A5091135056- Mosquito-borne diseases and control
- Global Maternal and Child Health
- Viral Infections and Vectors
- Child Nutrition and Water Access
- Leprosy Research and Treatment
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Respiratory viral infections research
- Viral Infections and Immunology Research
- Viral gastroenteritis research and epidemiology
- Tuberculosis Research and Epidemiology
- Malaria Research and Control
- Infection Control and Ventilation
- COVID-19 and healthcare impacts
- Maternal and Neonatal Healthcare
- COVID-19 Impact on Reproduction
- Reconstructive Surgery and Microvascular Techniques
- Infectious Encephalopathies and Encephalitis
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Cerebral Palsy and Movement Disorders
- COVID-19 and Mental Health
- Iron Metabolism and Disorders
- Breastfeeding Practices and Influences
- Autism Spectrum Disorder Research
London School of Hygiene & Tropical Medicine
2018-2025
University of Glasgow
2024
Universidade Federal Fluminense
2020-2024
Deakin University
2021-2023
Universidade Federal de Minas Gerais
2023
University of London
2020-2022
Amsterdam University Medical Centers
2021
Fundação Oswaldo Cruz
2020
London School of Theology
2020
Universidade Federal da Bahia
2020
Although leprosy is recognised as a disease of poverty, there little evidence on the specific socioeconomic factors associated with risk. To inform targeted strategies for elimination, we investigated markers risk in Brazil.
Prenatal exposure to Zika virus has potential teratogenic effects, with a wide spectrum of clinical presentation referred as congenital syndrome. Data on survival among children syndrome are limited.
Chikungunya virus outbreaks have been associated with excess deaths at the ecological level. Previous studies assessed risk factors for severe versus mild chikungunya disease. However, of death following disease compared in individuals without remains unexplored. We aimed to investigate 2 years
Abstract Whole-sporozoite vaccines confer sterilizing immunity to malaria-naive individuals by unknown mechanisms. In the first PfSPZ Vaccine trial ever in a malaria-endemic population, Vδ2 γδ T cells were significantly elevated and Vγ9/Vδ2 transcripts ranked as most upregulated vaccinees who protected from Plasmodium falciparum infection. mouse model, absence of during vaccination impaired protective CD8 cell responses ablated sterile protection. not required for circumsporozoite...
Testing of symptomatic persons for infection with severe acute respiratory syndrome coronavirus-2 is occurring worldwide. We propose two types case-control studies that can be carried out jointly in test settings persons. The first, the test-negative design (TND) easiest to implement; it only requires collecting information about potential risk factors Coronavirus Disease 2019 (COVID-19) from tested second, standard population controls, collection data on one or more controls each person who...
Abstract Background A longitudinal study was performed to determine the breadth, kinetics, and correlations of systemic mucosal antibody responses severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Methods Twenty-six unvaccinated adults with confirmed disease 2019 (COVID-19) were followed for 6 months 3 collections blood, nasal secretions, stool. Control samples obtained from 16 uninfected individuals. SARS-CoV-2 neutralizing binding respectively evaluated by pseudovirus...
Lymphocytic esophagitis (LE) is a histologic pattern with no established clinical correlates in the majority of patients. The goal this study was to evaluate association between nonachalasia primary esophageal motility disorders (PEMD) and LE. Sixty-nine patients PEMD biopsies, including 22 nutcracker esophagus, 33 ineffective motility, 14 diffuse spasm, constituted group. control group consisted 70 severe dysmotility-negative gastroesophageal reflux disease requiring referral for Nissen...
The main goal of this manuscript was to investigate the neurodevelopment children exposed by Zika virus in intrauterine period who are asymptomatic at birth. Newborns with documented exposure during were birth followed first two years life for using Bayley III test. Children classified as having normal or delayed age based on most recent evaluation results. Eighty-four infants included study. performed a mean chronological 9.7±3.1 month; 13 (15%) had delay one three domains, distributed...
