A5021327213- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Immune Cell Function and Interaction
- Cellular Mechanics and Interactions
- RNA Research and Splicing
- TGF-β signaling in diseases
- Immunotherapy and Immune Responses
- Plant Pathogens and Fungal Diseases
- Nuclear Structure and Function
- Oral and Maxillofacial Pathology
- Microtubule and mitosis dynamics
- Cancer Cells and Metastasis
- Plant-Microbe Interactions and Immunity
- Fibroblast Growth Factor Research
- Metabolism and Genetic Disorders
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Amino Acid Enzymes and Metabolism
- Insurance, Mortality, Demography, Risk Management
- Lung Cancer Research Studies
- Proteoglycans and glycosaminoglycans research
- Trace Elements in Health
- Kruppel-like factors research
- RNA modifications and cancer
- RNA and protein synthesis mechanisms
- Ferroptosis and cancer prognosis
Hubei Academy of Agricultural Sciences
2023-2024
Institute of Plant Protection
2023-2024
Southern Medical University
2024
Nanfang Hospital
2024
Ministry of Agriculture and Rural Affairs
2023
University of Toronto
2015-2022
Chinese PLA General Hospital
2022
Guangzhou Institutes of Biomedicine and Health
2017-2021
Chinese Academy of Sciences
2017-2021
State Key Laboratory of Respiratory Disease
2018-2021
Bone morphogenetic protein 2 (BMP-2) has been reported to facilitate epithelial-to-mesenchymal transition (EMT) and bone metastasis in breast cancer xenograft models. To investigate the role of BMP-2 development stem cells (BCSCs), further elucidate mechanisms underlying its influence on metastasis, we conducted a comprehensive molecular study using cell lines clinical samples. Our results showed that downregulation Rb by was associated with ubiquitin-mediated degradation activated...
Abstract T-cell receptor (TCR) engineered therapy has recently emerged as a promising adoptive immunotherapy approach for tumor treatment, yet hindered by immune evasion resulting in poor therapeutic efficacy. The introduction of ferroptosis-targeted inducers offers potential solution, they empower T cells to induce ferroptosis and exert influence over the microenvironment. Atovaquone (ATO) stands prospective pharmaceutical candidate with target ferroptosis, effectively provoking an...
Objectives: This study aimed to explore the distribution features and trends of dementia mortality in China from 2011 2020 make a prediction for next decade. Methods: Mortality-relevant data were gathered Chinese Center Disease Control Prevention's Surveillance Points system. Joinpoint regression was applied evaluate trends. Results: Crude Mortality Rate (CMR) AD other dementias increased 3.7 per 100,000 6.2 2011-2020, with an Average Annual Percent Change (AAPC) 5.3% (95% CI 4.4%-6.3%)....
During cytokinesis, the actin cytoskeleton is partitioned into two spatially distinct isoform specific networks: a β-actin network that generates equatorial contractile ring, and γ-actin localizes to cell cortex. Here we demonstrate opposing regulation of β- networks required for successful cytokinesis. While activation formin DIAPH3 at cytokinetic furrow underlies filament production, show specifically depleted poles through localized deactivation DIAPH1. anaphase, CLIP170 delivered by...
Barnyardgrass (Echinochloa crus-galli (L.) Beauv.) is one of the most troublesome weeds in transplanted and direct-seeded rice worldwide. To develop a strategy for biocontrol barnyardgrass, fungal isolates were recovered from barnyardgrass plants that exhibited signs necrosis wilt. An isolate B-48 with high level pathogenicity to was identified after tests. From cultural DNA sequence data, this strain as Colletotrichum echinochloae. The inoculation plant C. echinochloae caused significant...
Bone morphogenetic proteins (BMPs) are involved in diverse biological processes, including cell proliferation, differentiation and apoptosis. Results from the MTT assay revealed that BMP-2 significantly inhibited proliferation of MDA-MB‑231 MCF-7 breast cancer cells. The flow cytometric analysis demonstrated caused G1 arrest promoted An increase p21 cleaved caspase-3 two lines was detected by western blot analysis, which may be responsible for suppression BMP-2. protected MDA-MB-231 cells...
We have developed a strong inhibitor (S252W mutant soluble ectodomain of fibroblast growth factor recptor-2 IIIc, msFGFR2) that binds FGFs strongly and blocks the activation FGFRs. In vitro, msFGFR2 could inhibit promoting effect transforming (TGF)-β1 on proliferation primary lung fibroblasts. vivo, alleviated fibrosis through inhibiting expression α-smooth muscle actin (SMA) collagen deposit. Western blotting right tissues immunohistochemical assay, we found level p-FGFRs, p-mitogen...
Cleavage of one cell into two is the most dramatic event in life a cell. Plasma membrane fission occurs within narrow intercellular bridge (ICB) between daughter cells, but mechanisms underlying ICB formation and maturation are poorly understood. Here we identify CIN85 as an assembly factor demonstrate its requirement for robust timely cytokinesis. interacts directly with N-terminal region anillin SEPT9 thereby facilitates SEPT9-containing filament localization to plasma ICB. In contrast,...
The actin cytoskeleton is a dynamic array of filaments that undergoes rapid remodeling to drive many cellular processes. An essential feature filament the spatio-temporal regulation nucleation. One family nucleators, Diaphanous-related formins, activated by binding small G-proteins such as RhoA. However, RhoA only partially activates suggesting additional factors are required fully activate formin. Here we identify one factor, IQ motif containing GTPase activating protein-1 (IQGAP1), which...
Summary Recently, bi‐functional molecules that can redirect immune effectors to tumour cells have emerged as potentially robust mediators of regression in clinical trials. Two modalities particular, bi‐specific antibodies for T‐cell redirection and activation (BiTe) immune‐mobilizing monoclonal receptors against cancer (Imm TAC ), are being evaluated efficacy studies ‘off‐the‐shelf’ reagents. Optimal therapy will require an understanding means address regulatory mechanisms limiting efficacy....
Abstract A fundamental understanding of cancer-specific antigens is crucial for successful T-cell immunotherapy. Sarcoma antigen 1 (SAGE1) a cancer/testis that has not yet been verified immunotherapy applications. Here, we examined SAGE1 RNA expression and carried out IHC analyses, revealing expressed in 50% non–small cell lung-cancer samples (n = 40). To verify the immunogenicity SAGE1, discovered novel HLA-A*24:02 (HLA-A24)–restricted epitope (SAGE1597–606, VFSTAPPAFI) using mass...
Summary The affinity of T‐cell receptor ( TCR ) determines the efficacy ‐based immunotherapy. By using human leucocyte antigen HLA )‐A*02 transgenic mice, a was generated previously specific for tumour testis peptide MAGE ‐A3 112–120 KVAELVHFL ‐A*02 complex. We developed an approach to humanize murine by replacing mouse framework with sequences folding optimized variable domains retaining binding affinity. resultant humanized exhibited higher and conferred better anti‐tumour activity than...
ABSTRACT We present two whole-genome sequences of Colletotrichum strains which were isolated from Eleusine indica and Echinochloa crus-galli using Nanopore Illumina technologies, as part screening for potential mycoherbicide. The genome will provide important genetic information be useful further research into secondary metabolites .
Orthostatic tremor (OT) is a type of postural the lower extremities that has not been described in either phenylketonuria (PKU) or hyperphenylalaninemia (HPA). Because little known about clinical features and therapeutic responses OT mild HPA, we describe HPA patient who presented with as an initial symptom.A 22-year-old male was admitted for bilateral leg while standing, symptom onset eight months prior. One month before admission, disappeared left but persisted right leg. Electromyography...