A5100739314- Mosquito-borne diseases and control
- Viral Infections and Vectors
- interferon and immune responses
- Immune Response and Inflammation
- Autoimmune and Inflammatory Disorders Research
- Virology and Viral Diseases
- Liver Disease Diagnosis and Treatment
- Pediatric health and respiratory diseases
- COVID-19 Impact on Reproduction
- Viral Infections and Outbreaks Research
- COVID-19 Clinical Research Studies
- Viral Infections and Immunology Research
- Reproductive System and Pregnancy
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Advanced Glycation End Products research
- Immune cells in cancer
- Hepatitis B Virus Studies
- Inflammasome and immune disorders
- Flavonoids in Medical Research
- S100 Proteins and Annexins
- Aquaculture disease management and microbiota
- Immune responses and vaccinations
- Osteomyelitis and Bone Disorders Research
Cleveland Clinic Lerner College of Medicine
2021-2024
University of Southern California
2016-2024
Feinstein Institute for Medical Research
2019-2024
Northwell Health
2019-2024
Donald & Barbara Zucker School of Medicine at Hofstra/Northwell
2019-2024
Case Western Reserve University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
University of Chinese Academy of Sciences
2023
Institute of Modern Physics
2019-2023
Chinese Academy of Sciences
2023
Due to the urgent need of a therapeutic treatment for coronavirus (CoV) disease 2019 (COVID-19) patients, number FDA-approved/repurposed drugs have been suggested as antiviral candidates at clinics, without sufficient information. Furthermore, there extensive debates over their effectiveness and safety against severe acute respiratory syndrome CoV 2 (SARS-CoV-2), suggesting that rapid preclinical animal studies are required identify potential human trials. To this end, efficacies...
Abstract Respiratory distress (RD) has been reported in SARS-CoV-2 exposed uninfected (SEU) term neonates. Prior studies suggest that prenatal exposure to Coronavirus Disease 19 (COVID-19) may activate an inflammatory cascade the newborn airway. In this study, we examine relationship between maternal COVID-19 vaccination and neonatal RD using a longitudinal cohort of mother-infant pairs Los Angeles, CA. Two-hundred twenty-one mothers with laboratory confirmed during pregnancy 227 fetuses are...
ABSTRACT The recent global resurgence of arthritogenic alphaviruses, in particular chikungunya virus (CHIKV), highlights an urgent need for the development therapeutic intervention strategies. While there has been significant progress defining pathophysiology alphaviral disease, relatively little is known about mechanisms involved CHIKV-induced arthritis or potential options to treat severe arthritic symptoms associated with infection. Here, we used microcomputed tomographic (μCT) and...
Significance Persistent polyarthritis, which occurs in 30–40% of alphavirus-infected patients, has been proposed to be caused by proinflammatory mediators such as IL-6. In the present study we investigated susceptibility and response primary human osteoblasts Ross River virus (RRV) infection determined whether could result bone pathology. RRV resulted increased receptor activator nuclear factor-kappaB ligand (RANKL) but decreased osteoprotegerin (OPG). We are first report that alphavirus...
Acute lung injury (ALI) is a fatal disease in the absence of pharmacological treatment. Oxidative stress and inflammation are closely related to ALI. Innate immune cells main source reactive oxygen species (ROS). Macrophages play an extremely important role ALI through activation oxidative stress. Itaconate, metabolite tricarboxylic acid, has been reported have strong antioxidant anti-inflammatory effects. However, itaconate unclear. Herein, we use 4-octyl (OI), cellular permeable derivate...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers cytokine-mediated inflammation, leading to a myriad of clinical presentations in COVID-19. The SARS-CoV-2 open reading frame 8 (ORF8) is secreted and rapidly evolving glycoprotein. Patients infected with variants ORF8 deleted are associated mild disease outcomes, but the molecular mechanism behind this unknown. Here, we report that viral cytokine similar distinct from interleukin 17A (IL-17A) as it induces...
Abstract RIPK3–ZBP1–MLKL-mediated necroptosis is a proinflammatory cell death process that crucial for antiviral host defence. RIPK3 self-oligomerization and autophosphorylation are prerequisites executing necroptosis, yet the underlying mechanism of virus-induced activation remains elusive. Interferon-inducible 2′-5′ oligoadenylate synthetase-like (OASL) protein devoid enzymatic function but displays potent activity. Here we describe role OASL as promoter scaffolds RIPK3–ZBP1 non-canonical...
Objective To evaluate neuromotor repertoires and developmental milestones in infants exposed to antenatal COVID-19. Design Longitudinal cohort study. Setting Hospital-based study Los Angeles, USA Rio de Janeiro, Brazil between March 2020 December 2021. Participants Infants born mothers with COVID-19 during pregnancy prepandemic control from the Graz University Database. Interventions General movement assessment (GMA) videos 3 5 months post-term age were collected clinical...
Thioredoxin-interacting protein (TXNIP) has emerged as a key player in cancer and diabetes since it targets thioredoxin (TRX)-mediated redox regulation glucose transporter (GLUT)-mediated metabolism. TXNIP consists of two arrestin (ARR, N-ARR C-ARR) domains at its amino-terminus PPxY (PY) motifs di-leucine (LL) motif for endocytosis carboxyl-terminus. Here, we report that shuffles between TRX GLUTs to regulate homeostasis intracellular oxidative stress While functions gatekeeper by default,...
<h3>Importance</h3> Congenital Zika virus (ZIKV) infection may present with a spectrum of clinical and neuroradiographic findings. <h3>Objective</h3> To determine whether neuroimaging findings for infants history ZIKV exposure are associated infant outcomes gestational age at antenatal infection. <h3>Design, Setting, Participants</h3> This cohort study retrospectively reviewed results (computed tomography and/or magnetic resonance imaging scans) 110 ZIKV-exposed from maternity children's...
Is Cannabis a boon or bane? sativa has long been versatile crop for fiber extraction (industrial hemp), traditional Chinese medicine (hemp seeds), and recreational drugs (marijuana). faced global prohibition in the twentieth century because of psychoactive properties ∆9-tetrahydrocannabinol; however, recently, perspective changed with recognition additional therapeutic values, particularly pharmacological potential cannabidiol. A comprehensive understanding underlying mechanism cannabinoid...
Human blood monocytes play a central role in dengue infections and form the majority of virus infected cells blood. are heterogeneous divided into CD16(-) CD16(+) subsets. Monocyte subsets distinct roles during disease, but it is not currently known if monocyte differentially contribute to protection pathogenesis. Here, we compared susceptibility response human primary vitro. We found that both were equally susceptible (DENV2 NGC), capable supporting initial production new infective...
ABSTRACT Arthritogenic alphaviruses such as Ross River virus (RRV) and chikungunya (CHIKV) cause large-scale epidemics of severe musculoskeletal disease have been progressively expanding their global distribution. Since its introduction in July 2014, CHIKV now circulates the United States. The hallmark alphavirus is crippling pain inflammation joints, a similar immunopathology to rheumatoid arthritis. use glycans novel therapeutics an area research that has increased recent years. Here, we...
We report Zika virus (ZIKV) vertical transmission in 130 infants born to PCR+ mothers at the time of Rio de Janeiro epidemic 2015-2016. Serum and urine collected from birth through first year life were tested by quantitative reverse transcriptase polymerase chain reaction (PCR) and/or IgM MAC-ELISA. Four hundred seven specimens are evaluated; 161 sera PCR assays, 85 urines PCR. Sixty-five percent children (N = 84) positive least one assay. Of 94 within 3 months age, 70% positive. Positivity...