A5031923158- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- Influenza Virus Research Studies
- Virus-based gene therapy research
- Animal Disease Management and Epidemiology
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Vectors
- Viral Infections and Immunology Research
- Marine animal studies overview
- SARS-CoV-2 detection and testing
- Microbial infections and disease research
- Vector-Borne Animal Diseases
- Identification and Quantification in Food
- Virology and Viral Diseases
- Cephalopods and Marine Biology
- Aquaculture disease management and microbiota
- Immune Response and Inflammation
- Biosensors and Analytical Detection
- Genomics and Phylogenetic Studies
- Bird parasitology and diseases
- Bacteriophages and microbial interactions
- interferon and immune responses
- Xenotransplantation and immune response
- Bacterial biofilms and quorum sensing
Chungbuk National University
2019-2024
Hanbat National University
2023
Korea Research Institute of Bioscience and Biotechnology
2014-2021
Guangzhou Medical University
2021
Chungnam National University
2021
Institut Pasteur Korea
2021
Jeonbuk National University
2016
Seoul National University
2008-2015
University of Minnesota
2014-2015
Green Cross (South Korea)
2008-2015
Abstract Background Avian origin canine influenza virus was reported in Korea. The dog to contact transmission of the avian (CIV) H3N2 and CIV H3N8 shown by experimental transmission. This study focused on viral excretion fever order elucidate epidemiological associations which might be helpful control disease transmissions outbreak dogs. Methods An seronegative 10-week-old Beagle experimentally inoculated with A/canine/01/2007, subtype H3N2. Eight hours after inoculation, infected cohoused...
During recent canine influenza surveillance in South Korea, a novel H3N1 virus (CIV) that is putative reassortant between pandemic H1N1 2009 and H3N2 CIVs was isolated. Genetic analysis of eight genes the revealed isolate presented high similarities (99.1-99.9 %) to H1N1, except for haemagglutinin (HA) gene. The HA gene nucleotide sequence CIV similar (99.6 isolated Korea China. Dogs infected with did not show any notable symptoms, contrast dogs CIV. Despite no visible clinical signs...
Since severe acute respiratory syndrome (SARS) and Middle East (MERS) coronaviruses (CoVs) share similar characteristics with respect to clinical signs, etiology, transmission, methods for a rapid accurate differential diagnosis are important. Therefore, the aim of this study was develop duplex real-time reverse transcription (RT)-PCR method simultaneous detection these viruses. Primers probes that target conserved spike S2 region human SARS-CoV, MERS-CoV, their related bat CoVs were...
Susceptible dogs were brought into contact with experimentally infected an avian-origin influenza A virus (H3N2) that had been isolated from a pet dog severe respiratory syndrome. All the and contact-exposed showed elevated rectal temperatures, shedding, seroconversion, necrotizing tracheobronchitis bronchioalveolitis.
A virulent porcine epidemic diarrhea virus (PEDV) strain, DR13, was obtained from suckling pigs suspected of having in 1999 Korea, and its attenuated counterpart derived strain DR13 by serial propagation Vero cells. This report describes the first complete genome sequences PEDV counterpart, which will provide important insights into molecular basis attenuation PEDV.
Bat species around the world have recently been recognized as major reservoirs of several zoonotic viruses, such severe acute respiratory syndrome coronavirus (SARS-CoV), Middle East (MERS-CoV), Nipah virus and Hendra virus. In this study, consensus primer-based reverse transcriptase polymerase chain reactions (RT-PCRs) high-throughput sequencing were performed to investigate viruses in bat faecal samples collected at 11 natural habitat sites from July December 2015 Korea. Diverse...
Abstract Background There have been many efforts to develop efficient vaccines for the control of porcine reproductive and respiratory syndrome virus (PRRSV). Although inactivated PRRSV are preferred their safety, they weak at inducing humoral immune responses controlling field infection, especially when heterologous viruses involved. Results In all groups, sample positive (S/P) ratio IDEXX ELISA neutralization (VN) titer remained negative until challenge. While viremia did not reduce in...
Since the outbreak of coronavirus disease (COVID-19) in 2019, severe acute respiratory syndrome 2 (SARS-CoV-2) has evolved into diverse variants. Here, an early isolate SARS-CoV-2 was serially passaged multiple cell lines human origin triplicate, and selected mutations were compared to those found natural In spike protein, Q493R Q498R substitutions from viruses consistent with B.1.1.529 (Omicron) variant. Y144del H655Y also reported B.1.1.7 (Alpha), P.1 (Gamma), Several single nucleotide...
