A5100409440- CAR-T cell therapy research
- Nitric Oxide and Endothelin Effects
- Monoclonal and Polyclonal Antibodies Research
- Chronic Lymphocytic Leukemia Research
- Pulmonary Hypertension Research and Treatments
- Immune Cell Function and Interaction
- Lanthanide and Transition Metal Complexes
- Traumatic Brain Injury and Neurovascular Disturbances
- Photosynthetic Processes and Mechanisms
- Optical Imaging and Spectroscopy Techniques
- Cardiac Ischemia and Reperfusion
- MRI in cancer diagnosis
- Nanowire Synthesis and Applications
- Photoreceptor and optogenetics research
- Pluripotent Stem Cells Research
- T-cell and B-cell Immunology
- Tissue Engineering and Regenerative Medicine
- Eicosanoids and Hypertension Pharmacology
- Virus-based gene therapy research
- Advanced MRI Techniques and Applications
- Neuroscience of respiration and sleep
- Cancer Immunotherapy and Biomarkers
- Renin-Angiotensin System Studies
- Nanoparticle-Based Drug Delivery
- Cellular transport and secretion
Beijing Biocytogen (China)
2023
Sidney Kimmel Comprehensive Cancer Center
2021
Johns Hopkins University
1997-2021
Howard Hughes Medical Institute
2013-2021
National Institutes for Food and Drug Control
2019
Capital Medical University
2018
Guangzhou Institutes of Biomedicine and Health
2018
Chinese Academy of Sciences
2018
State Key Laboratory of Respiratory Disease
2018
Beijing Tian Tan Hospital
2018
(tumor protein p53) is the most commonly mutated cancer driver gene, but drugs that target mutant tumor suppressor genes, such as
Bispecific T cell–engaging antibodies capable of specifically killing cancer cells expressing mutant RAS neoantigens were generated.
1. The aim of the present study was to determine cellular mechanims and potential mediators involved in hypoxic dilatation porcine small coronary arteries. 2. Small arteries were isolated from a branch left anterior descending artery hearts, cannulated with glass micropipettes studied perfusion myograph system. At transmural pressure 40 mmHg, had an internal diameter 167.8 +/- 6.6 microns (n = 37). 3. In contracted acetylcholine (ACh), hypoxia (0% O2, 30 min) caused (86.9 6.7% relaxation, n...
Treatment with chimeric antigen receptor (CAR)-modified T cells targeting CD19 has proved successful in patients relapsed/refractory B cell malignancies. However, long-term follow-up indicates that remission a substantial proportion of is not sustainable. Most experience recurrence have tumors and lost the CAR-T cells. To maintain activity cells, Raji-B-NDG mice were treated sequentially CAR-T-19 homologous expressing human to promote expansion Sequential treatment followed by Raji tumor led...
Summary Recently, bi‐functional molecules that can redirect immune effectors to tumour cells have emerged as potentially robust mediators of regression in clinical trials. Two modalities particular, bi‐specific antibodies for T‐cell redirection and activation (BiTe) immune‐mobilizing monoclonal receptors against cancer (Imm TAC ), are being evaluated efficacy studies ‘off‐the‐shelf’ reagents. Optimal therapy will require an understanding means address regulatory mechanisms limiting efficacy....
In isolated porcine pulmonary arterioles with endothelium, intraluminal diameter measured at a transmural pressure of 20 mmHg decreased spontaneously from 233 ± 11 to 171 12 μm in 135 min. This intrinsic constriction was not prevented by indomethacin, tetraethylammonium, or superoxide dismutase. Indomethacin plus N G -nitro-l-arginine methyl ester caused initial and BQ-123 BQ-788 dilation, but these treatments did prevent subsequent progressive constriction. endothelium exposed calcium-free...
<h3>Background</h3> Natural killer (NK) cells and T are important therapeutic populations that can target eliminate cancer cells. Although human NK/T cell be reconstituted in immunodeficient mice to test novel NK and/or modulators, the time window for experimentation is often limited due GvHD (graft-versus-host disease) complications. Moreover, development maturation such models lack of IL15. Previously, we disrupted murine B2m allele (B-NDG) fused FcRn coding region modified ensure normal...
Background Maintenance of normal cerebral oxygen saturation and metabolism is an essential element in perioperative anesthetic management. Several methods have been applied the period to monitor order timely detect ischemia, hypoxia, abnormal perfusion brain. Objective To review three forcerebral oxygenation monitoring provide technical information for application. Content Three procedures commonly used neurosurgery, cardiovascular surgery, ICU achieve surveillance levels. They...
Msx1 is a homeobox-containing transcription repressor that has been demonstrated to play an important role in cellular generation and regeneration processes. Our group, as well one other, ectopic expression of msx1 murine multinucleated myotubes could lead de-differentiation into mononucleated cells are capable proliferation which possess properties pluripotent stem cells. Previously, we have msx1-dedifferentiated (MDCs) differed from myoblasts by exhibiting reduction the levels myogenic...