A5053745189- Mosquito-borne diseases and control
- Asthma and respiratory diseases
- COVID-19 epidemiological studies
- Global Maternal and Child Health
- Viral Infections and Vectors
- Food Allergy and Anaphylaxis Research
- Allergic Rhinitis and Sensitization
- Healthcare during COVID-19 Pandemic
- Dermatology and Skin Diseases
- Eosinophilic Esophagitis
- Physical Education and Gymnastics
- Complex Network Analysis Techniques
- Helicobacter pylori-related gastroenterology studies
- Parasitic Infections and Diagnostics
- Virology and Viral Diseases
- HIV/AIDS Research and Interventions
- Evolutionary Algorithms and Applications
- Neonatal and Maternal Infections
- SARS-CoV-2 and COVID-19 Research
- Environmental Sustainability and Education
- Pediatric health and respiratory diseases
- Immune Cell Function and Interaction
- Parasites and Host Interactions
- Breastfeeding Practices and Influences
- Vaccine Coverage and Hesitancy
University of Cambridge
2024
Fundação Oswaldo Cruz
2018-2024
Babraham Institute
2022-2024
Knowledge Integration (United Kingdom)
2022-2024
Universidade Federal do Pará
2023
Universidade Federal da Bahia
2010-2021
Universidade Estadual de Ponta Grossa
2018
Universidade Federal de Juiz de Fora
2015-2017
Karolinska Institutet
2010
Juntendo University
2010
Prenatal exposure to Zika virus has potential teratogenic effects, with a wide spectrum of clinical presentation referred as congenital syndrome. Data on survival among children syndrome are limited.
Abstract COVID-19 is affecting healthcare resources worldwide, with lower and middle-income countries being particularly disadvantaged to mitigate the challenges imposed by disease, including availability of a sufficient number infirmary/ICU hospital beds, ventilators, medical supplies. Here, we use mathematical modelling study dynamics in Bahia, state northeastern Brazil, considering influences asymptomatic/non-detected cases, hospitalizations, mortality. The impacts policies on...
Toxocara canis and T. cati are parasites of dogs cats, respectively, that infect humans cause human toxocariasis. Infection may asthma-like symptoms but is often asymptomatic associated with a marked eosinophilia. Previous epidemiological studies indicate infection be the development atopy asthma.To investigate possible associations between spp. seropositivity childhood wheezing in population children living non-affluent areas large Latin American city.The study was conducted city Salvador,...
Helminths are modulators of the host immune system, and infections with these parasites have been associated protection against allergies autoimmune diseases. The human is often infected multiple helminth most studies to date investigated effects helminths in context single parasite or types (e.g. geohelminths). In this study, we how co-infections three nematodes affect markers allergic inflammation asthma children. We selected Ascaris lumbricoides Trichuris trichiura, two that inhabit...
Interleukin 2 (IL-2) is a key homeostatic cytokine, with therapeutic applications in both immunogenic and tolerogenic immune modulation. Clinical use has been hampered by pleiotropic functionality widespread receptor expression, unexpected adverse events. Here, we developed novel mouse strain to divert IL-2 production, allowing identification of contextual outcomes. Network analysis identified priority access for Tregs competitive fitness cost production among conventional CD4 T cells. CD8...
The advent of high-dimensional single-cell data has necessitated the development dimensionality-reduction tools. t-Distributed stochastic neighbor embedding (t-SNE) and uniform manifold approximation projection (UMAP) are two most frequently used approaches, allowing clear visualization complex datasets. Despite need for quantitative comparison, t-SNE UMAP have largely remained tools due to lack robust statistical approaches. Here, we derived a test evaluating difference between...
Abstract Background: Helicobacter pylori infection has been proved to be of great relevance public health in unindustrialized countries, especially low socioeconomic groups. Poor hygiene, deficient sanitation, and crowded conditions have reported as risk factors for this infection. In work, we investigated whether social demographic characteristics were associated with anti‐ H. IgG antibodies 1104 children aged 4–11 years old from Salvador, a large city located northeastern Brazil. Methods:...
The clinical manifestations of microcephaly/congenital Zika syndrome (microcephaly/CZS) have harmful consequences on the child's health, increasing vulnerability to childhood morbidity and mortality. This study analyzes case fatality rate child-maternal characteristics cases deaths related microcephaly/CZS in Brazil, 2015-2017. Population-based developed by linkage three information systems. We estimate frequencies cases, deaths, according child maternal causes death. Multivariate logistic...
