Katia Menacho
A5071035132- Cardiac Imaging and Diagnostics
- Advanced MRI Techniques and Applications
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Cardiovascular Function and Risk Factors
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Long-Term Effects of COVID-19
- vaccines and immunoinformatics approaches
- Coronary Interventions and Diagnostics
- Cellular transport and secretion
- Cardiac Structural Anomalies and Repair
- Infection Control and Ventilation
- Lysosomal Storage Disorders Research
- Trypanosoma species research and implications
- Hemoglobinopathies and Related Disorders
- COVID-19 epidemiological studies
- Congenital Heart Disease Studies
- HIV/AIDS drug development and treatment
- Infrared Thermography in Medicine
- SARS-CoV-2 detection and testing
- Pulmonary Hypertension Research and Treatments
- HIV-related health complications and treatments
- Non-Invasive Vital Sign Monitoring
- Pneumocystis jirovecii pneumonia detection and treatment
University College London
2018-2025
British Heart Foundation
2018-2024
St Bartholomew's Hospital
2017-2023
Barts Health NHS Trust
2020-2022
Royal London Hospital
2021
Abstract Individuals with potential exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) do not necessarily develop PCR or antibody positivity, suggesting that some individuals may clear subclinical infection before seroconversion. T cells can contribute the rapid clearance of SARS-CoV-2 and other infections 1–3 . Here we hypothesize pre-existing memory cell responses, cross-protective against (refs. 4–11 ), would expand in vivo support viral control, aborting infection....
A boost from infection During clinical trials of severe acute respiratory syndrome coronavirus 2 vaccines, no one who had survived with the virus was tested. year after pandemic declared, vaccination previously infected persons is a reality. Reynolds et al. address knowledge gap in cohort UK health care workers given Pfizer/BioNTech vaccine which half participants experienced natural infections early (see Perspective by Crotty). Genotyping indicated that genetic component underlies...
The Omicron, or Pango lineage B.1.1.529, variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) carries multiple spike mutations with high transmissibility and partial neutralizing antibody (nAb) escape. Vaccinated individuals show protection against disease, often attributed to primed cellular immunity. We investigated T B cell immunity B.1.1.529 in triple BioNTech BNT162b2 messenger RNA-vaccinated health care workers (HCWs) different SARS-CoV-2 infection histories....
To investigate myocardial fibrosis (MF) in a large series of severe aortic stenosis (AS) patients using invasive biopsy and non-invasive imaging.One hundred thirty-three with severe, symptomatic AS accepted for surgical valve replacement underwent cardiovascular magnetic resonance (CMR) late gadolinium enhancement (LGE) extracellular volume fraction (ECV) quantification. Intra-operative left ventricular (LV) biopsies were performed by needle or scalpel, yielding tissue (n = 53) without...
The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome-coronavirus-2 infection.
Immune imprinting For severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune responses to heterologous variants are influenced by a person’s infection history. Healthcare workers (HCWs) may be exposed several doses and types of antigens, either natural or vaccination. Reynolds et al . studied cohort UK HCWs followed since March 2020. The immunological profiles these people depended on how often the subject had encountered antigen which variant was involved. Vaccine after were...
BackgroundWe hypothesised that host-response biomarkers of viral infections might contribute to early identification individuals infected with SARS-CoV-2, which is critical breaking the chains transmission. We aimed evaluate diagnostic accuracy existing candidate whole-blood transcriptomic signatures for infection predict positivity nasopharyngeal SARS-CoV-2 PCR testing.MethodsWe did a nested case-control study among prospective cohort health-care workers (aged ≥18 years) at St Bartholomew's...
BackgroundThe majority of those infected by ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) during the UK first wave (starting March 2020) did not require hospitalisation. Most had a short-lived mild or asymptomatic infection, while others symptoms that persisted for weeks months. We hypothesized plasma proteome at time infection would reflect differences in inflammatory response linked to symptom severity and duration.MethodsWe performed nested longitudinal...