Background The emergence of zoonotic viruses in domestic animals is a significant public health concern. Canine influenza virus (CIV) H3N2 that can infect companion and is, therefore, potential Objective This study investigated the inter- intraspecies transmission CIV among dogs, cats, ferrets, under laboratory conditions, to determine whether was possible between as well within these animal species. Method routes for were airborne direct contact, respectively. Transmission conducted through...
We report the identification of a novel single-stranded, circular DNA virus isolated from bovine stool. The virus, named stool-associated (BoSCV), has genome comprising 2600 bases ssDNA, with two putative ORFs encoding replicase and capsid proteins, arranged inversely. stem–loop structure was located between 3′ ends ORFs, as in chimpanzee (ChimpSCV) unlike other viruses, including members families Circoviridae , Nanoviridae Geminiviridae . BoSCV also genetically similar to ChimpSCV,...
The bat paramyxovirus B16-40 was first isolated in Korea this study. Using the virus, we could obtain not only genomic information, but also several biological characteristics of virus. In phylogenetic analysis, virus found to belong recently proposed genus Shaanvirus. Through sequence analyses and vitro testing, have haemagglutinin-neuraminidase (HN) protein as one structural proteins. When mouse antiserum generated against tested, it cross-reactive human parainfluenza 1 an indirect...
Since the first emergence of SARS-CoV-2 variant in late 2020, novel variants have been continuously introduced to human population, causing severe public health threats. In general, because these acquire new genetic mutation/s, it is critical analyze biological function viruses that such mutations can confer.
Active serologic surveillance is necessary to control the spread of avian influenza virus (AIV).In this study, we evaluated a commercially-available cELISA in terms its ability detect AIV antibodies sera 3,358 animals from twelve species.cELISA detected against reference H1-through H15-subtype strains without cross reactivity.Furthermore, was able produced following challenge H9N2 subtype chickens, or vaccination H9 H5 subtypes ducks and geese.Next, tested sensitivity specificity with...
We investigated the infectivity and transmissibility of human seasonal H3N2, pandemic (pdm) H1N1 (2009) B influenza viruses in dogs. Dogs inoculated with H3N2 pdm exhibited nasal shedding were seroconverted against viruses; this did not occur virus-inoculated Transmission virus between dogs was demonstrated by observing seroconversion naïve after contact The seroprevalence study offered evidence infection occurring since 2008. Furthermore, serological alone combination canine found serum...
Bovine coronavirus (BCoV) is a causative agent of respiratory and enteric diseases in cattle calves. BCoV infection was also evident captive wild ruminants. Recently, water deer are recognized as the most common wildlife to approach farmhouses livestock barns Korea. Therefore, we investigated 77 nasal swab samples from non-captive (Hydropotes inermis) between November 2016 September 2017 identified three positive for coronavirus, indicating potential shedding. The full genomic sequences were...
Abstract Point-of-care tests (POCT) for pathogens are considered important low-resource countries and facilities. Although lateral flow immunoassays (LFIA) have many advantages including speed ease of use, their sensitivity is limited without specific equipment. Furthermore, response cannot be enhanced through enzymatic reactions. Owing to these limitations, LFIAs not yet been generally adopted as the standard protocol in vitro analysis infectious pathogens. We aimed develop a novel...
The ongoing coronavirus disease 2019 (COVID-19) pandemic and its overlap with the influenza season lead to concerns over severe caused by virus acute respiratory syndrome 2 (SARS-CoV-2) co-infections. Using a Syrian hamster co-infection model, SARS-CoV-2 A/California/04/2009 (H1N1), we found (a) more in co-infected animals compared those infected alone but not infection alone; (b) altered hematological changes only animals; (c) tropism tracts of animals. Overall, our study revealed that is...
Bats harbour diverse coronaviruses (CoVs), some of which are associated with zoonotic infections, as well inter-species transmission. In this study, a total 512 bat faecal samples from the habitats at different geographical locations in South Korea were investigated between 2016 and 2019. Seventy-eight positive for (15.2%), comprising 68 alphacoronaviruses (13.3%) 10 betacoronaviruses (2.0%). The rates tended to increase during awakening (April) period. Notably, only found site where...
The 23 open reading frame (ORF) 5 sequences of Korean type II porcine reproductive and respiratory syndrome virus (PRRSV) were collected from viremic sera the (modified live vaccine) MLV-vaccinating non-vaccinating farms 2007 to 2008.The samples phylogenetically analyzed with previous ORF5 sequences, including I PRRSV, previously reported or 1997 2008.A MN184-like subgroup PRRSV was newly identified in 2008.And PRRSVs, one had 87.2∼88.9%similarity Lelystad virus, showing a close relationship...