistence novel mutations which associated increased transmissibility immune
Abstract We hypothesised that host-response biomarkers of viral infections may contribute to early identification SARS-CoV-2 infected individuals, critical breaking chains transmission. identified 20 candidate blood transcriptomic signatures infection by systematic review and evaluated their ability detect infection, compared the gold-standard virus PCR tests, among a prospective cohort 400 hospital staff subjected weekly testing when fit attend work. The transcriptional had limited overlap,...