A5016526103- Viral Infections and Vectors
- Mosquito-borne diseases and control
- Viral Infections and Outbreaks Research
- Bacillus and Francisella bacterial research
- Fire effects on ecosystems
- Poxvirus research and outbreaks
- Infection Control and Ventilation
- Vector-Borne Animal Diseases
- Herpesvirus Infections and Treatments
- COVID-19 epidemiological studies
- Vector-borne infectious diseases
- COVID-19 and healthcare impacts
- SARS-CoV-2 detection and testing
- Insect symbiosis and bacterial influences
- Malaria Research and Control
- SARS-CoV-2 and COVID-19 Research
- Virology and Viral Diseases
- Plant Virus Research Studies
- Insect and Pesticide Research
- Rabies epidemiology and control
- Infection Control in Healthcare
- COVID-19 and Mental Health
- COVID-19 Clinical Research Studies
- Occupational Health and Safety Research
- Burn Injury Management and Outcomes
UK Health Security Agency
2022-2025
Health Protection Research Unit in Emerging and Zoonotic Infections at University of Liverpool
2025
University of Liverpool
2025
European Society of Clinical Microbiology and Infectious Diseases
2024
The Pirbright Institute
2019-2023
Edinburgh Genomics
2023
University of Edinburgh
2023
University of York
2023
Public Health England
2013-2022
University of California, San Diego
2016
Characterizing the Zika virus antibody response Given public health emergency that poses, scientists are seeking to understand Zika-specific immune response. Stettler et al. analyzed 119 monoclonal antibodies isolated from four donors were infected with during present epidemic, including two individuals had previously been dengue virus, another member of flavivirus family. Neutralizing primarily recognized envelope protein domain III (EDIII) or quaternary epitopes on intact and an...
Analysis of 179 new Ebola virus sequences from patient samples collected in Guinea between March 2014 and January 2015 shows how different lineages evolved spread West Africa. Miles Carroll colleagues report describe the genetic evolution circulating Africa, based on 2015. Their analysis Africa Sierra Leone, Liberia. is currently witnessing most extensive (EBOV) outbreak so far recorded1,2,3. Until now, there have been 27,013 reported cases 11,134 deaths. The origin thought to a zoonotic...
Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond Africa and into Pacific South American regions. Despite first being detected in 1947, very little information known about the virus, its been associated with increases Guillain-Barre syndrome microcephaly. There are currently no vaccines or antivirals against ZIKV infection. Progress assessing interventions will require development of animal models to test efficacies; however, there only limited reports on vivo...
Crimean-Congo hemorrhagic fever (CCHF) is a virulent tick-borne disease with case fatality rate ranging from 10-50% for transmission, and up to 80% nosocomial transmission. Human cases have been reported in over 30 countries across Europe, Asia, Africa. It appears be spreading new areas several reporting their first human of CCHF within the past 10 years. We report novel real-time RT-PCR assay designed amplify conserved region virus S segment. capable detecting strains all 7 groups CCHF,...
Zika virus RNA has been detected in semen collected several months after onset of symptoms infection. Given the potential for sexual transmission and serious fetal abnormalities resulting from infection during pregnancy, information regarding persistence is critical advancing our understanding risks. We tested serial samples symptomatic male patients United Kingdom who had a diagnosis imported Among initial 23 patients, was at high levels 13 (56.5%) not 9 (39.1%); detection indeterminate 1...
An imported case of monkeypox was diagnosed in December 2019 a traveller returning from Nigeria to the UK. Subsequently, environmental sampling performed at two adjoining single-room residences occupied by patient and their sibling. Monkeypox virus DNA identified multiple locations throughout both properties, isolated several samples 3 days after last these locations. Positive were following use vacuum surface techniques; methodologies allowed for analysis potentially contaminated porous...
Following a suspected case of hantavirus in patientsuffering from acute kidney injury, rodents fromthe patient’s property Yorkshire and the Humber,United Kingdom (UK) were screened for hantaviruses.Hantavirus RNA was detected via RT-PCR two Rattusnorvegicus. Complete sequencing phylogeneticanalysis established virus as Seoul hantavirus,which we have provisionally designated strainHumber. This is first isolated wildrodents UK confirms presence pathogenicSeoul Europe.
