A5069152432- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- interferon and immune responses
- Cancer-related gene regulation
- RNA Research and Splicing
- Osteoarthritis Treatment and Mechanisms
- Hippo pathway signaling and YAP/TAZ
- Inflammatory mediators and NSAID effects
- Inflammasome and immune disorders
- Bone Metabolism and Diseases
- Toxoplasma gondii Research Studies
- Natural product bioactivities and synthesis
- Antiplatelet Therapy and Cardiovascular Diseases
- Liver Disease and Transplantation
- Angiogenesis and VEGF in Cancer
- PI3K/AKT/mTOR signaling in cancer
- Biological Activity of Diterpenoids and Biflavonoids
- Xenotransplantation and immune response
- Peroxisome Proliferator-Activated Receptors
- Viral Infections and Vectors
- Advanced Glycation End Products research
- Drug-Induced Hepatotoxicity and Protection
- Clinical Nutrition and Gastroenterology
- Research on Leishmaniasis Studies
Southern Medical University
2018-2025
Third Affiliated Hospital of Southern Medical University
2016-2025
Texas A&M University
2024
Southern University of Science and Technology
2024
Yue Bei People's Hospital
2024
Shantou University
2024
Broad Institute
2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Tianjin Medical University
2023
Objectives To investigate the roles and regulatory mechanisms of synovial macrophages their polarisation in development osteoarthritis (OA). Methods Synovial tissues from normal patients with OA were collected. M1 or M2-polarised mice analysed by immunofluorescence immunohistochemical staining. Mice tuberous sclerosis complex 1 (TSC1) Rheb deletion specifically myeloid lineage generated subjected to intra-articular injection collagenase (collagenase-induced osteoarthritis, CIOA)...
Communication between osteoblasts and endothelial cells (ECs) is essential for bone turnover, but the molecular mechanisms of such communication are not well defined. Here we identify Cxcl9 as an angiostatic factor secreted by in marrow microenvironment. We show that produced interacts with vascular growth prevents its binding to ECs osteoblasts, thus abrogating angiogenesis osteogenesis both mouse vitro. The mechanistic target rapamycin complex 1 activates expression transcriptional...
Abstract Background To investigate the role and regulatory mechanisms of fargesin, one main components Magnolia fargesii , in macrophage reprogramming crosstalk across cartilage synovium during osteoarthritis (OA) development. Methods Ten-week-old male C57BL/6 mice were randomized assigned to vehicle, collagenase-induced OA (CIOA), or CIOA with intra-articular fargesin treatment groups. Articular degeneration was evaluated using Osteoarthritis Research Society International (OARSI) score....
Inflammatory bowel disease (IBD) is a chronic and potentially life-threatening inflammatory of gastroenteric tissue characterized by episodes intestinal inflammation, but the underlying mechanisms remain elusive. Here, we explore role precise mechanism Van-Gogh-like 2 (VANGL2) during pathogenesis IBD. VANGL2 decreases in IBD patients dextran sulfate sodium (DSS)-induced colitis mice. Myeloid deficiency exacerbates progression DSS-induced mice specifically enhances activation NLRP3...
Vascular-invasion-mediated interactions between activated articular chondrocytes and subchondral bone are essential for osteoarthritis (OA) development. Here, we determined the role of nutrient sensing mechanistic target rapamycin complex 1 (mTORC1) signaling in crosstalk across cartilage interface its regulatory mechanisms. Then mice with chondrocyte-specific mTORC1 activation (Tsc1 CKO Tsc1 CKOER ) or inhibition (Raptor their littermate controls were subjected to OA induced by...
Macroautophagy/autophagy plays an important role in regulating cellular homeostasis and influences the pathogenesis of degenerative diseases. Tendinopathy is characterized by tendon degeneration inflammation. However, little known about selective autophagy tendinopathy. Here, we find that pristimerin (PM), a quinone methide triterpenoid, more effective treating tendinopathy than first-line drug indomethacin. PM inhibits AIM2 inflammasome alleviates inflammation during promoting autophagic...
Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator suppress IFN-I during vesicular stomatitis virus (VSV) infection. Mechanistically, VANGL2 interacted with TBK1 and promoted selective autophagic degradation via K48-linked polyubiquitination at Lys 372 by E3...
Innate immunity acts as the first line of defense against pathogen invasion. During Toxoplasma gondii infection, multiple innate immune sensors are activated by invading microbes or pathogen-associated molecular patterns (PAMPs). However, how inflammasome is and its regulatory mechanisms during T. infection remain elusive. Here, we showed that PRU, a lethal type II strain, activates at early stage infection. PRU tachyzoites, RNA soluble tachyzoite antigen (STAg) mainly triggered NLRP3...
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases are required to link pathogen DNA sensing immune responses. However, mechanisms by which cGAS-STING-induced cytokines suppress adaptive response malaria infections remain poorly understood. Here, cGAS-STING signaling is identified a detrimental role regulating anti-malaria immunity. cGAS or STING deficiency mice markedly prolongs mouse survival...
Abstract Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms regulation responsible pathogenesis still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration synovitis during OA. PAB, a diterpene acid, specifically inhibited NF‐κB signalling reduced production of pro‐inflammatory cytokines, which further decreased M1 vessel formation. We provide in vivo vitro...
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of The nuclear factor-kappaB (NF-κB) signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( ΔM ) are...
Background Intestinal transplantation (IT) has become an important procedure for the treatment of irreversible intestinal failure. However, IT is extremely vulnerable to ischemia–reperfusion injury (IRI). Due limitations static cold storage (SCS), hypothermic machine perfusion (HMP) rapidly gaining popularity. In this study, HMP system established and compared with SCS. Methods An was built. Ten miniature pigs were randomly divided into SCS groups, their intestines perfused using device SCS,...
Hepatic ischemia reperfusion injury (IRI) is a risk factor for early graft nonfunction and rejection after liver transplantation (LT). The process of IRI involves inflammatory response, oxidative stress, apoptosis other pathophysiological processes. So far, there still lack effective drugs to ameliorate IRI. Trans-anethole (TA) an aromatic compound. Many medications as well natural foods contain TA. TA has multiple effects such anti-inflammation, anti-oxidative stress anti-apoptosis....
Abstract Toxoplasma gondii ( T. )‐associated polymorphic effector proteins are crucial in parasite development and regulating host anti‐ immune responses. However, the mechanism remains obscure. Here, it is shown that dense granules 4 (GRA4) restricts IFN‐I activation. Infection with Δ gra4 mutant strain induces stronger responses poses a severe threat to health. Mechanistically, GRA4 binds phosphorylated TBK1 promote TRIM27‐catalyzed K48‐ubiquitination at Lys251/Lys372 residues, which...
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of The nuclear factor-kappaB (NF-κB) signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( ΔM ) are...
ABSTRACT Stringent control of the type I interferon (IFN-I) signaling is critical for host immune defense against infectious diseases, yet molecular mechanisms that regulate this pathway remain elusive. Here, we show Src homology 2 containing inositol phosphatase 1 (SHIP1) suppresses IFN-I by promoting IRF3 degradation during malaria infection. Genetic ablation Ship1 in mice leads to high levels and confers resistance Plasmodium yoelii nigeriensis ( P.y. ) N67 Mechanistically, SHIP1 promotes...
Van Gogh-like 2 (Vangl2), a core planar cell polarity (PCP) component, plays an important role in polarized cellular and tissue morphology induction, growth development cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of NF-κB signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( Δ M ) are hypersusceptible to...
Van Gogh-like 2 (Vangl2), a core planar cell polarity (PCP) component, plays an important role in polarized cellular and tissue morphology induction, growth development cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of NF-κB signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( Δ M ) are hypersusceptible to...
Type I interferon (IFN-I, IFN-α/β), precisely controlled by multiple regulators, including suppressor of cytokine signaling 1 (SOCS1), is critical for host defense against pathogens. However, the impact IFN-α/β on malaria parasite infections, beneficial or detrimental, remains controversial.