A5014240433- Electrolyte and hormonal disorders
- Monoclonal and Polyclonal Antibodies Research
- Proteoglycans and glycosaminoglycans research
- Pregnancy and preeclampsia studies
- Congenital Diaphragmatic Hernia Studies
- Music Therapy and Health
- Immunotherapy and Immune Responses
- Extracellular vesicles in disease
- Birth, Development, and Health
- Plant tissue culture and regeneration
- Bacterial Infections and Vaccines
- Nanoplatforms for cancer theranostics
- Pharmaceutical studies and practices
- Immunodeficiency and Autoimmune Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Cardiac Arrest and Resuscitation
- Advanced Biosensing Techniques and Applications
- Angiogenesis and VEGF in Cancer
- Cytokine Signaling Pathways and Interactions
- Phytochemistry and biological activities of Ficus species
- Vascular Anomalies and Treatments
- Congenital Anomalies and Fetal Surgery
- Drug Transport and Resistance Mechanisms
Indian Statistical Institute
2024
Momenta Pharmaceuticals (United States)
2008-2018
Institute of Post Graduate Medical Education and Research
2015-2018
Post Graduate Institute of Medical Education and Research
2015
Millennium Engineering and Integration (United States)
2004
Albert B. Chandler Hospital
2001
University of Kentucky
1991-2001
Bhabha Atomic Research Centre
2001
The Graduate Center, CUNY
1997
There is an urgent need to determine whether oversulfated chondroitin sulfate (OSCS), a compound contaminating heparin supplies worldwide, the cause of severe anaphylactoid reactions that have occurred after intravenous administration in United States and Germany.Heparin procured from Food Drug Administration, consisting suspect lots associated with clinical events as well control heparin, were screened blinded fashion both for presence OSCS any biologic activity could potentially link...
Heparan sulfate proteoglycans (HSPGs) play a key role in shaping the tumor microenvironment by presenting growth factors, cytokines, and other soluble factors that are critical for host cell recruitment activation, as well promoting progression, metastasis, survival. M402 is rationally engineered, non-cytotoxic heparan (HS) mimetic, designed to inhibit multiple implicated tumor-host interactions, including VEGF, FGF2, SDF-1α, P-selectin, heparanase. A single s.c. dose of effectively...
The intracellular mechanism(s) underlying the upregulation of hepatic Na+/taurocholate cotransporting polypeptide (ntcp) by prolactin (PRL) are unknown. In this report, we demonstrate a time-dependent increase in nuclear translocation phosphorylated liver Stat5 (a member ignal ransducers and ctivators ranscription family) that correlated with suckling-induced increases serum PRL levels. electrophoretic mobility gel shift assays, exhibited specific DNA-binding ability towards...
A series of size-defined low-molecular-weight heparins were generated by regioselective chemical modifications and profiled for their in vitro vivo activities. The compounds displayed reduced anti-coagulant activity, demonstrated varying affinities toward angiogenic growth factors (fibroblast factor-2, vascular endothelial factor stromal cell-derived factor-1α), inhibited the P-selectin/P-selectin glycoprotein ligand-1 interaction and, notably, exhibited anti-tumor efficacy a murine melanoma...
The gastrointestinal tract represents one of the largest body surfaces that is exposed to outside world. It only mucosal surface required simultaneously recognize and defend against pathogens, while allowing nutrients containing foreign antigens be tolerated absorbed. differentiates between these substances through a complex system pattern recognition receptors expressed on intestinal epithelial cells as well underlying immune cells. These actively sample evaluate microbes other particles...
Abstract The aims of this randomized, double‐blind, three‐arm, single‐dose study were to demonstrate pharmacokinetic (PK) equivalence the adalimumab biosimilar M923 (hereafter referred as “M923”) each 2 reference products, and assess M923's safety immunogenicity. Primary PK endpoints maximum observed concentration ( C max ), area under curve (AUC) from time 0 extrapolated infinity (AUC 0‐inf AUC 336 hours 0‐336 ). Secondary included immunogenicity assessments. Healthy subjects randomized...
