A5101518296- Antimicrobial Resistance in Staphylococcus
- Bacterial Identification and Susceptibility Testing
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 epidemiological studies
- Bacterial biofilms and quorum sensing
- Antibiotic Use and Resistance
- COVID-19 and healthcare impacts
- Infection Control and Ventilation
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Animal Virus Infections Studies
- Nosocomial Infections in ICU
- Primary Care and Health Outcomes
- Infective Endocarditis Diagnosis and Management
- Innovations in Medical Education
- Data-Driven Disease Surveillance
- Infection Control in Healthcare
- Healthcare Policy and Management
- Mycobacterium research and diagnosis
- Streptococcal Infections and Treatments
- Microbial Metabolism and Applications
- Urinary Tract Infections Management
- Empathy and Medical Education
Brighton and Sussex Medical School
2009-2025
University of Sussex
2008-2025
Imperial College London
2020-2023
Imperial College Healthcare NHS Trust
2020-2023
National Institute for Health Research
2020-2023
University Hospitals Sussex NHS Foundation Trust
2009-2023
University of Brighton
2023
Public Health England
2017-2022
Quadram Institute
2022
St Mary's Hospital
2020-2022
Whole-genome sequencing (WGS) could potentially provide a single platform for extracting all the information required to predict an organism's phenotype. However, its ability accurate predictions has not yet been demonstrated in large independent studies of specific organisms. In this study, we aimed develop genotypic prediction method antimicrobial susceptibilities. The whole genomes 501 unrelated Staphylococcus aureus isolates were sequenced, and assembled interrogated using BLASTn panel...
We evaluated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) surface and air contamination during the disease 2019 (COVID-19) pandemic in London.
BackgroundHealth-care workers have been implicated in nosocomial outbreaks of Staphylococcus aureus, but the dearth evidence from non-outbreak situations means that routine health-care worker screening and S aureus eradication are controversial. We aimed to determine how often is transmitted or environment patients an intensive care unit (ICU) a high-dependency (HDU) where standard infection control measures were place.MethodsIn this longitudinal cohort study, we systematically sampled...
Oceanic overflows are bottom-trapped density currents originating in semienclosed basins, such as the Nordic seas, or on continental shelves, Antarctic shelf. Overflows source of most abyssal waters, and therefore play an important role large-scale ocean circulation, forming a component sinking branch thermohaline circulation. As they descend slope, mix vigorously with surrounding oceanic changing their transport significantly. These mixing processes occur spatial scales well below...
Background. Strategies to prevent Staphylococcus aureus infection in hospitals focus on patient-to-patient transmission. We used whole-genome sequencing investigate the role of colonized patients as source new S. acquisitions, and reliability identifying transmission using conventional approach spa typing overlapping patient stay.
Bacteria responsible for the greatest global mortality colonize human microbiota far more frequently than they cause severe infections. Whether mutation and selection among commensal bacteria are associated with infection is unknown. We investigated de novo in 1163 Staphylococcus aureus genomes from 105 infected patients nose colonization. report that 72% of infections emerged nose, infecting nose-colonizing showing parallel adaptive differences. found 2.8-to-3.6-fold enrichments...
Background Evaluation of SARS-CoV-2 surface and air contamination during the COVID-19 pandemic in London. Methods We performed this prospective cross-sectional observational study a multi-site London hospital. Air samples were collected from seven clinical areas, occupied by patients with COVID-19, public area Three or four 1.0 m3 each using an active sampler. Surface swabbing items immediate vicinity sample. was detected RT-qPCR viral culture; limit detection for culturing surfaces...
ABSTRACT Background Evaluation of SARS-CoV-2 surface and air contamination during the COVID-19 pandemic in London. Methods We performed this prospective cross-sectional observational study a multi-site London hospital. Air samples were collected from seven clinical areas, occupied by patients with COVID-19, public area Three or four 1.0 m 3 each using an active sampler. Surface swabbing items immediate vicinity sample. was detected RT-qPCR viral culture; limit detection for culturing...
We examined community- and hospital-acquired bloodstream infections (BSIs) in coronavirus disease 2019 (COVID-19) non-COVID-19 patients across 2 epidemic waves.We analyzed blood cultures of presenting to a London hospital group between January 2020 February 2021. reported BSI incidence, changes sampling, case mix, healthcare capacity, COVID-19 variants.We identified 1047 BSIs from 34 044 cultures, including 653 (62.4%) community-acquired 394 (37.6%) hospital-acquired. Important pattern were...
Background SARS-CoV-2 lineage B.1.1.7 has been associated with an increased rate of transmission and disease severity among subjects testing positive in the community. Its impact on hospitalised patients is less well documented. Methods We collected viral sequences clinical data admitted hospital-onset COVID-19 infections (HOCIs), sampled 16 November 2020 to 10 January 2021, from eight hospitals participating COG-UK-HOCI study. Associations between variant outcomes all-cause mortality...
Background Here we report on a process evaluation conducted as part of large multisite non-randomised trial the effectiveness novel whole genome sequence form (SRF) to reduce nosocomial SARS-CoV-2 through changing infection prevention and control (IPC) behaviours during COVID –19 pandemic. We detail how SRF was implemented across heterogeneous purposive sub-sample hospital sites (n=5/14). Methods in-depth interviews from diverse professional staff (N=39). Deductive inductive thematic...
New strains of meticillin-resistant Staphylococcus aureus (MRSA) may be associated with changes in rates disease or clinical presentation. Conventional typing techniques not detect new clonal variants that underlie epidemiology phenotype.To investigate the role MRSA an outbreak bacteraemia at a hospital England.Bacteraemia isolates major UK lineages (EMRSA-15 and -16) from before after were analysed by whole-genome sequencing context epidemiological data. For comparison, EMRSA-15 -16 another...