A5082857415- Cellular Mechanics and Interactions
- Nuclear Structure and Function
- Immune cells in cancer
- 3D Printing in Biomedical Research
- Skin and Cellular Biology Research
- Microtubule and mitosis dynamics
- RNA Interference and Gene Delivery
- Nanoplatforms for cancer theranostics
- Cell Adhesion Molecules Research
- Force Microscopy Techniques and Applications
- RNA Research and Splicing
- Cancer Cells and Metastasis
- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Graphene and Nanomaterials Applications
- Phagocytosis and Immune Regulation
- Extracellular vesicles in disease
- Epigenetics and DNA Methylation
- Biotin and Related Studies
- Conducting polymers and applications
- Pancreatic function and diabetes
- Advanced Sensor and Energy Harvesting Materials
- Nerve injury and regeneration
Korea University
2016-2025
Korea Institute of Science and Technology
2022-2025
Korean Association Of Science and Technology Studies
2022-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2018
PRG S&Tech (South Korea)
2017
Johns Hopkins University
2010-2016
Sidney Kimmel Comprehensive Cancer Center
2016
Harvard University
2015-2016
University of Baltimore
2013
Physical Sciences (United States)
2013
Focal adhesions are large protein complexes organized at the basal surface of cells, which physically connect extracellular matrix to cytoskeleton and have long been speculated mediate cell migration. However, whether clustering these molecular components into focal is actually required for proteins regulate motility unclear. Here we use quantitative microscopy characterize descriptors adhesion mouse embryonic fibroblasts human fibrosarcoma across a wide range compliance following genetic...
Abstract The distinct spatial architecture of the apical actin cables (or cap) facilitates rapid biophysical signaling between extracellular mechanical stimuli and intracellular responses, including nuclear shaping, cytoskeletal remodeling, mechanotransduction external forces into biochemical signals. These functions are abrogated in lamin A/C-deficient mouse embryonic fibroblasts that recapitulate defective organization laminopathies, featuring disruption cap. However, how A/C mediates...
Alterations in nuclear morphology are closely associated with essential cell functions, such as motility and polarization, correlate a wide range of human diseases, including cancer, muscular dystrophy, dilated cardiomyopathy, progeria. However, the mechanics forces that shape nucleus not well understood. Here, we demonstrate when an adherent is detached from its substratum, undergoes large volumetric reduction accompanied by morphological transition almost smooth to heavily folded surface....
Although eukaryotic cells are known to alternate between “advancing” episodes of fast and persistent movement “hesitation” low speed persistence, the molecular mechanism that controls dynamic changes in morphology, speed, persistence migratory remains unclear. Here, we show interphase nucleus during random cell migration switches intermittently two distinct modes - rotation translocation follow with high fidelity sequential rounded elongated morphologies body, respectively. Nuclear...
Cardiovascular disease (CVD) has emerged as a severe illness worldwide. Currently, the top ten causes of death in world include ischemic heart according to Global Health Observatory data provided by World Organization (WHO). To treat CVD, percutaneous coronary intervention (PCI) been used clinical treatment. Unfortunately, CVD is still considered serious for human health, even though mortality due reduced compared time before availability PCI procedure. Since implantation bare-metal stent...
Asterias pectinifera, a starfish that has been known to ruin the aquaculture industry owing its voracious appetite, recently identified as an eco-friendly source of non-toxic and highly water-soluble low-molecular weight collagen peptides, which promotes wound healing, bone regeneration, skin protection. Although they have potential applications in biomedical applications, including pharmaceuticals cosmetic products, it remains unclear how improve vivo absorption peptides. Here, we present...
The perinuclear actin cap (or cap) is a recently characterized cytoskeletal organelle composed of thick, parallel, and highly contractile acto-myosin filaments that are specifically anchored to the apical surface interphase nucleus. present in wide range adherent eukaryotic cells, but disrupted several human diseases, including laminopathies cancer. Through its large terminating focal adhesions anchorage nuclear lamina envelope through LINC complexes, plays critical role both...
