A5078898813- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal and Macular Surgery
- Osteoarthritis Treatment and Mechanisms
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Ocular Surface and Contact Lens
- Molecular Junctions and Nanostructures
- 2D Materials and Applications
- Cancer, Hypoxia, and Metabolism
- Advanced Chemical Physics Studies
- Herpesvirus Infections and Treatments
- Semiconductor materials and devices
- Peroxisome Proliferator-Activated Receptors
- Retinal and Optic Conditions
- Ocular Infections and Treatments
- Advanced Glycation End Products research
- Retinal Development and Disorders
- Laser-induced spectroscopy and plasma
- Immune cells in cancer
- MicroRNA in disease regulation
- Connexins and lens biology
- Fibroblast Growth Factor Research
- Ocular Diseases and Behçet’s Syndrome
Tianjin Medical University Eye Hospital
2016-2025
Tianjin Medical University
2016-2025
Beijing Sport University
2024-2025
Third Affiliated Hospital of Southern Medical University
2013-2024
National Clinical Research
2024
New York University
2024
Tibetan Traditional Medical College
2024
National University of Singapore
2005-2023
Key Laboratory of Guangdong Province
2021-2023
Army Medical University
2020-2022
Objectives To investigate the roles and regulatory mechanisms of synovial macrophages their polarisation in development osteoarthritis (OA). Methods Synovial tissues from normal patients with OA were collected. M1 or M2-polarised mice analysed by immunofluorescence immunohistochemical staining. Mice tuberous sclerosis complex 1 (TSC1) Rheb deletion specifically myeloid lineage generated subjected to intra-articular injection collagenase (collagenase-induced osteoarthritis, CIOA)...
To investigate the role of mechanical stress in cartilage ageing and identify mechanistic association during osteoarthritis (OA) progression.F-box WD repeat domain containing 7 (FBXW7) ubiquitin ligase expression chondrocyte senescence were examined vitro, experimental OA mice human cartilage. Mice with Fbxw7 knockout chondrocytes generated adenovirus-expressing (AAV-Fbxw7) was injected intra-articularly mice. Destabilised medial meniscus surgery performed to induce OA. Cartilage damage...
Molecularly soft organic-inorganic hybrid perovskites are susceptible to dynamic instabilities of the lattice called octahedral tilt, which directly impacts their carrier transport and exciton-phonon coupling. Although structural phase transitions associated with tilt has been extensively studied in 3D halide perovskites, its impact 2D is not well understood. Here, we used scanning tunneling microscopy (STM) visualize surface freshly exfoliated Ruddlesden-Popper (RPPs) across homologous...
Tendon-bone interface injuries pose a significant challenge in tissue regeneration, necessitating innovative approaches. Hydrogels with integrated supportive features and controlled release of therapeutic agents have emerged as promising candidates for the treatment such injuries. In this study, we aimed to develop temperature-sensitive composite hydrogel capable providing sustained magnesium ions (Mg2+). We synthesized magnesium-Procyanidin coordinated metal polyphenol nanoparticles (Mg-PC)...
Fenofibrate is a peroxisome proliferator-activated receptor α (PPARα) agonist and has been shown to have therapeutic effects on diabetic retinopathy (DR). However, the of fenofibrate through systemic administration are not as potent desired due inefficient drug delivery retina. The present study aimed explore sustained fenofibrate-loaded biodegradable nanoparticles (NP) both DR neovascular age-related macular degeneration (AMD). was successfully encapsulated into poly(lactic-co-glycolic...
It is generally thought that the occurrence and progression of osteoarthritis (OA) results from multiple causes, including degradation destruction cartilage matrix aging chondrocytes. Metformin a first-line drug for treatment diabetes, has great potential other disorders. However, role metformin in OA unknown.Metformin displayed protective effect against OA. There were lower OARSI scores fewer MMP-13-positive cells DMM mice explants after with metformin. In addition, decreased p16INK4a...
Increasing evidences show that aberrant subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). However, how formation is activated and mechanism by which increased turnover promotes cartilage degeneration during OA remains unclear. Here, we mechanistic target rapamycin complex 1 (mTORC1) pathway preosteoblasts (Osterix+) from patients mice. Constitutive activation mTORC1 deletion upstream inhibitor, tuberous sclerosis 1, induced formation, with...
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), novel adipokine regulates inflammation and angiogenesis, has been extensively studied variety organs diseases. However, effect FABP4 on RA remains unclear. Here, we found expression was upregulated synovial M1-polarized macrophages RA. The increase promoted synovitis, cartilage degradation to exacerbate progression vivo vitro, whereas BMS309403 (a...
