A5062735845- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Hemoglobinopathies and Related Disorders
- Antibiotic Use and Resistance
- Malaria Research and Control
- COVID-19 epidemiological studies
- Antibiotic Resistance in Bacteria
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Iron Metabolism and Disorders
- Lipoproteins and Cardiovascular Health
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Emergency and Acute Care Studies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Intramuscular injections and effects
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- HIV, Drug Use, Sexual Risk
- Urinary Tract Infections Management
- Healthcare Systems and Challenges
- COVID-19 Pandemic Impacts
- Mosquito-borne diseases and control
- Primary Care and Health Outcomes
- Streptococcal Infections and Treatments
UK Health Security Agency
2022-2025
Public Health England
2021-2023
University of Cambridge
2021
University of California, Davis
2019
Vector Oncology (United States)
2019
In response to high levels of demand for primary medical services in England, characterized by longer appointment waiting times and delayed referrals, the Government developed its National Health Service (NHS) Primary Care Recovery Plan. A key component plan is Pharmacy First (PF), which involves participating community pharmacies supplying prescription-only medicine after consultation with a pharmacist seven common conditions: earache, uncomplicated urinary tract infections women, sore...
Abstract Background In 2019, the UKHSA established an antimicrobial resistance (AMR) health inequalities (HI) workstream, with one aim of workstream being to improve AMR and consumption (AMC) surveillance understand burden trends AMC for Core20PLUS populations. also published its Health Equity Strategy in 2023. Objectives To highlight changes national reporting bloodstream infections (BSI), resistant BSIs by HI factors summarize data on included within 2023–24 English Surveillance Programme...
Abstract Background A SARS-CoV-2 outbreak with an attack rate of 14.3% was reported at a plastics manufacturing plant in England. Methods Between 23 rd March and 13 th May 2021, the COVID-OUT team undertook comprehensive investigation, including environmental assessment, surface sampling, molecular serological testing, detailed questionnaires, to identify potential transmission routes, workplace- worker-related risk factors. Results While ventilation, indicated using real-time CO 2 proxy...
Workplace-related outbreaks of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continue to occur globally. The manufacturing sector presents a particular concern for outbreaks, and better understanding transmission risks are needed. Between 9 March 24 April 2021, the COVID-19 (coronavirus disease 2019) Outbreak Investigation Understand Transmission (COVID-OUT) study undertook comprehensive investigation SARS-CoV-2 outbreak at an automotive site in England. had total 266 workers,...
An outbreak of SARS-CoV-2 (1 March to 10 May 2021) with an attack rate 26.5% among approximately 1150 workers at a storage and distribution centre in England prompted multidisciplinary investigation (5 6 August 2021), the aim better understanding worker- workplace-related risk factors for viral transmission warehousing sector. Overall, environmental (e.g., ventilation, humidity temperature) were assessed be appropriate facility. Nevertheless, 39 (51.3%) surface samples from across site...
Background The causal relevance of elevated blood pressure for several cardiovascular diseases (CVDs) is uncertain, as the population impact lowering. This study systematically assesses evidence causality various CVDs in a 2-sample Mendelian randomization framework, and estimates potential reduction prevalence these attributable to long-term shifts distribution systolic (SBP). Methods Results We investigated associations genetically predicted SBP by 256 genetic variants with 21 UK Biobank,...
Insecticide resistance in Anopheles coluzzii mosquitoes has become widespread throughout West Africa including Burkina Faso. The insecticide allele (kdr or L1014F) is a prime indicator that highly correlated with phenotypic Africa. Studies from Benin, Ghana and Mali have suggested the source of L1014F introgression 2L divergence island via interspecific hybridization gambiae. goal this study was to characterize local mosquito populations Nouna Department, Faso respect to: (i) extent between...
<ns3:p>Preventing SARS-CoV-2 transmission and protecting people from COVID-19 is the most significant public health challenge faced in recent years. outbreaks are occurring workplaces evidence needed to support effective strategies prevent control these outbreaks. Investigations into routinely undertaken by bodies regulators United Kingdom (UK); however, such investigations typically disparate nature with a lack of consistency across all investigations, preventing meaningful analysis data...
Introduction. Panton-Valentine leucocidin (PVL) toxin is a potential determinant of virulence associated with S. aureus infection.Gap Statement. The contribution PVL to pathogenicity remains unclear.Aim. To compare clinical outcomes in hospitalized patients PVL-positive and PVL-negative community-acquired (CA) bacteraemia.Methods. Three national datasets were combined provide mortality data for CA blood culture isolates sent the UK reference laboratory testing, August 2018 2021....
Estimates of inappropriate prescribing can highlight key target areas for antimicrobial stewardship (AMS) and inform national targets.To (1) define (2) produce estimates antibiotic levels within acute hospital trusts in England.The 2016 Healthcare-Associated Infections (HAI), Antimicrobial Use (AMU) AMS point prevalence survey (PPS) was used to derive prescribing, focusing on the four most reported community-acquired indications (CAIs) PPS surgical prophylaxis. Definitions appropriate...
To determine whether MDR occurs more frequently in nitrofurantoin-resistant Escherichia coli urinary isolates England, compared with nitrofurantoin-susceptible isolates.Using routine E. urine isolate antibiotic susceptibility laboratory surveillance data for 2015-19 inclusive, the percentage of or XDR phenotype was estimated and laboratory-reported tract samples by region, patient sex age group.Resistance to nitrofurantoin among decreased slightly year on from 2.9% 2015 2.3% 2019. Among UTIs...
The English surveillance programme for antimicrobial utilisation and resistance (ESPAUR) (AMR) chapter reports on bacterial, viral, fungal AMR trends between 2017 2021 in England. A 10.8% increase patient episodes of bacteraemia or fungaemia was observed, the estimated burden decreased by 4.2%. Individuals with an antimicrobial-resistant strain (resistant to ≥1 key burden-defined antibiotics) had a higher crude case fatality rate (18.1%) compared those susceptible (16.3%). effect deprivation...
COVID-19 (coronavirus disease 2019) outbreaks in workplace settings have been investigated to understand how transmission occurred. However, there is limited data looking at conference England, particularly where an outbreak did not occur. The aim of this work was investigate infection risk factors and control measures a large conference, with known case but no reported onward inform prevention future respiratory infections conferences similar settings. This cross-sectional study part wider...
Abstract Background The causal relevance of elevated blood pressure for several cardiovascular diseases is uncertain, as the population impact lowering on risk more broadly. This study systematically assesses evidence causality various in a two-sample Mendelian randomization framework, and estimates potential reduction prevalence these attributable to long-term shifts distribution systolic (SBP). Methods Results We investigated associations genetically-predicted SBP predicted by 256 genetic...