Abstract A novel transient electronics technology that is capable of completely dissolving or decomposing in certain conditions after a period operation offers unprecedented opportunities for medical implants, environmental sensors, and other applications. Here, we describe biodegradable, flexible silicon-based electronic system detects NO species with record-breaking sensitivity 136 Rs (5 ppm, 2 ) 100-fold selectivity over substances fast response (~30 s) recovery (~60 s). The exceptional...
Mechanical properties of the tumor microenvironment play a critical role in cancer progression by activation mechano-responses. The biophysical interactions between cells and their dynamic are attributed to force-dependent alterations molecular pathways that trigger structural reorganization intracellular organelles associated genetic modifications. Recent studies underscore oxygen concentration metastasis. Suppressed levels promote development invasive phenotypes aggressive proliferation...
We recently demonstrated the existence of a previously uncharacterized subset actomyosin fibers that form perinuclear actin cap, cytoskeletal structure tightly wraps around nucleus wide range somatic cells. Fibers in cap are distinct from well-characterized, conventional at basal and cortical surfaces adherent cells their subcellular location, internal organization, dynamics, ability to generate contractile forces, response pharmacological treatments, biochemical stimuli, regulation by...
The cellular microenvironment plays an important role in regulating cancer progress. Cancer can physically and chemically remodel its surrounding extracellular matrix (ECM). Critical behaviors such as recognition of geometry rigidity, cell polarization motility, cytoskeletal reorganization, proliferation be changed a consequence these ECM alternations. Here, we present overview mechanobiology detail, focusing on microenvironmental sensing exogenous cues quantification cancer–substrate...
Abstract Developing materials with the capability of changing their innate features can help to unravel direct interactions between cells and ligand‐displaying features. This study demonstrates grafting magnetic nanohelices displaying cell‐adhesive Arg‐Gly‐Asp (RGD) ligand partly a material surface. These enable nanoscale control rapid winding (“W”) unwinding (“UW”) nongrafted portion, such as directional changes in nanohelix (lower, middle, upper directions) by position permanent magnet...
Abstract Native extracellular matrix (ECM) exhibits dynamic change in the ligand position. Herein, ECM‐emulating control and real‐time monitoring of stem cell differentiation are demonstrated by nanoassembly. The density gold nanoassembly presenting cell‐adhesive Arg‐Gly‐Asp (RGD) on Fe 3 O 4 (magnetite) nanoparticle nanostructures flexibly grafted to material is changed while keeping macroscale invariant. can be magnetically attracted mediate rising falling movements via linker stretching...
Abstract Photodynamic therapy shows promise for glioma treatment with powerful efficacy and low resistance, however, its effectiveness is significantly lowered by inadequate light delivery through the skull. Herein, a needle‐type implantable microLED device cathepsin B‐responsive prodrug nanoparticles (PNPs) are newly exploited glioma's chemo‐photodynamic combination therapy. The containing four small LEDs on tip of guide needle can be implanted into center tissues without large area opening...
The engineered three-dimensional (3D) cell cultivation system for the production of multicellular spheroids has attracted considerable attention due to its improved in vivo relevance cellular communications compared with traditional two-dimensional (2D) culture platform. formation and maintenance a healthy condition is critical factor tissue engineering applications such as repair damaged tissues, development organ replacement parts preclinical drug tests. However, culturing conventional...
The objective of this study was to develop small-diameter vascular grafts capable eluting SDF (stromal cell-derived factor)-1α-derived peptide and SP (substance P) for in situ regeneration.Polycaprolactone (PCL)/collagen containing or SDF-1α-derived were fabricated by electrospinning. SDF-1α peptide-loaded recruited significantly higher numbers mesenchymal stem cells than that the control group. vivo potential PCL/collagen, SDF-1, assessed implanting them a rat abdominal aorta up 4 weeks....