A5043530376- Neurogenetic and Muscular Disorders Research
- RNA modifications and cancer
- Nerve injury and regeneration
- Influenza Virus Research Studies
- Pain Mechanisms and Treatments
- RNA Research and Splicing
- Neuropeptides and Animal Physiology
- Nuclear Structure and Function
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Genetic Neurodegenerative Diseases
- Intraperitoneal and Appendiceal Malignancies
- Neuroscience and Neural Engineering
- Cardiac Structural Anomalies and Repair
- Muscle Physiology and Disorders
- Appendicitis Diagnosis and Management
- Cellular Mechanics and Interactions
- Magnetic Properties and Synthesis of Ferrites
- Hormonal and reproductive studies
- Biotin and Related Studies
- Amyotrophic Lateral Sclerosis Research
- COVID-19 epidemiological studies
- Health and Wellbeing Research
- RNA Interference and Gene Delivery
- Cholinesterase and Neurodegenerative Diseases
Columbia University Irving Medical Center
2014-2024
Korea University
2012-2020
Seoul National University
2010-2017
New Generation University College
2010-2016
National Medical Center
2016
Catholic University of Korea
2011-2013
St. Jude Children's Research Hospital
2010
D.I. Ivanovsky Institute of Virology Russian Academy of Medical Sciences
2010
Chungbuk National University
2010
Chungnam National University
2010
Abstract The distinct spatial architecture of the apical actin cables (or cap) facilitates rapid biophysical signaling between extracellular mechanical stimuli and intracellular responses, including nuclear shaping, cytoskeletal remodeling, mechanotransduction external forces into biochemical signals. These functions are abrogated in lamin A/C-deficient mouse embryonic fibroblasts that recapitulate defective organization laminopathies, featuring disruption cap. However, how A/C mediates...
Paucity of the survival motor neuron (SMN) protein triggers oft-fatal infantile-onset disorder, spinal muscular atrophy (SMA). Augmenting is one means treating SMA and recently led to FDA approval an intrathecally delivered SMN-enhancing oligonucleotide currently in use. Notwithstanding advent this other therapies for SMA, it unclear whether paralysis associated with disease derives solely from dysfunctional neurons that may be efficiently targeted by restricted delivery agents nervous...
Abstract A novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period operation offers unprecedented opportunities for medical implants, environmental sensors, and other applications. Here, we describe biodegradable, flexible silicon-based electronic system detects NO species with record-breaking sensitivity 136 Rs (5 ppm, 2 ) 100-fold selectivity over substances fast response (~30 s) recovery (~60 s). The exceptional...
Spinal muscular atrophy (SMA) is a common and often fatal neuromuscular disorder caused by low levels of the Survival Motor Neuron (SMN) protein. Amongst earliest detectable consequences SMN deficiency are profound defects junctions (NMJs). In model mice these synapses appear disorganized, fail to mature characterized poorly arborized nerve terminals. Given one role protein in orchestrating assembly spliceosomal snRNP particles subsequently regulating alternative splicing pre-mRNAs,...
Cholinergic dysfunction is strongly implicated in dystonia pathophysiology. Previously (Pappas et al., 2015;4:e08352), we reported that Dlx5/6-Cre mediated forebrain deletion of the DYT1 protein torsinA (Dlx-CKO) causes abnormal twisting and selective degeneration dorsal striatal cholinergic interneurons (ChI) 2015). A central question raised by work whether ChI loss cell autonomous or requires from neurons synaptically connected to ChIs. Here, addressed this using ChAT-Cre mice...
WE examined changes in expression of genes coding for α2-AR subtypes the dorsal root ganglion (DRG) a rat model (spinal nerve ligation) neuropathic pain. The present study demonstrates that majority DRG neurons express α2 C-AR mRNA and small proportion A-AR mRNA, while few B-AR non-operated animals. In addition, Cand A levels showed significant decrease increase, respectively ligated These findings suggest Aand C-ARs may play an important role generating sympathetically maintained
Management strategy in acute appendicitis patients initially presenting with abscess or mass is surrounded controversy. This study was performed to identify the outcomes of management for this condition.We retrospectively analyzed prospectively registered 76 (male:female = 39:37; mean age, 50.8 years) over a 9-year period at Seoul National University Hospital. Patients were divided into three groups (emergency operation group, delayed and follow-up group), clinical characteristics treatment...
Background The emergence of zoonotic viruses in domestic animals is a significant public health concern. Canine influenza virus (CIV) H3N2 that can infect companion and is, therefore, potential Objective This study investigated the inter- intraspecies transmission CIV among dogs, cats, ferrets, under laboratory conditions, to determine whether was possible between as well within these animal species. Method routes for were airborne direct contact, respectively. Transmission conducted through...
PERIPHERAL inflammation induces an increased brain-derived neurotrophic factor (BDNF) synthesis in the dorsal root ganglion (DRG) and elevated antero-grade transport of BDNF to axon terminals spinal horn. To characterize whether expression trkB is modulated response elevation these areas, we evaluated changes full-length truncated (trkB.FL trkB.T) mRNAs after injection complete Freund's adjuvant into hind paw rat. Reverse transcription-polymerase chain reaction analysis revealed that trkB.T...
We demonstrate that the novel pandemic influenza (H1N1) viruses have human virus-like receptor specificity and can no longer replicate in aquatic waterfowl, their historic natural reservoir. The biological properties of these are consistent with those phylogenetic progenitors, indicating longstanding adaptation to mammals.
Homozygous mutations in the aromatic l-amino acid decarboxylase (AADC) gene result a severe depletion of its namesake protein, triggering debilitating and often fatal form infantile Parkinsonism known as AADC deficiency. deficient patients fail to produce normal levels monoamine neurotransmitters dopamine serotonin, suffer multi-systemic disorder characterized by movement abnormalities, developmental delay autonomic dysfunction; an absolute loss is generally considered incompatible with...
This study prospectively investigated the effects of biofeedback therapy on objective anorectal function and subjective bowel in patients after sphincter-saving surgery for rectal cancer.Sixteen who underwent an ileostomy were randomized into two groups, one receiving conservative management with Kegel maneuver other active before closure. Among them, 12 (mean age, 57.5 years; range, 38 to 69 6 each group) completed study. Conservative included lifestyle modifications, exercises, medication....
Infantile-onset spinal muscular atrophy (SMA) is a prototypical disease in which to investigate selective neurodegenerative phenotypes. Caused by low levels of the ubiquitously expressed Survival Motor Neuron (SMN) protein, mainly targets motor neurons. This phenotype remains largely unexplained, but has not hindered development SMN repletion as means treatment. Here we chronicle recent advances area SMA biology. We provide brief background disease, highlight major that have shaped our...
The avian origin canine influenza virus H3N2 has been recently isolated and found to be currently in dog population South Korea China. purpose of this study was clarify the relationship between immunosuppressive glucocorticoids used veterinary clinical practice viral shedding pattern dogs.Eight conventional beagle dogs were divided into control infection group immunocompromised group. Dogs both groups infected with (2×10(6.0) EID50/0.1 mL). given orally 3.0 mg/kg prednisolone for 7 days....
Aging is a progressive functional decline in organs and tissues over time typically represents the accumulation of psychological social changes human being. Diverse diseases, such as cardiovascular, musculoskeletal, neurodegenerative disorders, are now understood to be caused by aging. While biological assessment aging mainly focuses on gradual that occur either molecular scale, for example, alteration gene expression epigenetic modification, or larger scales, muscle strength cardiac...