A5046181932- Influenza Virus Research Studies
- Respiratory viral infections research
- Animal Disease Management and Epidemiology
- Caching and Content Delivery
- Viral gastroenteritis research and epidemiology
- Algorithms and Data Compression
- Animal Virus Infections Studies
- Immune Cell Function and Interaction
- Advanced Data Storage Technologies
- vaccines and immunoinformatics approaches
- Immune Response and Inflammation
- Hair Growth and Disorders
- Diverse Approaches in Healthcare and Education Studies
- SARS-CoV-2 and COVID-19 Research
- Education and Learning Interventions
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- Skin and Cellular Biology Research
- Virology and Viral Diseases
- Mosquito-borne diseases and control
- Malaria Research and Control
- Advanced Image and Video Retrieval Techniques
- Bacteriophages and microbial interactions
- Cellular Mechanics and Interactions
- Herbal Medicine Research Studies
Korea University
2015-2024
Korea Aerospace University
2024
Korea Institute of Science and Technology
2022
Korean Association Of Science and Technology Studies
2022
Chemical Synthesis Lab
2019
Chosun University
2019
Catholic University of Korea
2018
Columbia University
2018
Seoul National University
2016
Sejong University
2014
While the molecular mechanism of membrane fusion by influenza virus hemagglutinin (HA) protein has been studied extensively in vitro, role acid-dependent HA activation replication, pathogenesis, and transmission vivo not characterized. To investigate biological significance pH protein, we compared properties four recombinant viruses with altered acid stability to those wild-type A/chicken/Vietnam/C58/04 (H5N1) vitro mallards. Membrane was activated at 5.9. Wild-type had a calculated...
During recent canine influenza surveillance in South Korea, a novel H3N1 virus (CIV) that is putative reassortant between pandemic H1N1 2009 and H3N2 CIVs was isolated. Genetic analysis of eight genes the revealed isolate presented high similarities (99.1-99.9 %) to H1N1, except for haemagglutinin (HA) gene. The HA gene nucleotide sequence CIV similar (99.6 isolated Korea China. Dogs infected with did not show any notable symptoms, contrast dogs CIV. Despite no visible clinical signs...
We produced a monoclonal antibody (MAb) (7G10) that has blocking activity against porcine reproductive and respiratory syndrome virus (PRRSV). In this study, we identified the components of 7G10 MAb-bound complex as cytoskeletal filaments: vimentin, cytokeratin 8, 18, actin, hair type II basic keratin. Vimentin bound to PRRSV nucleocapsid protein anti-vimentin antibodies showed PRRSV-blocking activity. was expressed on surface MARC-145, PRRSV-susceptible cell line. Simian vimentin rendered...
In Egypt, efforts to control highly pathogenic H5N1 avian influenza virus in poultry and humans have failed despite increased biosecurity, quarantine, vaccination at farms. The ongoing circulation of HP Egypt has caused >100 human infections remains an unresolved threat veterinary public health. Here, we describe that the failure commercially available H5 vaccines may be part by passive transfer maternal antibodies chicks, inhibiting their immune response vaccination. We propose induction...
(See the article by O'Brien et al, on pages 252–61, and editorial commentary Beck 172–3.)
Abstract Background Porcine reproductive and respiratory syndrome virus (PRRSV) is a RNA causing diseases in swine. The susceptibility for PRRSV varies between the different breeds of In cell culture, can be propagated primary porcine alveolar macrophages some African green monkey kidney lines, such as MARC-145 cells. Previous studies have shown that 3' untranslated region (UTR) RNAs arteriviruses play an important role replication through interactions with cellular proteins. To better...
Waterfowl represent the natural reservoir of all subtypes influenza A viruses, including H5N1. Ducks are especially considered major contributors to spread H5N1 viruses because they exhibit diversity in morbidity and mortality. Therefore, as a preventive strategy against endemic well pandemic influenza, it is important reduce duck populations. Here, we describe pathogenicity dominant clades (clades 1 2) circulating birds Asia. Four representatives cause symptomatic infection but lead...
