J. Goldstein
A5107390071- Particle physics theoretical and experimental studies
- High-Energy Particle Collisions Research
- Quantum Chromodynamics and Particle Interactions
- Particle Detector Development and Performance
- Dark Matter and Cosmic Phenomena
- Cosmology and Gravitation Theories
- Computational Physics and Python Applications
- Neutrino Physics Research
- Radiation Detection and Scintillator Technologies
- Astrophysics and Cosmic Phenomena
- Black Holes and Theoretical Physics
- Medical Imaging Techniques and Applications
- Monoclonal and Polyclonal Antibodies Research
- CCD and CMOS Imaging Sensors
- Particle Accelerators and Free-Electron Lasers
- Distributed and Parallel Computing Systems
- Diamond and Carbon-based Materials Research
- Immunotherapy and Immune Responses
- Radiation Effects in Electronics
- Protein purification and stability
- Superconducting Materials and Applications
- Cancer Immunotherapy and Biomarkers
- Atomic and Subatomic Physics Research
- Advanced Data Storage Technologies
- CAR-T cell therapy research
University of Bristol
2016-2025
Celldex Therapeutics (United States)
2016-2025
Institute of High Energy Physics
2015-2024
A. Alikhanyan National Laboratory
2022-2024
University of Antwerp
2024
At Bristol
2024
Rutherford Appleton Laboratory
2003-2023
Southwest Research Institute
2021-2022
University of Liverpool
1996-2021
The University of Texas at San Antonio
2021
The design and construction of the silicon strip microvertex detector (SMD) L3 experiment at LEP are described. We present sensors, readout electronics, data acquisition system, mechanical assembly support, displacement monitoring systems radiation system recently installed double-sided, double-layered SMD. This utilizes novel sophisticated techniques for its readout.
The Compact Linear Collider (CLIC) is an option for a future $${\mathrm{e}^{+}}{\mathrm{e}^{-}} $$ collider operating at centre-of-mass energies up to $$3\,\text {TeV} , providing sensitivity wide range of new physics phenomena and precision measurements the energy frontier. This paper first comprehensive presentation Higgs reach CLIC three stages: $$\sqrt{s} = 350\,\text {GeV} 1.4 . initial stage operation allows study boson production in Higgsstrahlung ( \rightarrow {\mathrm{Z}}...
The Mu3e experiment aims to find or exclude the lepton flavour violating decay $\mu \rightarrow eee$ at branching fractions above $10^{-16}$. A first phase of using an existing beamline Paul Scherrer Institute (PSI) is designed reach a single event sensitivity $2\cdot 10^{-15}$. We present overview all aspects technical design and expected performance phase~I detector. high rate up $10^{8}$ muon decays per second low momenta electrons positrons pose unique set challenges, which we tackle...
Abstract Background Mast cells (MC) are powerful inflammatory immune sentinel that drive numerous allergic, inflammatory, and pruritic disorders when activated. MC‐targeted therapies approved in several disorders, yet many patients have limited benefit suggesting the need for approaches more broadly inhibit MC activity. MCs require KIT receptor its ligand stem cell factor (SCF) differentiation, maturation, survival. Here we describe CDX‐0159, an anti‐KIT monoclonal antibody potently...
Abstract Epidermal growth factor receptor (EGF-R) overexpression is common in a large number of solid tumors and represents negative prognostic indicator. Overexpression EGF-R strongly tumor associated, this tyrosine kinase type considered an attractive target for Ab therapy. In study, we describe the evaluation mAb 2F8, high avidity human (IgG1κ) directed against EGF-R, developed using Ig transgenic mice. 2F8 effectively blocked binding EGF TGF-α to EGF-R. At saturating concentrations,...
A bstract The Compact Linear Collider (CLIC) is a proposed future high-luminosity linear electron-positron collider operating at three energy stages, with nominal centre-of-mass energies $$ \sqrt{s} <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msqrt> <mml:mi>s</mml:mi> </mml:msqrt> </mml:math> = 380 GeV, 1 . 5 TeV, and 3 TeV. Its aim to explore the frontier, providing sensitivity physics beyond Standard Model (BSM) precision measurements of processes an emphasis on Higgs...
