A5068697899- Synthetic Aperture Radar (SAR) Applications and Techniques
- Advanced SAR Imaging Techniques
- Advanced Database Systems and Queries
- Pharmacological Effects and Toxicity Studies
- Remote-Sensing Image Classification
- Epilepsy research and treatment
- Semantic Web and Ontologies
- Image and Signal Denoising Methods
- Drug Transport and Resistance Mechanisms
- Logic, Reasoning, and Knowledge
- Neuroscience and Neuropharmacology Research
- Underwater Acoustics Research
- Soil Moisture and Remote Sensing
- Medical Image Segmentation Techniques
- Remote Sensing and Land Use
- Pharmacogenetics and Drug Metabolism
- Bayesian Methods and Mixture Models
- Geophysical Methods and Applications
- Data Management and Algorithms
- Remote Sensing and LiDAR Applications
- Cryospheric studies and observations
- Radar Systems and Signal Processing
- Receptor Mechanisms and Signaling
- Ultrasonics and Acoustic Wave Propagation
- Cell Adhesion Molecules Research
UCB Pharma (Belgium)
2014-2023
John Wiley & Sons (United States)
2023
Hudson Institute
2023
Liechtenstein Institute
2023
Télécom Paris
2009-2020
Laboratoire Traitement et Communication de l’Information
1997-2019
École Nationale Supérieure des Mines de Paris
2019
Université Paris-Saclay
2016-2018
Analyse, Géométrie et Modélisation
2013-2017
University of Florida
2017
The authors propose a two-step algorithm for almost unsupervised detection of linear structures, in particular, main axes road networks, as seen synthetic aperture radar (SAR) images. first step is local and used to extract features from the speckle image, which are treated road-segment candidates. present two line detectors well method fusing information these detectors. In second global step, they identify real roads among segment candidates by defining Markov random field (MRF) on set...
We propose a classification method suitable for high-resolution synthetic aperture radar (SAR) images over urban areas. When processing SAR images, there is strong need statistical models of scattering to take into account multiplicative noise and high dynamics. For instance, the process needs be based on use statistics. Our main contribution choice an accurate model areas its in Markovian algorithm. Clutter becomes non-Gaussian when resolution or area man-made. Many have been proposed fit...
Summary Objective Rapid distribution to the brain is a prerequisite for antiepileptic drugs used treatment of acute seizures. The preclinical studies described here investigated high‐affinity synaptic vesicle glycoprotein 2A ( SV 2A) drug brivara‐cetam BRV ) its rate penetration and onset action. was compared with levetiracetam LEV ). Methods In vitro permeation were performed using Caco‐2 cells. Plasma levels measured over time after single oral dosing audiogenic mice correlated...
11 C-UCB-J is a positron emission tomography (PET) radioligand that has been used in humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as potential density marker. The centrum semiovale (CS) proposed reference region noninvasive quantification of C-UCB-J, due to negligible concentrations SV2A this baboon brain assessed by vitro methods. However, displacement scans with SV2A-specific drug levetiracetam humans, decrease concentration was observed the CS, consistent some degree...
In this paper, we propose a fast and efficient multitemporal despeckling method. The key idea of the proposed approach is use ratio image, provided by between an image temporal mean stack. This easier to denoise than single thanks its improved stationarity. Besides, temporally stable thin structures are well preserved mean. can be divided into three steps: 1) estimation “superimage” averaging possibly spatial denoising; 2) denoising noisy interest “superimage”; 3) computation denoised...
Summary Objective Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro in vivo animal studies suggest faster brain penetration SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human SO time course of LEV at therapeutically relevant doses using the positron emission tomography (PET) tracer 11 C‐UCB‐J ( EP0074 ; NCT02602860 ). Methods Healthy volunteers were recruited into three cohorts. Cohort 1 (n = 4)...
Multitemporal satellite synthetic aperture radar (SAR) images are a useful source of information for geophysicists to monitor changing regions. In this paper, new approach is proposed extract from multitemporal SAR two kinds information: temporal changes (flooded areas, coastline erosion, etc.) and stable spatial features (roads, rivers, etc.). The novelty the detect simultaneously these discontinuities. first step, contrast heterogeneity extracted by "multitemporal" application ratio local...
In radar imaging, it is well known that relative motion or deformations of parts illuminated objects induce additional features in the Doppler frequency spectrum. These are called micro-Doppler effect and appear as sidebands around central frequency. They can provide valuable information about structure moving may be used for identification purposes. Previous papers have mostly focused on 1D analysis. The authors propose to emphasise analysis such 'non-stationary targets' using a 2D imaging...
A new and fast unsupervised technique for segmentation of high-resolution synthetic aperture radar (SAR) images into homogeneous regions is proposed. This based on Fisher probability density functions (pdfs) the intensity fluctuations an image model that consists a patchwork with polygonal boundaries. The obtained by minimizing stochastic complexity image. Different strategies pdf parameter estimation are analyzed, robust Finally, relevance proposed approach demonstrated SAR images.
Brivaracetam (BRV) is a high-affinity synaptic vesicle protein 2A ligand developed for the treatment of uncontrolled partial-onset seizures. The present phase I, open-label, two-way crossover study was designed to assess effect rifampin on pharmacokinetics BRV and its hydroxy (BRV-OH), acid (BRV-AC), (BRV-OHAC) metabolites. Twenty-six healthy subjects received (150-mg single oral dose) either alone or following 5 days 600 mg/day. metabolites were examined their plasma profiles urinary...
This paper discusses change detection in SAR time-series. First, several statistical properties of the coefficient variation highlight its pertinence for detection. Subsequently, criteria are proposed. The is suggested to detect any kind change. Furthermore, that based on ratios coefficients variations proposed long events, such as construction test sites, or point-event, vehicles. These methods first evaluated theoretical simulations determine scenarios where they can deliver best results....