A5023477612- Osteoarthritis Treatment and Mechanisms
- Rheumatoid Arthritis Research and Therapies
- Cancer-related molecular mechanisms research
- Signaling Pathways in Disease
- Immune cells in cancer
- Peroxisome Proliferator-Activated Receptors
- Venous Thromboembolism Diagnosis and Management
- interferon and immune responses
- RNA modifications and cancer
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Bone and Joint Diseases
- Biomarkers in Disease Mechanisms
- Musculoskeletal synovial abnormalities and treatments
- Adipose Tissue and Metabolism
- Myofascial pain diagnosis and treatment
- Selenium in Biological Systems
- RNA Interference and Gene Delivery
- Traditional Chinese Medicine Analysis
- Shoulder Injury and Treatment
- Laser Applications in Dentistry and Medicine
- Gout, Hyperuricemia, Uric Acid
- Astronomy and Astrophysical Research
- Additive Manufacturing Materials and Processes
- MicroRNA in disease regulation
Zhujiang Hospital
2020-2025
Southern Medical University
2020-2025
Third Affiliated Hospital of Southern Medical University
2018-2024
Key Laboratory of Guangdong Province
2023
Southern University of Science and Technology
2022
Guangdong Province Stomatological Hospital
2018-2019
Guangdong Academy of Medical Sciences
2018
It is generally thought that the occurrence and progression of osteoarthritis (OA) results from multiple causes, including degradation destruction cartilage matrix aging chondrocytes. Metformin a first-line drug for treatment diabetes, has great potential other disorders. However, role metformin in OA unknown.Metformin displayed protective effect against OA. There were lower OARSI scores fewer MMP-13-positive cells DMM mice explants after with metformin. In addition, decreased p16INK4a...
Increasing evidence shows that adipokines play a vital role in the development of rheumatoid arthritis (RA). Fatty acid-binding protein 4 (FABP4), novel adipokine regulates inflammation and angiogenesis, has been extensively studied variety organs diseases. However, effect FABP4 on RA remains unclear. Here, we found expression was upregulated synovial M1-polarized macrophages RA. The increase promoted synovitis, cartilage degradation to exacerbate progression vivo vitro, whereas BMS309403 (a...
Obesity has always been considered a significant risk factor in osteoarthritis (OA) progression, but the underlying mechanism of obesity-related inflammation OA synovitis remains unclear. The present study found that synovial macrophages infiltrated and polarized obesity microenvironment identified essential role M1 impaired macrophage efferocytosis using pathology analysis obesity-associated OA. revealed obese patients Apoe-/- mice showed more pronounced enhanced infiltration tissue,...
In rheumatoid arthritis (RA), a debilitating autoimmune disorder marked by chronic synovial inflammation and progressive cartilage degradation, fibroblast-like synoviocytes (FLS) are key pathogenic players.Current treatments targeting these cells limited.Our study focused on the Fat Mass Obesity-associated protein (FTO), known for its roles in cell proliferation inflammatory response modulation, involvement RA.We specifically examined regulatory of FTO CMPK2, mitochondrial DNA synthesis...
PI3K/AKT signaling is essential in regulating pathophysiology of osteoarthritis (OA). However, its potential modulatory role early OA progression has not been investigated yet. Here, a mouse destabilization model the tibia was used to investigate roles subchondral bone changes and pathological process. We revealed significant increase activation which associated with aberrant formation tibial following destabilizing medial meniscus (DMM), effectively prevented by treatment inhibitor...
Abstract Mechanical overloading and aging are two essential factors for osteoarthritis (OA) development. Mitochondria have been identified as a mechano-transducer situated between extracellular mechanical signals chondrocyte biology, but their roles the associated mechanisms in stress-associated senescence OA not elucidated. Herein, we found that PDZ domain containing 1 (PDZK1), one of proteins, which belongs to Na + /H Exchanger (NHE) regulatory factor family, is key biomechanically induced...
Long-term use of disease-modifying anti-rheumatic drugs (DMARDs) such as methotrexate (MTX) shows clinical benefits for rheumatoid arthritis (RA) treatment. However, there are growing concerns over the adverse effects systemic drug administration. Therefore, a strategy that can enhance bioavailability while minimizing side is urgently needed, but remains challenge in RA therapy. To this end, here we conjugated MTX with supramolecular self-assembling hydrogel composed d-amino acids sequence...
Rheumatoid arthritis (RA) is a common chronic inflammatory disease characterized by the proliferation of fibroblast-like synoviocytes (FLS), pannus development, cartilage, and bone degradation, and, eventually, loss joint function. Fibroblast activating protein (FAP) particular product activated FLS highly prevalent in RA-derived (RA-FLS). In this study, zinc ferrite nanoparticles (ZF-NPs) were engineered to target FAP
This study aimed to investigate the role and regulatory mechanisms of Ezrin in synovial vessels rheumatoid arthritis (RA). Synovial tissues were obtained from people with osteoarthritis patients RA patients. We also used an antigen-induced (AIA) mice model by using Freund's adjuvant injections. expression was analysed immunofluorescence immunohistochemical staining AIA mice. investigated on vascular endothelial cells its mechanism vivo vitro adenoviral transfection technology. Our results...
Osteosarcoma (OS) often occurs in children and undergoes metastasis, resulting lower survival rates. Information on the complexity pathogenic mechanism of OS is limited, thus, development treatments involving alternative molecular genetic targets hampered. We categorized transcriptome data into metastasis nonmetastasis groups, 400 differential RNAs (230 messenger (mRNAs) 170 long noncoding (lncRNAs)) were obtained by edgeR package. Prognostic genes identified performing univariate Cox...
Diffuse pigmented villonodular synovitis (PVNS) is prone to recurrence after surgery, and it difficult achieve a long-term complete cure.To reduce the rate of PVNS, author pioneered arthroscopic total synovial peel (ATSP).From March 2014 July 2020, 19 patients (6 males 13 females) with diffuse PVNS knee were treated in our department underwent ATSP. It's 'peel' rather than simple excision. This method similar peeling bark. Relapse rates functional scores determined, follow-ups ranging from...
Abstract Background The aggressive phenotype of fibroblast-like synoviocytes (FLS) has been identified as a contributing factor to the exacerbation rheumatoid arthritis (RA) through promotion synovitis and cartilage damage. Regrettably, there is currently no effective therapeutic intervention available address this issue. Recent research shed light on crucial regulatory role R-spondin-2 (Rspo2) in cellular proliferation, degradation, tumorigenesis. However, specific impact Rspo2 RA remains...
Osteosarcoma is a highly malignant disease and associated with poor patient prognosis high mortality rate. Disease significantly correlates chemotherapeutic responses. Cadmium heavy metal specific effects on bone, but its benefits for osteosarcoma treatment have not been characterized. In the present study, cadmium chloride was used to treat MG63 cells, their gene expression profiles were assessed by GeneChip technology. We found that forkhead box protein M1 (FOXM1) downregulated chloride,...