A5102944073- Health Systems, Economic Evaluations, Quality of Life
- Healthcare cost, quality, practices
- Hepatitis C virus research
- Lipoproteins and Cardiovascular Health
- Hepatitis B Virus Studies
- Esophageal and GI Pathology
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Chronic Disease Management Strategies
- Pharmaceutical Economics and Policy
- Healthcare Policy and Management
- Cardiac Arrest and Resuscitation
- Acute Myocardial Infarction Research
- Dysphagia Assessment and Management
- Marketing and Advertising Strategies
- Delphi Technique in Research
- Attention Deficit Hyperactivity Disorder
- Management and Marketing Education
- Statistical Methods in Clinical Trials
- Quality and Safety in Healthcare
- Cardiovascular Function and Risk Factors
- Gastroesophageal reflux and treatments
- Diabetes Treatment and Management
- Liver Disease Diagnosis and Treatment
- Cardiac Imaging and Diagnostics
- Biosimilars and Bioanalytical Methods
The University of Melbourne
2017-2025
St Vincent's Hospital
2011-2025
University of Manchester
2016-2025
Manchester Academic Health Science Centre
2017-2025
College of Central Florida
2024
University of Central Florida
2024
UCB Pharma (Belgium)
2022
Livingstone College
2021
University of Dundee
2017-2021
Genomics (United Kingdom)
2021
<b>Objective</b> To identify the number of drug-disease and drug-drug interactions for exemplar index conditions within National Institute Health Care Excellence (NICE) clinical guidelines. <b>Design</b> Systematic identification, quantification, classification potentially serious drugs recommended by NICE guidelines type 2 diabetes, heart failure, depression in relation to 11 other common those conditions. <b>Setting</b> <b>Main outcome measures</b> Potentially interactions. <b>Results</b>...
The EQ-5D-3L (3L) and EQ-5D-5L (5L) are both frequently used measures of health status. Previous studies have found the to superior measurement properties but no study has compared two in a large general population survey using matched respondents. Using data from GP Patient Survey, coarsened exact matching was match individuals completing 3L 2011 with those 5L 2012. Measurement were assessed for multimorbid (chronic conditions ≥ 2), ceiling effects, informativity distribution response...
Introduction: The advancement of precision medicine into routine clinical practice has been highlighted as an agenda for national and international health care policy. A principle barrier to this is in meeting requirements the payer or reimbursement agency care. This special report aims explain economic case medicine, by accounting explicit objectives defined decision-makers responsible allocation limited resources.Areas covered: framework cost-effectiveness analysis, a method evaluation,...
Chronic pulmonary infection with Pseudomonas aeruginosa is one of the most important causes mortality and morbidity in cystic fibrosis. If antibiotics are commenced promptly, can be eradicated. The aim trial was to compare effectiveness safety intravenous ceftazidime tobramycin versus oral ciprofloxacin eradication P aeruginosa.We did a multicentre, parallel group, open-label, randomised controlled 72 fibrosis centres (70 UK two Italy). Eligible participants were older than 28 days an...
Primary prevention of cardiovascular disease (CVD) is guided by risk-prediction tools, but these rarely account for the risk dying from other conditions (ie, competing mortality risk). In England and Wales, recommended tool QRISK2, a new version (QRISK3) has been derived internally validated. We aimed to externally validate QRISK3 assess effects on its predictive performance.
ABSTRACT Hepatitis B virus (HBV)-specific T-cell responses are important in the natural history of HBV infection. The number known HBV-specific epitopes is limited, and it not clear whether viral evolution occurs chronic We aimed to identify novel by examining relationship between sequence variation human leukocyte antigen (HLA) type a large prospective clinic-based cohort Asian patients with infection recruited Australia China ( n = 119). High-resolution 4-digit HLA class I II typing...
Summary Background Azathioprine and mercaptopurine are considered safe during pregnancy. However, the pharmacokinetic effects of pregnancy on thiopurine metabolism undefined. Aims To characterise in measure infant metabolite levels outcomes. Methods Women with IBD who were taking a pregnant or trying to conceive recruited. Maternal metabolites measured pre‐conception, each trimester, at delivery post‐partum. Infant levels, full blood examination liver function testing performed birth,...
Current consensus statements maintain that endoscopic vein harvesting (EVH) should be standard care in coronary artery bypass graft surgery, but quality and clinical outcomes have been questioned. The VICO trial (Vein Integrity Clinical Outcomes) was designed to assess the impact of different methods on vessel damage whether this contributes after grafting.In single-center, randomized trial, patients undergoing grafting with an internal mammary 1 4 grafts were recruited. All veins harvested...
Background Multimorbidity is common but most clinical guidelines focus on single diseases. Aim To test the feasibility of new approaches to developing single-disease better account for multimorbidity. Design Literature-based and economic modelling project focused areas where multimorbidity makes guideline application problematic. Methods (1) Examination accounting in three exemplar National Institute Health Care Excellence (type 2 diabetes, depression, heart failure); (2) examination...
Herpes zoster (HZ) risk appears to vary by sex and geographic ancestry/ethnicity.In 2 randomized clinical trials, participants received doses of adjuvanted recombinant vaccine (RZV) or placebo intramuscularly, months apart. In this post-hoc analysis, we investigate efficacy RZV against HZ postherpetic neuralgia (PHN) sex, region, ancestry/ethnicity in ≥50-year-olds (ZOE-50: NCT01165177) ≥70-year-olds (pooled data from ZOE-50 ZOE-70: NCT01165229).Vaccine PHN was similar women men. Across...