A5101963443- Monoclonal and Polyclonal Antibodies Research
- Drilling and Well Engineering
- Reservoir Engineering and Simulation Methods
- Hydraulic Fracturing and Reservoir Analysis
- CAR-T cell therapy research
- Advanced Biosensing Techniques and Applications
- Immune Cell Function and Interaction
- Protein purification and stability
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Colorectal Cancer Screening and Detection
- Cancer Immunotherapy and Biomarkers
- Global Cancer Incidence and Screening
- HER2/EGFR in Cancer Research
- Nanowire Synthesis and Applications
- Immune cells in cancer
- Cancer Risks and Factors
- Phagocytosis and Immune Regulation
- Pancreatitis Pathology and Treatment
- CNS Lymphoma Diagnosis and Treatment
- Control and Dynamics of Mobile Robots
- Veterinary medicine and infectious diseases
- Cell Adhesion Molecules Research
- Vascular Tumors and Angiosarcomas
- Substance Abuse Treatment and Outcomes
Celldex Therapeutics (United States)
2018-2023
UConn Health
2007-2022
Murphy Oil Corporation (United States)
2002-2021
Gorgias Press (United States)
2008
Joint Genome Institute
2005
University of Tulsa
2002
(tumor protein p53) is the most commonly mutated cancer driver gene, but drugs that target mutant tumor suppressor genes, such as
Bispecific T cell–engaging antibodies capable of specifically killing cancer cells expressing mutant RAS neoantigens were generated.
Abstract Chimeric antigen receptor (CAR) T cells have emerged as a promising class of therapeutic agents, generating remarkable responses in the clinic for subset human cancers. One major challenge precluding wider implementation CAR therapy is paucity tumor-specific antigens. Here, we describe development targeting isocitrate dehydrogenase 2 (IDH2) with R140Q mutation presented on cell surface complex common leukocyte allele, HLA-B*07:02. Engineering hinge domain CAR, well crystal...
The optical phenomenon of surface plasmon resonance (SPR) used by Biacore systems enables the detection and measurement protein-protein interactions in real time, without use labels. In this unit, application technology to measure a interaction is described using an antibody its antigen as example. affinity for determined measuring binding kinetics interaction. protocols are divided into three major steps that required Biacore: (1) preparation, (2) assay development, (3) kinetic analysis.
Population cancer screening rates are around 50% for the general population and even lower in rural areas. This study aimed to explore knowledge, attitudes, behaviours, motivators barriers breast, bowel cervical participation under-screened men women.
Zero-alcohol beverages containing 0.0-0.5% alcohol by volume may offer public health benefits if individuals use them to substitute for alcohol-containing products, thereby reducing use. There are, however, concerns that zero-alcohol encourage adolescents' earlier interest in and increase exposure company branding. As this poses a challenge parents, we studied parents' views on their provision adolescents. We interviewed n=38 parents of 12-17-year-olds used reflexive thematic analysis...
Interleukin-1 receptor-associated kinase (IRAK) 4 mediates host defense against infections. As an active kinase, IRAK4 elicits full spectra of myeloid differentiation primary response protein (MyD) 88-dependent responses, while kinase-inactive induces a subset cytokines and negative regulators whose expression is not regulated by mRNA stability. activity critical for resistance Streptococcus pneumoniae, but its involvement in autoimmunity incompletely understood. In this study, we determined...
Abstract IL-1 receptor-associated kinase (IRAK) 4 is a central enzyme of the TLR pathways. This study tested hypothesis that IRAK4 activity prerequisite for regulating innate immunity during infections with intracellular bacteria. To this end, we analyzed responses macrophages obtained from mice expressing wild-type (WT) or its kinase-inactive K213M mutant (IRAK4KI) upon infection bacteria Listeria monocytogenes Mycobacterium smegmatis. In contrast to robust induction cytokines by...
Endotoxin tolerance protects the host by limiting excessive 'cytokine storm' during sepsis, but compromises ability to counteract infections in septic shock survivors. It reprograms Toll-like receptor (TLR) 4 responses attenuating expression of proinflammatory cytokines without suppressing anti-inflammatory and antimicrobial mediators, mechanisms reprogramming remain unclear. In this study, we demonstrate that induction endotoxin human monocytes, THP-1 MonoMac-6 cells inhibited...
The entry of HIV-1 into permissible cells remains an extremely attractive and underexploited therapeutic intervention point. We have previously demonstrated the ability to extend chemotypes available for optimization in inhibitor class using computational means. Here, we continue this effort, designing testing three novel compounds with inhibit entry. demonstrate that alteration core moiety these inhibitors directly influences potency compounds, despite common proximal distal groups....
Primary cutaneous ganglioneuroma is an extremely rare tumor. We report a case of solitary on the back 75‐year‐old woman.
Immunoglobulin-like transcript 4 (ILT4) is an immunosuppressive molecule predominantly expressed on myeloid cells. Recent studies combining ILT4 suppression with programmed cell death 1 (PD-1)/programmed ligand (PD-L1) blockade have shown promising signs of activity in immune checkpoint inhibitor refractory patients. We theorized that coupling and PD-1/PD-L1 a bispecific antibody (bsAb) may provide greater activating properties than the individual mAbs due to enhanced bridging APCs T To test...
Summary Recently acquired geological, geophysical, and engineering data at the Nash Draw Brushy Canyon Pool revealed that initial reservoir characterization was too simplistic to capture critical features of this complex Delaware formation. A new description provides sufficient detail indicate compartmentalization exists in interval. This is being used identify "sweet spots" for a development drilling program as well optimize management strategies. paper presents recent results an integrated...
Abstract Both PD-1 and ILT4 (LILRB2, CD85d) have well established immunosuppressive effects that enable tumors to evade anti-tumor immunity. Tumor expression of PD-L1 has been associated with poor clinical outcomes in several cancer types. Recently, activation postulated as a resistance mechanism for PD-1/PD-L1 blockade prompting the investigation dual these pathways. Siu, L.L. et al. (2022 Clin Cancer Res 28: 57-70) reported encouraging results initial study combining antagonist mAb MK-4830...
Abstract Members of the TAM family receptor tyrosine kinases (RTKs) play important roles in tumorigenesis and homeostatic regulation immune system. Two closely related ligands, Protein S (PROS1) Growth Arrest Specific 6 (GAS6), bind activate TAMs, with GAS6 activating all TAMs PROS1 MerTK Tyro3. RTKs are aberrantly expressed many types cancer where they may promote survival, metastasis, chemoresistance. These receptors also on innate cells, particularly macrophages dendritic clearance...