Fabry disease (FD) is a rare and treatable X-linked lysosomal storage disorder. Cardiac involvement determines outcomes; therefore, detecting early changes important. Native T1 by cardiovascular magnetic resonance low, reflecting sphingolipid storage. Early phenotype development familiar in hypertrophic cardiomyopathy but unexplored FD. We explored the prehypertrophic cardiac of FD role storage.A prospective, international multicenter observational study 100 left ventricular...
The purpose of this study was to explore the prognostic significance PTT and PBVi using an automated, inline method estimation CMR. Pulmonary transit time (PTT) pulmonary blood volume index (PBVi) (the product cardiac index), are quantitative biomarkers cardiopulmonary status. development cardiovascular magnetic resonance (CMR) perfusion mapping permits their automated derivation, facilitating clinical adoption. In retrospective 2-center patients referred for myocardial assessment CMR,...
To evaluate the impact of a simplified, rapid cardiovascular magnetic resonance (CMR) protocol embedded in care and supported by partner education programme on management cardiomyopathy (CMP) low- middle-income countries (LMICs).Rapid CMR focused particularly CMP was implemented 11 centres, 7 cities, 5 countries, 3 continents linked to training courses for local professionals. Patients were followed up 24 months assess impact. The rate subsequent adoption tracked. Five conferences delivered...
Abstract Background Serial surveillance screening for cardiotoxicity demands measurement precision to detect dysfunction early and avoid inappropriate treatment interruptions. 3D LVEF GLS imaging are therefore recommended, or CMR where image quality is suboptimal [1]. Automated (AI) analysis of has demonstrated ‘superhuman’ [2], however the impact AI on echocardiographic unknown. Purpose To compare human versus using echocardiography in oncology patients at risk cardiotoxicity. Methods Adult...
Background Advanced cardiac imaging permits optimal targeting of treatment but needs to be faster, cheaper, and easier for global delivery. We aimed pilot rapid magnetic resonance ( CMR ) with contrast in a developing nation, embedding it within clinical care along training mentoring. Methods Results A cross-sectional study delivery impact assessment performed 2016-2017 an upper middle-income country. An International partnership (clinicians Peru collaborators from the United Kingdom,...
<ns3:p><ns3:bold>Background</ns3:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns3:p><ns3:p> <ns3:bold>Methods</ns3:bold>: conducted prospective study HCWs from three sites in London, initially at...
<ns4:p><ns4:bold>Background</ns4:bold>: Most biomedical research has focused on sampling COVID-19 patients presenting to hospital with advanced disease, less focus the asymptomatic or paucisymptomatic. We established a bioresource serial of health care workers (HCWs) designed obtain samples before and during mainly mild follow-up evaluate quality duration immune memory.</ns4:p><ns4:p> <ns4:bold>Methods</ns4:bold>: conducted prospective observational study HCWs from three sites in London,...
Aims Marathon running is a popular ambition in modern societies inclusive of non-athletes. Previous studies have highlighted concerning transient myocardial dysfunction and biomarker release immediately after the race. Whether this method increasing physical activity beneficial or harmful remains matter debate. We examine detail cardiovascular remodelling response following competition first marathon. Methods Sixty-eight novice marathon runners aged 30 ±3 years were investigated 6 months...
Determining the protection an individual has to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants of concern (VoCs) is crucial for future immune surveillance, vaccine development, and understanding changing response. We devised informative assay current ELISA-based serology using multiplexed, baited, targeted proteomics direct detection multiple proteins in SARS-CoV-2 anti-spike antibody immunocomplex. Serum from individuals collected after infection or first- second-dose...
Background: Measurement of myocardial T1 is increasingly incorporated into standard cardiovascular magnetic resonance (CMR) protocols, however accuracy may be reduced in patients with metallic implants. feasible segments free from visual artifact, but there still off-resonance induced error. Aim: To quantify error implants, and validate a method for correction conventional MOLLI pulse sequence. Methods: Twenty-four cardiac implantable electronic devices (CIEDs: 46% permanent pacemakers,...