A5038288718- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Medication Adherence and Compliance
- Nausea and vomiting management
- Pharmaceutical Economics and Policy
- Anesthesia and Pain Management
- Pharmaceutical studies and practices
- Frailty in Older Adults
- Geriatric Care and Nursing Homes
- Anesthesia and Sedative Agents
- Primary Care and Health Outcomes
- Healthcare Policy and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Mental Health and Patient Involvement
- Pharmaceutical industry and healthcare
- Dementia and Cognitive Impairment Research
- Inflammatory mediators and NSAID effects
- Adolescent and Pediatric Healthcare
- Delphi Technique in Research
- Liver Disease Diagnosis and Treatment
- Diabetes Management and Research
- Healthcare cost, quality, practices
- Pediatric Pain Management Techniques
- Musculoskeletal pain and rehabilitation
- Patient Safety and Medication Errors
Manchester Academic Health Science Centre
2017-2025
University of Manchester
2011-2025
Australian Football League
2024
NIHR Manchester Biomedical Research Centre
2024
University of Rochester
2024
University of Cambridge
2018-2023
Cambridgeshire and Peterborough NHS Foundation Trust
2018-2023
National Health Service
2018-2023
MRC Cognition and Brain Sciences Unit
2018-2023
Medical Research Council
2018-2023
Background: UK care home residents are often poorly served by existing healthcare arrangements. Published descriptions of residents’ health status have been limited lack detail and use data derived from surveys drawn social, rather than health, records. Aim: to describe in the resource Design setting: a 180-day longitudinal cohort study 227 across 11 homes, 5 nursing 6 residential, selected be representative for nursing/residential dementia registration. Method: Barthel index (BI),...
Objectives To provide national estimates of the number and clinical economic burden medication errors in National Health Service (NHS) England. Methods We used UK-based prevalence (in prescribing, dispensing, administration monitoring) primary care, secondary care home settings, associated healthcare resource use, to estimate annual NHS. Burden (healthcare use deaths) was estimated from harm with avoidable adverse drug events (ADEs). Results that 237 million occur at some point process...
<b>Objective</b> To assess the impact of a pay for performance incentive on quality care and outcomes among UK patients with hypertension in primary care. <b>Design</b> Interrupted time series. <b>Setting</b> The Health Improvement Network (THIN) database, United Kingdom. <b>Participants</b> 470 725 diagnosed between January 2000 August 2007. <b>Intervention</b> (the Quality Outcomes Framework), which was implemented April 2004 included specific targets general practitioners to show high...
To examine the risk of gastrointestinal (GI) bleeding, major stroke and systemic embolism associated with prescribing nonsteroidal anti-inflammatory drugs (NSAIDs) to adults receiving oral anticoagulant (OAC) therapy.We conducted a population-based cohort study in OAC therapy using linked primary care (Clinical Practice Research Datalink GOLD) hospital (Hospital Episodes Statistics) electronic health records. We used cause-specific Cox regression models time-dependent NSAID treatment...
In persons with type 1 diabetes and high glycated hemoglobin levels, the benefits of intermittently scanned continuous glucose monitoring optional alarms for low blood levels are uncertain.
Abstract Objective To investigate risks of multiple adverse outcomes associated with use antipsychotics in people dementia. Design Population based matched cohort study. Setting Linked primary care, hospital and mortality data from Clinical Practice Research Datalink (CPRD), England. Adults (≥50 years) a diagnosis dementia between 1 January 1998 31 May 2018 (n=173 910, 63.0% women). Each new antipsychotic user (n=35 339, 62.5% women) was up to 15 non-users using incidence density sampling....
Abstract Purpose Recovery Colleges (RCs) have been implemented across England with wide variation in organisational characteristics. The purpose of this study is to describe RCs terms and student characteristics, fidelity annual spending, generate a RC typology based on characteristics explore the relationship between fidelity. Methods All meeting criteria recovery orientation, coproduction adult learning were included. Managers completed survey capturing budget. Hierarchical cluster...
Narratives describing first‐hand experiences of recovery from mental health problems are widely available. Emerging evidence suggests that engaging with narratives can benefit people experiencing problems, but no randomized controlled trial has been conducted as yet. We developed the Narrative Experiences Online (NEON) Intervention, a web application providing self‐guided and recommender systems access to collection recorded (n=659). investigated whether NEON Intervention benefited adults...
In response to high levels of demand for primary medical services in England, characterized by longer appointment waiting times and delayed referrals, the Government developed its National Health Service (NHS) Primary Care Recovery Plan. A key component plan is Pharmacy First (PF), which involves participating community pharmacies supplying prescription-only medicine after consultation with a pharmacist seven common conditions: earache, uncomplicated urinary tract infections women, sore...
Background: Azathioprine is an immunosuppressant prescribed for the treatment of inflammatory conditions and after organ transplantation. Risk neutropaenia has limited effective use azathioprine (AZA) driven requirements careful monitoring blood tests. Thiopurine methyltransferase (TPMT) a genetically moderated key enzyme involved in metabolism AZA that can be used to stratify individuals into different levels risk developing neutropaenia. Two techniques measure TPMT status: enzyme-level...
There is limited empirical evidence on patients' and healthcare professionals' views the provision of pharmacogenetic testing services. These opinions may be used to shape development emerging services inform future educational requirements.To explore about their development.Semi-structured interviews were conducted with patients who had been prescribed azathioprine for autoimmune conditions prevention acute rejection in renal transplantation. Focus groups a range professionals. Interviews...
To examine the effectiveness of New Medicine Service (NMS), a national community pharmacy service to support medicines-taking in people starting new medicine for long-term condition, compared with normal practice.Pragmatic patient-level parallel randomised controlled trial, 46 pharmacies England. Patients 1:1 block randomisation stratified by drug/disease group within each pharmacy. 504 participants (NMS: 251) aged 14 years and over, identified on presentation prescription asthma/chronic...
tools are required to identify high-risk older people in acute emergency settings so that appropriate services can be directed towards them.to evaluate whether the Identification of Seniors At Risk (ISAR) predicts clinical outcomes and health social costs discharged from medical units.an observational cohort study using receiver-operator curve analysis compare baseline ISAR an adverse outcome at 90 days (where was any death, institutionalisation, hospital readmission, increased dependency...
Hearing, vision, and cognitive impairment commonly co-occur in older adults. Improving sensory function may positively impact outcomes people with dementia (PwD). We developed a "sensory intervention" (SI) to support hearing vision PwD. Here, we report the findings of an international open-label field trial, nested case series, explore SI on dementia-related outcomes.This was home-based trial conducted France, England, Cyprus. Participants were mild-to-moderate and/or (n = 19) their study...
Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention support would reduce exacerbation rates over 12 months.Between October 2017 May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised the (data-logging nebulisers, digital platform...
Recovery colleges were developed in England to support the recovery of individuals who have mental health symptoms or illness. They been founded many countries but there has little international research on and no studies investigating their staffing, fidelity, costs. We aimed characterise internationally, understand organisational student characteristics, budget.In this cross-sectional study, we identified all which exist. repeated a survey done for 28 countries. In both surveys, defined as...