We have shown that Na+/taurocholate co-transport activity is decreased in pregnancy, but rebounds post partum relative to non-pregnant controls, and can be increased by treatment with ovine prolactin [Ganguly, Hyde Vore (1993) J. Pharmacol. Exp. Ther. 267, 82-87]. To determine the basis for these effects, was determined purified basolateral liver plasma-membrane (bLPM) vesicles compared steady-state mRNA levels encoding Na+/taurocholate-co-transporting polypeptide (Ntcp) pregnant rats (19-20...
An investigation of a series single replacement analogues PrRP-(19-31)-peptide has shown that good functional activity was retained when Phe31 replaced with His(Bzl), Phe(4Cl), Nle, Trp, Cys(Bzl) or Glu(OBzl); Val28 Ile25 Phg; Gly24 D-Ala, L-Ala, Pro Sar; Ser22 Gly and Ala21 Thr MeAla. The results confirm the functionally important residues are located within carboxyl terminal segment, -Ile-Arg-Pro-Val-Gly-Arg-Phe-NH2.
We investigated the transcriptional regulation of Na(+)/taurocholate cotransporting polypeptide gene by PRL, placental lactogen, and GH. In primary hepatocytes, ovine PRL induced a dose-dependent phosphorylation nuclear translocation signal transducers activators transcription-5a -5b, but not -1 or -3, whereas mouse lactogen I rat GH activated -5a, -1. EMSAs, I, increased specific DNA binding transducer activator transcription-5 to its consensus element in both transfected HepG2 cells...
Background: This study was carried out to evaluate the effect of Indian Classical Music (Raga Therapy) on Fentanyl, Vecuronium, Propofol requirements and cortisol levels during cardiopulmonary bypass.Cardiopulmonary bypass is associated with immense stress response high intra operative which detrimental patient involves large doses Vecuronium requirement maintain hemodynamic stability operatively.We evaluated classical music therapy above drugs cardio pulmonary bypass.Methods: After...
Glatopa™ is a generic glatiramer acetate recently approved for the treatment of patients with relapsing forms multiple sclerosis. Gene expression profiling was performed as means to evaluate equivalence Glatopa and Copaxone®. Microarray analysis containing 39,429 unique probes across entire genome in murine acetate--responsive Th2-polarized T cells, test system highly relevant biology acetate. A closely related but nonequivalent glatiramoid molecule used control establish assay sensitivity....
Surgery in a child is one of the most important events its life.Exposure to hospital environment including operating room away from own area comfort, meeting with new peoples and visualising sick people agony creates significant impact on child's mind.Any unfavourable experience this circumstance not only fear towards medical systems for lifetime but also sometimes lead serious psychological consequences like post-traumatic stress disorders.The perioperative period particularly scenario...
We have shown that prolactin (Prl) increases the transhepatic transport of taurocholate (TC) in postpartum rats and following treatment ovariectomized (Ovx) with ovine Prl (oPrl). The present studies were designed to determine if Ovx oPrl (100, 300, or 600 micrograms/day, 7 days iv) 1) Na(+)-TC cotransport basolateral plasma membrane vesicles (bLPM), 2) induces a corresponding increase steady-state levels polypeptide (Ntcp mRNA), 3) oPrl-mediated activity is blocked by cycloheximide, an...
Background: This study was carried out to evaluate the effect of Indian Classical Music (Raga Therapy) on Fentanyl, Vecuronium, Propofol requirements and cortisol levels during cardiopulmonary bypass. Cardiopulmonary bypass is associated with immense stress response high intra operative which detrimental patient involves large doses Vecuronium requirement maintain hemodynamic stability operatively. We evaluated classical music therapy above drugs cardio pulmonary Methods: After obtaining...