A5060073573- Influenza Virus Research Studies
- Biopolymer Synthesis and Applications
- Immunotherapy and Immune Responses
- RNA Interference and Gene Delivery
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- Cancer Research and Treatments
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Bacteriophages and microbial interactions
- Antimicrobial Peptides and Activities
- Immune Response and Inflammation
- Animal Virus Infections Studies
- COVID-19 Clinical Research Studies
- Probiotics and Fermented Foods
- Viral Infections and Vectors
- Viral Infectious Diseases and Gene Expression in Insects
- Virus-based gene therapy research
- Cell Adhesion Molecules Research
- Cervical Cancer and HPV Research
- SARS-CoV-2 detection and testing
- Advanced biosensing and bioanalysis techniques
- Microbial Community Ecology and Physiology
- Nanoplatforms for cancer theranostics
Konkuk University
2023-2024
Korea Research Institute of Bioscience and Biotechnology
2013-2023
Korea University of Science and Technology
2011-2022
Institute for Bioscience and Biotechnology Research
2021
Research Institute for Bioscience and Biotechnology
2021
Yonsei Proteome Research Center
2007-2013
Chungnam National University
2013
Korea Research Institute of Chemical Technology
2013
Kookmin University
2011
Bioleaders (South Korea)
2011
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe acute respiratory syndrome 2 (SARS-CoV-2) and influenza A virus (IAV) is a major concern for public health. However, immunopathogenic events occurring with coinfections SARS-CoV-2 IAV remain unclear. Here, we report pathogenic immunological consequences H1N1 in K18-hACE2 transgenic mouse model. Compared single infection or IAV, not only prolonged primary period but also increased immune cell infiltration...
Abstract Poly‐γ‐glutamic acid (γ‐PGA) is a very promising biodegradable polymer that produced by Bacillus subtilis. γ‐PGA water‐soluble, anionic, biodegradable, and edible. This paper reviews the production of strain recent developments with respect to applications in terms Ca absorption, moisturizing properties, conjugation, super absorbent polymer, so on. Our research shows can be used as an immune‐stimulating anti‐tumor agent, especially at high molecular weight. © 2005 The Japan Chemical...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers cytokine-mediated inflammation, leading to a myriad of clinical presentations in COVID-19. The SARS-CoV-2 open reading frame 8 (ORF8) is secreted and rapidly evolving glycoprotein. Patients infected with variants ORF8 deleted are associated mild disease outcomes, but the molecular mechanism behind this unknown. Here, we report that viral cytokine similar distinct from interleukin 17A (IL-17A) as it induces...
African swine fever (ASF) is a highly contagious hemorrhagic disease in domestic pigs and wild boars caused by virus (ASFV). ASF deadly epidemic the global pig industry, but no drugs or vaccines are available.
Induction of mucosal immunity may be important for preventing SARS-CoV infections. For safe and effective delivery viral antigens to the immune system, we have developed a novel surface antigen display system lactic acid bacteria using poly-gamma-glutamic synthetase A protein (PgsA) Bacillus subtilis as an anchoring matrix. Recombinant fusion proteins comprised PgsA Spike (S) segments SA (residues 2 114) SB 264 596) were stably expressed in Lactobacillus casei. Surface localization was...
Abstract During the 2006–2007 winter season in South Korea, several outbreaks of highly pathogenic avian influenza virus (H5N1) were confirmed among domestic poultry and migratory bird habitats. Phylogenetic analysis showed that all isolates closely related belong to A/bar-headed goose/Qinghai/5/2005–like lineage rather than A/chicken/Korea/ES/2003–like lineage.
In the past 4 years, incidences of endemic or epidemic respiratory diseases associated with canine influenza H3N2 virus in Asian dogs have been reported countries such as South Korea and China. Canine species were considered to be new natural hosts for this virus. However, at beginning 2010, influenza-like signs, dyspnoea, also observed among cats well an animal shelter located Seoul, Korea. The affected showed 100 % morbidity 40 mortality. We able isolate a from lung specimen dead cat,...
(See the article by O'Brien et al, on pages 252–61, and editorial commentary Beck 172–3.)