Two-dimensional (2D) organic-inorganic hybrid perovskites have attracted intense interests due to their quantum well structure and tunable excitonic properties. As an alternative the well-studied divalent metal perovskite based on Pb2+, Sn2+ Cu2+, trivalent metal-based (eg. Sb3+ with ns2 outer-shell electronic configuration) A3M2X9 formula (A = monovalent cations, M metal, X halide) offer intriguing possibilities for engineering ferroic Here, we synthesized 2D ferroelectric (TMA)3Sb2Cl9...
Abstract Emerging evidence has shown an imbalance in M1/M2 macrophage polarization to play essential role osteoarthritis (OA) progression. However, the underlying mechanistic basis for this is unknown. RNA sequencing of OA M1-polarized macrophages found highly expressed levels pentraxin 3 (PTX3), suggesting a PTX3 occurrence and development. Herein, was be increased synovium articular cartilage patients mice. Intra-articular injection aggravated, while neutralization reversed synovitis...
2D materials with ferroelectric and piezoelectric properties are of interest for energy harvesting, memory storage electromechanical systems. Here, we present a systematic study the in NbOX2 (X = Cl, I) across different spatial scales. The in-plane ferroelectricity was investigated using transport piezoresponse force microscopy (PFM) measurements, where it observed that NbOCl2 has stronger order than NbOI2. A high local field, exerted by both PFM scanning tunneling (STM) tips, found to...
Abstract Vitamin D3 upregulated protein 1 (VDUP1) is a candidate tumor suppressor, the expression of which dramatically reduced in various tissues. In this study, we found that VDUP1 suppressed during human hepatic carcinogenesis, and mice lacking are much more susceptible to diethylnitrosamine-induced hepatocarcinogenesis compared with wild type mice. VDUP1-deficient tumors proliferated significantly than had corresponding changes key cell cycle regulatory proteins. addition,...
PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role early OA progression has not been investigated yet. Here, a mouse destabilization model the tibia was used to investigate roles subchondral bone changes and pathological process. We revealed significant increase activation which associated with aberrant formation tibial following destabilizing medial meniscus (DMM), effectively prevented by treatment inhibitor...
Vascular-invasion-mediated interactions between activated articular chondrocytes and subchondral bone are essential for osteoarthritis (OA) development. Here, we determined the role of nutrient sensing mechanistic target rapamycin complex 1 (mTORC1) signaling in crosstalk across cartilage interface its regulatory mechanisms. Then mice with chondrocyte-specific mTORC1 activation (Tsc1 CKO Tsc1 CKOER ) or inhibition (Raptor their littermate controls were subjected to OA induced by...
Abstract Quasi-two-dimensional perovskites have emerged as a new material platform for optoelectronics on account of its intrinsic stability. A major bottleneck to device performance is the high charge injection barrier caused by organic molecular layers basal plane, thus best performing currently relies edge contact. Herein, leveraging van der Waals coupling and energy level matching between two-dimensional Ruddlesden-Popper perovskite graphene, we show that plane-contacted graphene...
Milk fat globule-epidermal growth factor (EGF) 8 (MFG-E8), as a necessary bridging molecule between apoptotic cells and phagocytic cells, has been widely studied in various organs diseases, while the effect of MFG-E8 osteoarthritis (OA) remains unclear. Here, we identified key mediating chondrocyte senescence macrophage polarization revealed its role pathology OA. We found that expression was downregulated both locally systemically OA advanced patients with mice after destabilization medial...
Liquid-phase exfoliation can be developed for the large-scale production of two-dimensional materials photonic applications. Although atomically thin 2D transition metal dichalcogenides (TMDs) show enhanced nonlinear optical properties or photoluminescence quantum yield relative to bulk phase, these are weak in absolute sense due ultrashort path, and they also sensitive layer-dependent symmetry properties. Another practical issue is that chemical stability some TMDs (e.g., Weyl semimetals)...
The purpose of this study was to explore the role microRNA-451a (miR-451a) in diabetic retinopathy through activating transcription factor 2 (ATF2). epiretinal membrane samples from patients with proliferative (PDR) were immunolabeled an antibody for Ki-67 identify cells. expression miR-451a measured by qRT-PCR retina Akita mice and RPE cells under conditions. potential downstream targets predicted bioinformatics confirmed dual luciferase assay, qRT-PCR, Western blotting. Mitochondrial...
Abstract Background Intervertebral disc degeneration is a major cause of chronic low back pain, and excessive loading contributes to intervertebral degeneration. However, the lack an effective bipedal in vivo animal model limits research about this condition. Questions/purposes To evaluate utility new type standing mouse for degeneration, we asked: (1) Are there spinal changes mice as determined by lumbar height, histologic features, immunohistochemistry measures compared with control mice?...