The increase in global polymer production has raised concerns about the environmental impacts caused by inappropriate disposal of these materials. One widely used alternative to mitigate this problem is reduce consumption virgin raw materials through recycling processes. In study, mixtures and recycled polypropylene, derived from waste manufacturing parts for two-wheeled vehicles, proportions 5, 10 15%, were analyzed evaluate impact on mechanical properties tensile strength, hardness impact....
Este estudo teve como objetivo analisar o papel da dança terapia complementar para idosos com doenças cardiovasculares, por meio de uma revisão literatura. Foram selecionados artigos publicados entre 2010 e 2024 nas bases PubMed, SciELO, Google Scholar ScienceDirect, utilizando os descritores “dança”, “idosos” “doenças cardiovasculares”. A análise qualitativa do conteúdo permitiu a categorização dos dados em eixos temáticos, melhora função cardiorrespiratória, controle pressão arterial,...
O Infarto Agudo do Miocárdio (IAM) é uma das principais causas de mortalidade cardiovascular, geralmente decorrente da ruptura placas ateroscleróticas e formação trombos nas artérias coronárias. Durante a pandemia COVID-19, observou-se um aumento significativo eventos cardiovasculares, com destaque para o IAM. A infecção pelo SARS-CoV-2 atua como fator precipitante, agravando disfunção endotelial, promovendo inflamação sistêmica aumentando coagulabilidade sanguínea. Esses mecanismos, aliados...
Este estudo teve como objetivo investigar, por meio de uma revisão literatura, as estratégias educação em saúde voltadas para a prevenção quedas idosos. As representam um grave problema pública, sendo responsáveis altos índices morbimortalidade nessa população. A pesquisa foi realizada nas bases dados PubMed, SciELO, Google Scholar e ScienceDirect, utilizando os descritores “quedas idosos”, “educação saúde” “prevenção acidentes”. Foram incluídos artigos publicados entre 2010 2024, português...
BackgroundEnvironmental factors are likely to have profound effects on the development of host immune responses, with serious implications for infectious diseases and inflammatory disorders such as asthma.ObjectiveThis study was designed investigate environmental exposures cytokine profile children.MethodsThe involved measurement T helper (Th) 1 (interferon-gamma), 2 [interleukin (IL)-5 IL-13], regulatory IL-10 in unstimulated peripheral blood leukocytes from 1,376 children 4–11 years age...
Abstract HIV-1 has diversified into several subtypes and recombinant forms that are heterogeneously spread around the world. Understanding distribution of viral variants their temporal dynamics can help to design vaccines monitor changes in transmission patterns. Brazil one largest epidemics western-world molecular features virus circulating country still not completely known. Over 50,000 partial genomes sampled between 2008 2017 by Brazilian genotyping network (RENAGENO) were analyzed....
Toxoplasmosis is a cosmopolitan protozoan infection. Data regarding risk factors for the post-natal acquisition of Toxoplasma gondii infection in childhood are limited. We conducted serological survey T. IgG antibodies and associated 1,217 children 4–11-yr-old from Salvador, Brazil, using commercial ELISA kit; were found 17.5% children. Age (OR = 2.18; 95% CI: 1.50–3.17) maternal schooling level 0.62; 0.42–0.92) negatively with A greater number siblings 1.53; 1.12–2.09), cat at home 1.54;...
Abstract Background The prevalence of allergic diseases has increased over recent decades in affluent countries, but remains low rural populations and some non-affluent countries. An explanation for these trends is that exposure to infections may provide protection against the development allergy. In this work we investigated association between viral children living urban Brazil atopy asthma. Methods School age poor neighborhoods city Salvador were studied. Data on asthma symptoms relevant...
Asthma is a chronic inflammatory disease of the airways that heterogeneous and multifactorial, making its accurate characterization complex process. Therefore, identifying genetic variations associated with asthma discovering molecular interactions between omics confer risk developing this will help us to unravel biological pathways involved in pathogenesis.
Ethno-racial inequalities are critical determinants of health outcomes. We quantified ethnic-racial on adverse birth outcomes and early neonatal mortality in Brazil.
Abstract Background Two conditions are used as markers of atopy: the presence circulating anti-allergen IgE antibodies and positive skin prick test (SPT) reactions to allergenic extracts. The correlation between these is not absolute. This study aimed at investigating immunological parameters that may mediate this lack correlation. Individuals whose sera contained anti- B. tropicalis extract (α -Bt E IgE) were divided into two groups, according or absence reactivity ( Bt E). following...