Zika virus (ZIKV) falls into two lineages: African (ZIKVAF) and Asian (ZIKVAS). These lineages have not been tested comprehensively in parallel for disease progression using an animal model system. Here, the established type-I interferon receptor knockout (A129) mouse model, it is first demonstrated that ZIKVAF causes lethal infection, with different kinetics of manifestations according to challenge dose. Animals challenged a low dose 10 plaque-forming units (pfu) developed more neurological...
Abstract Zika virus (ZIKV) is a mosquito-borne pathogen which has recently spread beyond Africa and into Pacific South American regions. Despite first being detected in 1947, very little information known about the its been associated with increases Guillain-Barre syndrome microcephaly. There are currently no vaccines or antivirals against ZIKV infection. Progress assessing interventions will require development of animal models to test efficacies; however, there only limited reports on vivo...
The 2013-16 Ebola virus disease epidemic in west Africa caused international alarm due to its rapid and extensive spread resulting a significant death toll social unrest within the affected region. large number of cases provided an opportunity study long-term kinetics Zaire ebolavirus-specific immune response survivors addition known contacts those infected with virus.
Crimean-Congo hemorrhagic fever (CCHF) is a serious disease with high fatality rate reported in many countries. The first case of CCHF Oman was detected 1995 and serosurveys have suggested widespread infection humans livestock throughout the country.Cases to Ministry Health (MoH) between 2017 were retrospectively reviewed. Diagnosis confirmed by serology and/or molecular tests Oman. Stored RNA from recent cases studied sequencing complete open reading frame (ORF) viral S segment at Public...
Abstract Background A SARS-CoV-2 outbreak with an attack rate of 14.3% was reported at a plastics manufacturing plant in England. Methods Between 23 rd March and 13 th May 2021, the COVID-OUT team undertook comprehensive investigation, including environmental assessment, surface sampling, molecular serological testing, detailed questionnaires, to identify potential transmission routes, workplace- worker-related risk factors. Results While ventilation, indicated using real-time CO 2 proxy...
Background. A unit of the European Mobile Laboratory (EMLab) consortium was deployed to Ebola virus disease (EVD) treatment in Guéckédou, Guinea, from March 2014 through 2015. Methods. The diagnosed EVD and malaria, using RealStar Filovirus Screen reverse transcription–polymerase chain reaction (RT-PCR) kit a malaria rapid diagnostic test, respectively. Results. cleaned EMLab database comprised 4719 samples 2741 cases suspected Guinea. 1231 2178 hospitalized patients (57%) 281 563 who died...
Background Despite several studies on the seroprevalence of antibodies against Crimean-Congo Haemorrhagic Fever virus (CCHFV) from humans and cattle in Nigeria, detailed investigation looking at IgG IgM have not been reported. Additionally, there no confirmed cases human CCHFV infection reported Nigeria. Principal Findings Samples sera (n = 1189) collected four Local Government Areas Borno State (Askira/Uba, Damboa, Jere Maiduguri) were assessed for presence antibodies. The positivity rates...
Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria June 2014. The patient developed moderately severe disease including fever, headaches and petechial rash. CCHF following identification of virus (CCHFV) RNA serum sample taken five days after symptom onset. Sequence analysis the CCHFV genome showed that clusters within Europe 1 clade, which includes viruses eastern Europe.
Crimean-Congo haemorrhagic fever (CCHF) is a pathogenic and often fatal arboviral disease with distribution spanning large areas of Africa, Europe Asia. The causative agent negative-sense single-stranded RNA virus classified within the Nairovirus genus Bunyaviridae family. Cases CCHF have been officially recorded in Kazakhstan since was first reported modern medicine. Serological surveillance human animal populations provide evidence that perpetually circulating local enzoonotic cycle...
Multiple viruses, including pathogenic bacteriophages, and even plant cause a phenomenon termed superinfection exclusion whereby currently infected cell is resistant to secondary infection by the same or closely related virus. In alphaviruses, this process thought be mediated, at least in part, viral protease (nsP2) which responsible for processing nonstructural polyproteins (P123 P1234) into individual proteins (nsP1-nsP4), forming replication complex. Taking synthetic biology approach, we...
A patient with fever, and haemorrhagic symptoms was admitted to a hospital in Glasgow on 2 October 2012. Since he had returned from Afghanistan, serum samples were sent for diagnosis at the Rare Imported Pathogens Laboratory, where real-time reverse transcriptase-PCR of Crimean – Congo fever made within 3 hrs after receipt sample. Hereafter transferred high-security infectious diseases unit London but died 6 October.