We analyzed the in vivo tumor regression activity of high molecular mass poly-gamma-glutamate (gamma-PGA) from Bacillus subtilis sups. chungkookjang. C57BL/6 mice were orally administered 10-, 100-, or 2000-kDa gamma-PGA beta-glucan (positive control), and antitumor immunity was examined. Our results revealed higher levels NK cell-mediated cytotoxicity IFN-gamma secretion treated with (2000 kDa) vs those lower (10 100 beta-glucan. then examined effect oral administration 10- on protection...
Due to dual susceptibility both human and avian influenza A viruses, pigs are believed be effective intermediate hosts for the spread production of new viruses with pandemic potential. In early 2008, two swine H5N2 were isolated from our routine surveillance in Korea. The sequencing phylogenetic analysis surface proteins revealed that Sw/Korea/C12/08 Sw/Korea/C13/08 derived Eurasian lineage. However, although isolate is an entirely avian-like virus, avian-swine-like reassortant PB2, PA, NP,...
Background The ectodomain of matrix protein 2 (M2e) influenza A virus is a rationale target antigen candidate for the development universal vaccine against as M2e undergoes little sequence variation amongst human strains. Vaccine-induced M2e-specific antibodies (Abs) have been shown to display significant cross-protective activity in animal models. M2e-based constructs be more protective when administered by intranasal (i.n.) route than after parenteral injection. However, i.n....
Andrographolide (AG) is an abundant component of plants the genus Andrographis and has a number beneficial properties including neuroprotective, anticancer, anti-inflammatory, antidiabetic effects. Despite numerous pharmacological studies, precise mechanism AG still ambiguous. Thus, in present study, we investigated molecular mechanisms its target proteins as they pertain to anti-inflammatory responses. suppressed production nitric oxide (NO) prostaglandin E 2 (PGE ), well mRNA abundance...
Here, we describe an easy but robust chemical strategy to synthesize high-performance magnetic resonance (MR)/near-infrared (NIR) multimodal imaging nanoprobes. Poly(γ-glutamic acid) was used for the convenient phase transfer of MnFe2O4 nanoparticles dispersed in organic solvents into aqueous solutions and facilitated further ionic gelation with poly(l-lysine). During process, nanoparticulate satellites were encapsulated nanocomplex, which induced synergistic magnetism resulted huge T2...
ABSTRACT Due to dual susceptibility both human and avian influenza A viruses, pigs are believed be effective intermediate hosts for the spread production of new viruses with pandemic potential. In early 2008, two swine H5N2 were isolated from our routine surveillance in Korea. The sequencing phylogenetic analysis surface proteins revealed that Sw/Korea/C12/08 Sw/Korea/C13/08 derived Eurasian lineage. However, although isolate is an entirely avian-like virus, avian-swine-like reassortant PB2,...
A Gram-negative-staining, non-motile rod, designated GG-w14(T), was isolated from the rhizosphere of Angelica polymorpha Maxim. Phylogenetic analysis 16S rRNA gene sequences revealed that isolate belonged to genus Mucilaginibacter and exhibited 93.9-97.4% sequence similarity with recognized members (closest relative gossypii Gh-67(T)). DNA-DNA relatedness between strain GG-w14(T) M. KCTC 22380(T) <41%. Strain grew at 4-35 °C, pH 5.0-8.0 0-1% (w/v) NaCl. The hydrolysed casein, CM-cellulose...
Various treatments and agents had been reported to inactivate RNA viruses. Of these, thermal inactivation is generally considered an effective cheap method of sample preparation for downstream assays. The purpose this study establish a safe SARS-CoV-2 without compromising the amount amplifiable viral genome necessary clinical diagnoses. In study, we demonstrate infectivity genomic stability SARSCoV- 2 by at both 56°C 65°C. results substantiate that viable readily inactivated when incubated...
The mounting of a specific immune response against the human papillomavirus type 16 E7 protein (HPV16 E7) is important for eradication HPV16 E7-expressing cancer cells from cervical mucosa. To induce mucosal by oral delivery antigen, we expressed antigen on surface Lactobacillus casei employing novel display system in which poly-gamma-glutamic acid (gamma-PGA) synthetase complex A (PgsA) Bacillus subtilis (chungkookjang) was used as an anchoring motif. After expression confirmed Western...