Abstract Zika virus (ZIKV) is a mosquito-borne member of the Flaviviridae family. ZIKV infection has been associated with neurological complications such as microcephaly in newborns and Guillain-Barré syndrome adults; thus, therapeutic agents are urgently needed. Statins clinically approved for lowering cholesterol levels to prevent cardiovascular disease but have shown potential antiviral drugs. In this study, we explored possibility utilizing statins anti-ZIKV We found that, generally,...
Interleukin-18 (IL-18) plays pivotal roles in linking inflammatory immune responses and tumor progression metastasis, yet the manner which this occurs remains to be sufficiently clarified. Here we report that hypoxia induces transcription secretion of IL-18, subsequently expression hypoxia-inducible factor-1α (HIF-1α). Mechanistically, IL-18 HIF-1α through activity GTPase Rac1, inducibly associates with receptor β (IL-18Rβ) subunit, via a PI3K-AKT-NF-κB–dependent pathway. Importantly,...
The influenza virus poses a global health burden. Currently, an annual vaccine is used to reduce virus-associated morbidity and mortality. Most vaccines have been developed elicit neutralizing Abs against virus. These primarily target immunodominant epitopes derived from hemagglutinin (HA) or neuraminidase (NA) of the incorporated in vaccines. However, HA NA are highly variable proteins that prone antigenic changes, which can efficacy. Therefore, it essential develop universal conserved...
We investigated the infectivity and transmissibility of human seasonal H3N2, pandemic (pdm) H1N1 (2009) B influenza viruses in dogs. Dogs inoculated with H3N2 pdm exhibited nasal shedding were seroconverted against viruses; this did not occur virus-inoculated Transmission virus between dogs was demonstrated by observing seroconversion naïve after contact The seroprevalence study offered evidence infection occurring since 2008. Furthermore, serological alone combination canine found serum...
Alternatively activated or M2 macrophages, as opposed to the well characterized pro-inflammatory M1 vitally regulate anti-inflammation, wound healing, and tissue repair maintain homeostasis. Although ubiquitous presence of macrophages in diverse tissues, exposed different physical environments, infers distinct immune responses with high phenotypic heterogeneity, underlying mechanism how varying extracellular mechanical conditions alter their immunological activation remains unclear. Here, we...
Marie Unna hereditary hypotrichosis (MUHH) is a rare autosomal dominant hair disorder. Through the study of mouse model, we identified mutation in 5′-untranslated region hairless (HR) gene patients with MUHH Caucasian family. The corresponding mutation, named 'hairpoor', was found mutant mice that were generated through N-ethyl-N-nitrosourea mutagenesis. Hairpoor mutants display partial loss at an early age and progress to near alopecia, which resembles phenotype. This conferred...
To elucidate the role of sparrows as intermediate hosts highly pathogenic avian influenza H5N1 viruses, we assessed shedding and interspecies waterborne transmission A/duck/Laos/25/06 in chickens. Inoculated birds shed virus at high titers from oropharynx cloaca, infection was fatal. Waterborne inoculated to contact chickens absent, while 25% were infected via The viral susceptibility observed sparrows, coupled with their presence poultry houses, could facilitate spread among wild face an outbreak.
ABSTRACT The migratory waterfowl of the world are considered to be natural reservoir influenza A viruses. Of 16 hemagglutinin subtypes avian viruses, H6 subtype is commonly perpetuated in its hosts and concern due potential a precursor highly pathogenic viruses by reassortment. During routine surveillance, we isolated an unconventional H6N5 virus. Experimental infection mice revealed that this isolate replicated efficiently lungs, subsequently spread systemically, caused lethality. also...
Since avian-origin H3N2 canine influenza virus (CIV) was first identified in South Korea 2008, the novel has been reported several countries Asia. Reverse zoonotic transmission of pandemic H1N1 (2009) (pH1N1) observed a broad range animal species. Viral dominance and characterization reassortants both viruses undertaken present study. Here we describe viral 23 CIV between pH1N1 from naturally co-infected dog. These results indicate that M gene HA are predominant reassortants. Furthermore,...