A5011648052- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Lanthanide and Transition Metal Complexes
- Glioma Diagnosis and Treatment
- Neuroscience and Neuropharmacology Research
- Functional Brain Connectivity Studies
- S100 Proteins and Annexins
- Epilepsy research and treatment
- Tryptophan and brain disorders
- Pharmacological Effects and Toxicity Studies
- Radiation Therapy and Dosimetry
- Inflammatory mediators and NSAID effects
- Neonatal and fetal brain pathology
- Radioactive Decay and Measurement Techniques
- Neuroblastoma Research and Treatments
- Particle accelerators and beam dynamics
- Reproductive tract infections research
- Antimicrobial Peptides and Activities
- Advanced Drug Delivery Systems
- PARP inhibition in cancer therapy
- Health, Environment, Cognitive Aging
- Boron Compounds in Chemistry
Columbia University Irving Medical Center
2021-2024
Yale University
2017-2024
Columbia University
2024
Yale Cancer Center
2018-2022
University of New Haven
2018
Stony Brook University
2017
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2016
11 C-UCB-J is a positron emission tomography (PET) radioligand that has been used in humans for synaptic vesicle glycoprotein 2A (SV2A) imaging and as potential density marker. The centrum semiovale (CS) proposed reference region noninvasive quantification of C-UCB-J, due to negligible concentrations SV2A this baboon brain assessed by vitro methods. However, displacement scans with SV2A-specific drug levetiracetam humans, decrease concentration was observed the CS, consistent some degree...
Abstract INTRODUCTION Evidence suggests microglial activation precedes regional tau and neurodegeneration in Alzheimer's disease (AD). We characterized microglia with translocator protein (TSPO) positron emission tomography (PET) within an AD progression model where global amyloid beta (Aβ) local neurodegeneration, resulting cognitive impairment. METHODS Florbetaben, PBR28, MK‐6240 PET, T1 magnetic resonance imaging, measures were performed 19 cognitively unimpaired older adults 22 patients...
Summary Objective Brivaracetam (BRV) and levetiracetam (LEV) are antiepileptic drugs that bind synaptic vesicle glycoprotein 2A (SV2A). In vitro in vivo animal studies suggest faster brain penetration SV2A occupancy (SO) after dosing with BRV than LEV. We evaluated human SO time course of LEV at therapeutically relevant doses using the positron emission tomography (PET) tracer 11 C‐UCB‐J ( EP0074 ; NCT02602860 ). Methods Healthy volunteers were recruited into three cohorts. Cohort 1 (n = 4)...
The morbidity associated with pediatric medulloblastoma, in particular patients who develop leptomeningeal metastases, remains high the absence of effective therapies. Administration substances directly into cerebrospinal fluid (CSF) is one approach to circumvent blood-brain barrier and focus delivery drugs site tumor. However, rates CSF turnover prevent adequate drug accumulation lead rapid systemic clearance toxicity. Here, we show that PLA-HPG nanoparticles, made a single-emulsion,...
Abstract Purpose Neuronal damage and synapse loss in the spinal cord (SC) have been implicated injury (SCI) neurodegenerative disorders such as Amyotrophic Lateral Sclerosis (ALS). Current standards of diagnosis for SCI include CT or MRI imaging to evaluate severity. The current study explores use PET with [ 11 C]UCB-J, which targets synaptic vesicle protein 2A (SV2A), human cord, a way visualize density integrity vivo. Results First, simulations baseline blocking C]UCB-J HRRT scans were...
Abstract Long‐lasting vaginal dosage forms could improve the therapeutic efficacy of microbicides, but achieving long‐term delivery to canal has been a significant challenge. To advance understanding retention and biodistribution, we describe method noninvasive imaging with 89 Zr‐labeled bioadhesive nanoparticles (BNPs) in non‐human primates. We additionally examined safety repeated BNP application. BNPs administered vaginally cynomolgus monkeys were still detected after 24 h (1.7%...
Abstract Objectives Microglia monitor and respond to the brain ’ s microenvironment maintain homeostasis. However, in Alzheimer disease related dementias (ADRD), microglia may contribute pathology. We hypothesized that AD-related inflammatory changes, measured with TSPO PET, would be locally associated amyloid, tau, neurodegeneration, influence key pathways among them. Methods Participants (21 controls, 25 ADRD) from Longitudinal Imaging of Microglial Activation Different Clinical Variants...
Abstract Background Noninvasive yet accurate PET quantification methods are crucial for safe meaningful studies. [11C]ER176 is a radioligand that images neuroinflammation via the 18‐kDa translocator protein (TSPO), which upregulated in activated microglia and has previously been target Alzheimer’s disease research. Currently, gold‐standard method quantifying ER176 kinetic modeling of dynamic data using arterial input function (AIF), invasive expensive. The current study explores...
Abstract Background Adults with Down syndrome (DS) overproduce the amyloid precursor protein and nearly all evidence clinical symptoms of Alzheimer’s Disease (AD) dementia in later life. Sleep disordered breathing, specifically, obstructive sleep apnea (OSA), is common adults DS. OSA has been associated risk AD without DS, disturbances may have a bidirectional relationship pathology. We hypothesized that greater tau burden subsequent breathing time‐lagged design. Methods Eighty young DS...
Abstract Background Moderate alcohol use may provide later life cognitive benefits compared to heavy use. However, results have been mixed, with reports of both increased and decreased gray white matter volumes moderate drinking. Additionally, on brain health differ by sex race/ethnicity. Understanding the association between drinking in a representative, community‐based study will insight into reported benefits. We investigated relationship total volume (TBV) hyperintensities (WMH) diverse...
Abstract Background Moderate alcohol use may provide later life cognitive benefits compared to heavy use. However, results have been mixed, with reports of both increased and decreased gray white matter volumes moderate drinking. Additionally, on brain health differ by sex race/ethnicity. Understanding the association between drinking in a representative, community‐based study will insight into reported benefits. We investigated relationship total volume (TBV) hyperintensities (WMH) diverse...
Abstract Background Noninvasive yet accurate PET quantification methods are crucial for safe meaningful studies. [ 11 C]ER176 is a radioligand that images neuroinflammation via the 18‐kDa translocator protein (TSPO), which upregulated in activated microglia and has previously been target Alzheimer’s disease research. Currently, gold‐standard method quantifying ER176 kinetic modeling of dynamic data using arterial input function (AIF), invasive expensive. The current study explores...
Abstract Background Glial activation may precede regional tau progression through Braak stages in Alzheimer’s Disease (AD)[1]. However, the role of glial activity temporal AD is not well characterized. Method Nineteen controls and 22 patients with clinical diagnosis MCI or underwent [ 18 F]florbetaben, F]MK‐6240, 11 C]PBR28 PET to measure β‐amyloid, tau, TSPO (a biomarker). Standard uptake value ratios corrected gray matter volume (%GM) were calculated from prefrontal, temporal, parietal...