Knowledge regarding the risks associated with Zika virus (ZIKV) infections in pregnancy has relied on individual studies relatively small sample sizes and variable risk estimates of adverse outcomes, or surveillance routinely collected data. Using data from Brazilian Cohorts Consortium, this study aims, to estimate outcomes among offspring women RT-PCR-confirmed ZIKV infection during explore heterogeneity between studies.We performed an participant meta-analysis 1548 pregnant 13 studies,...
BackgroundAlthough household contacts of patients with tuberculosis are known to be particularly vulnerable tuberculosis, the published evidence focused on this group at high risk within low-income and middle-income country context remains sparse. Using nationwide data from Brazil, we aimed estimate incidence investigate socioeconomic clinical determinants in a cohort patients.MethodsIn study, linked individual demographic 100 Million Brazilian Cohort mortality registries, identified index...
Identification of mechanisms that limit poliovirus replication is crucial for informing decisions aimed at global polio eradication. Studies mucosal immunity induced by oral (OPV) or inactivated (IPV) vaccines and mixed schedules thereof will determine the effectiveness different vaccine strategies to block virus shedding. We used samples from a clinical trial vaccination measure intestinal as judged neutralisation virus-specific IgA in stools.In FIDEC trial, Latin American infants were...
Despite progress toward reducing global incidence, leprosy control remains a challenge in low- and middle-income countries.To estimate new case detection rates of among household contacts patients with previously diagnosed to investigate its associated risk factors.This population-based cohort study included families registered the 100 Million Brazilian Cohort linked nationwide registries leprosy; data were collected from January 1, 2007, through December 31, 2014. Household previous...
Congenital viral infections and the occurrence of septo-optic dysplasia, which is a combination optic nerve hypoplasia, abnormal formation structures along midline brain, pituitary hypofunction, support biological plausibility endocrine dysfunction in Zika-related microcephaly. In this case series we ascertained presence describe 30 children with severe microcephaly from MERG Pediatric Cohort, referred for endocrinological evaluation between February August 2019. Of children, 97% had The...
Abstract Objective To estimate the incidence of epilepsy in children with Zika‐related microcephaly first 24 months life; to characterize associated clinical and electrographic findings; summarize treatment responses. Methods We followed a cohort children, born during 2015‐2016 Zika virus (ZIKV) epidemic Brazil, congenital evidence ZIKV infection on neuroimaging and/or laboratory testing. Neurological assessments were performed at ≤3, 6, 12, 15, 18, 21, life. Serial electroencephalograms...
Indirect financial costs and barriers to health-care access might contribute leprosy treatment non-adherence. We estimated the association of Brazilian conditional cash transfer programme, Programa Bolsa Família (PBF), on adherence cure in patients Brazil.
We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of Rio de Janeiro epidemic 2015-2016. Serum and urine collected from birth through first year life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM MAC-ELISA. Four hundred seven specimens are evaluated; 161 sera PCR assays, 85 urines PCR. Sixty-five percent children (N = 84) positive least one assay. Of 94 within 3 months age, 70% positive. Positivity...
Abstract This study aimed to estimate the risks of adverse infant outcomes in first year life related prenatal Zika virus (ZIKV) exposure. A prospective cohort pregnant women with rash was recruited Central-West Brazil a post-epidemic period (January 2017 April 2019). We evaluated participants’ medical histories and performed ZIKV diagnostic testing using molecular (reverse transcription polymerase chain reaction [RT-PCR]) serologic (immunoglobulin [Ig]M plaque reduction neutralization tests...
Background Congenital Zika Syndrome (CZS) has been linked to a wide spectrum of abnormalities. However, differences in hospitalization patterns between children with and without CZS have not yet investigated. Methods We compared rates hospital admissions for all specific diseases, proportions admission causes, total length stay (LOS) those the syndrome. Adjusted incidence rate ratios (aIRR) aLOS were estimated using negative binomial regression. Results Compared CZS, aIRR all-cause...