The major cold shock protein of Escherichia coli, CS7.4, is produced at a level 13% total synthesis upon temperature shift from 37 to 10 degrees C. transcription its gene (cspA) was found be tightly regulated and induced only low temperature. In addition, the cspA mRNA extremely unstable C, so that CS7.4 production hardly detected when culture shifted 15 C initiation site (+1) identified. vivo footprinting demonstrated region bases -35 -73 protected chemical modification, gel mobility...
Targeting recycling endocytic receptors with specific Abs provides a means for introducing variety of tumor-associated Ags into human dendritic cells (DCs), culminating in their efficient presentation to T cells. We have generated mAb (B11) against the mannose receptor that is rapidly internalized by DCs through receptor-mediated endocytosis. By genetically linking melanoma Ag, pmel17, Ab B11, we obtained fully fusion protein, B11-pmel17. Treatment B11-pmel17 resulted pmel17 context HLA...
The neutralizing antibody response to the protective antigen (PA) component of anthrax toxin elicited by approved vaccines is an accepted correlate for vaccine-mediated protection against anthrax. We reasoned that a human anti-PA monoclonal (MAb) selected on basis superior neutralization activity might provide potent fully MAb (also referred as MDX-1303 or Valortim) was chosen from large panel MAbs generated using transgenic mice immunized with recombinant PA solely in vitro neutralization....
We report on a search for elementary particles with charges much smaller than the electron charge using data sample of proton-proton collisions provided by CERN Large Hadron Collider in 2018, corresponding to an integrated luminosity 37.5 fb$^{-1}$ at center-of-mass energy 13 TeV. A prototype scintillator-based detector is deployed conduct first hadron collider sensitive ${\leq}0.1e$. The existence new masses between 20 and 4700 MeV excluded 95% confidence level $0.006e$ $0.3e$, depending...
ABSTRACT Background Mast cells (MCs) respond to an array of allergens that drive allergic and inflammatory diseases. Stem cell factor (SCF), the ligand for receptor KIT, is required MC survival function. Thymic stromal lymphopoietin (TSLP) alarmin promotes Type 2 inflammation in asthma other We describe CDX‐622, a bispecific antibody (bsAb), targets both SCF TSLP neutralize these distinct cytokines. Methods The bsAb CDX‐622 was developed from novel antagonist monoclonal antibodies (mAbs)...
Beam test results of the radiation tolerance study chemical vapour deposition (CVD) diamond against different particle species and energies is presented. We also present beam on independence signal size incident rate in charged detectors based un-irradiated irradiated poly-crystalline CVD over a range fluxes from 2 kHz/cm2 to 10 MHz/cm2. The pulse height sensors was measured with readout electronics peaking time 6 ns. In addition functionality 3D devices demonstrated tests are shown be...
Abstract CD27, a member of the TNFR superfamily, is constitutively expressed in most T cells and plays crucial roles cell effector functions. The costimulation antitumor activity CD27 agonistic Abs have been well documented mouse models. Clinical testing human IgG1 anti-CD27 Ab, varlilumab (clone 1F5), ongoing cancer patients. In this study, we set out to further understand as an immunomodulatory target address mechanism efficacy using different IgG isotypes 1F5 CD27-transgenic mice....
The AIDA-2020 Trigger Logic Unit (TLU) has been designed to be a flexible and easily configurable unit provide trigger control signals devices employed during test beams, integrating them with the beam telescope. most recent iteration of TLU (v1E) re-designed within project integrate hardware used in facilities. Configuration communication are performed over Ethernet. It can as stand-alone or deployed part EUDAQ2 data acquisition framework, which allows it connect wide range LHC readout...
We report on the expected sensitivity of dedicated scintillator-based detectors at LHC for elementary particles with charges much smaller than electron charge. The dataset provided by a prototype detector is used to characterize performance and provide an accurate background projection. Detector designs, including novel slab configuration, are considered data taking period start in 2022 (Run 3) high luminosity LHC. With Run 3 dataset, existence new masses between 10 MeV 45 GeV could be...