A5101417952- Medical Imaging Techniques and Applications
- Radiation Detection and Scintillator Technologies
- Advanced MRI Techniques and Applications
- Ion channel regulation and function
- Radiomics and Machine Learning in Medical Imaging
- Pulmonary Hypertension Research and Treatments
- MicroRNA in disease regulation
- Mosquito-borne diseases and control
- Neuroscience and Neuropharmacology Research
- Synthesis and properties of polymers
- Digital Radiography and Breast Imaging
- Infective Endocarditis Diagnosis and Management
- Diamond and Carbon-based Materials Research
- Immunotherapy and Immune Responses
- Atomic and Subatomic Physics Research
- Kawasaki Disease and Coronary Complications
- Epoxy Resin Curing Processes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Machine Learning in Materials Science
- Anesthesia and Sedative Agents
- interferon and immune responses
- Metal and Thin Film Mechanics
- Erythrocyte Function and Pathophysiology
- Anesthesia and Neurotoxicity Research
- Coronary Artery Anomalies
Huazhong University of Science and Technology
2007-2024
Sun Yat-sen University
2020-2024
Fudan University
2007-2024
The First Affiliated Hospital, Sun Yat-sen University
2020-2024
Zhongshan Hospital
2020-2024
Union Hospital
2018-2024
First Affiliated Hospital Zhejiang University
2022-2024
Southern Medical University
2020-2024
Union Hospital
2023-2024
Donghua University
2023-2024
The Ingenuity TF PET–MRI is a newly released whole-body hybrid PET–MR imaging system with Philips time-of-flight GEMINI PET and Achieva 3T X-series MRI system. Compared to PET–CT, modifications the positron emission tomography (PET) gantry were made avoid mutual interference deliver uncompromising performance which equivalent standalone systems. was redesigned introduce magnetic shielding for photomultiplier tubes (PMTs). Stringent electromagnetic noise requirements of MR necessitated...
With the support of advanced information and communication technologies open innovative design platforms, emerging blooming paradigm mass personalization drives process engineering to include knowledge with higher heterogeneity more complex modalities. To this end, Multi-Modal Knowledge Graphs (MMKG), evolved from semantic networks graphs, provide a powerful technology system for effectively organizing utilizing knowledge. understand state-of-the-art key aspects that enables MMKG, recognize...
In the field of wind power generation, turbines serve as foundation for harnessing electrical energy. However, assembly process information is typically dispersed among various modalities such 3D models, natural text, and images in form documents. The difficulty effectively utilising historical knowledge hampers efficiency design subsequently affects production efficiency. To address this issue, paper constructs a Multi-modal Process Knowledge Graph Wind Turbines, named MPKG-WT....
Philips has recently released the time-of-flight (TOF) PET/CT GEMINI-TF scanner. It uses 4 times 22 mm <sup xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</sup> LYSO crystals, which 600 ps timing resolution, 12% energy resolution and 4.8 spatial resolution. This paper describes system design general approach of TOF reconstruction in Philips' A relaxed list mode ordered subset expectation maximization (LMOSEM) algorithm is used reconstruction, with...
In this paper MR-based attenuation method was implemented for a clinical whole-body PET/MR system. While awaiting future evaluation, the algorithm seems promising from preliminary patient data both qualitative PET image quality and quantification accuracy. 3-segment MRAC resembles results short transmission scans, work will be to implement validate segmentation of more tissue classes, such as cortical bone. Robustness MR truncation compensation incorporation flexible coils need improved.
Different anesthetics exert different effects on the long-term outcomes of various cancers. The TWIK-related acid sensitive potassium 3 (TASK-3) channel is an important target and upregulated in However, role underlying mechanism TASK-3 ovarian cancer remain unknown. Here, we tested whether contributes to We found that was overexpressed human cell lines. Clinically relevant concentrations lidocaine, as a inhibitor, inhibitory tumor growth metastasis cells
Backgrounds/Aims: Intrahepatic cholangiocarcinoma (ICC) is a highly desmoplastic tumor with poor prognosis even after curative resection. We investigated the associations between composition of ICC stroma and immune cell infiltration aimed to develop stromal-immune signature predict in surgically treated ICC.Methods: recruited 359 patients performed immunohistochemistry detect α-smooth muscle actin (α-SMA), CD3, CD4, CD8, Foxp3, CD68, CD66b. Aniline was used stain collagen deposition....
Background . Inflammation and pain are closely related to humans’ animals’ health. Resveratrol (RSV) is a natural compound with various biological activities. The current study aimed evaluate the analgesic anti‐inflammatory activities of RSV in vivo Materials Methods effects were assessed by acetic acid‐induced writhing hot plate tests. determined using xylene‐induced mouse ear oedema, rat pleurisy, carrageenan‐induced synovitis tests, respectively. Results results showed that could...
Pro-resolving mediators (PRMs) are considered as emerging analgesics for chronic pain. Maresin 1 (MaR1) is a newly identified member of PRMs, and recent studies implicate its potential role in some pain conditions. As the function MaR1 neuropathic remains unclear, we investigated effects on hypersensitivity underlying mechanism using rat spinal nerve ligation (SNL) model pain.MaR1 (100 ng/10 μL) or commensurable artificial cerebrospinal fluid was delivered via intrathecal catheter from days...
Abstract A series of alternating polyamide–imides (PAIs) with fluorenyl cardo having inherent viscosities 0.38–0.88 dL/g was synthesized by one‐pot polycondensation diamines, trimellitic anhydride, and various aromatic diamines including p ‐phenylene diamine, m 4,4'‐oxydianiline, 3,4'‐oxydianiline, 2,2‐bis[4‐(4‐aminophenoxy)phenyl]propane, 2,2‐bis[4‐(3‐amino phenoxy)phenyl]propane using triphenyl phosphite as condensing agents. Most the polymers were readily soluble in a variety organic...
Plasmacytoid dendritic cells (pDCs) are present in various primary and metastatic human neoplasms; however, their clinical significance intrahepatic cholangiocarcinoma is not clear.To evaluate pDCs' distributions around tumors as well potential function predictive value for prognosis patients undergoing curative resection, we performed immunohistochemistry to examine the expression of pDC marker BDCA2, CD3, CD4, CD8 Foxp3 intratumoral peritumoral tissues from 359 with compared prognostic...
Infiltrating immune cells in the tumor microenvironment (TME) influence progression and patient prognosis, making them attractive therapeutic targets for immunotherapy research. A deeper understanding of cell distributions TME hepatocellular carcinoma (HCC) is needed to identify interactions among different types that might impact effectiveness potential immunotherapies. We performed multiplex immunohistochemistry using a tissue microarray samples from 302 patients with HCC elucidate spatial...
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) play critical roles in the innate immunity against infectious diseases are required to link pathogen DNA sensing immune responses. However, mechanisms by which cGAS-STING-induced cytokines suppress adaptive response malaria infections remain poorly understood. Here, cGAS-STING signaling is identified a detrimental role regulating anti-malaria immunity. cGAS or STING deficiency mice markedly prolongs mouse survival...
Abstract Novel fluorenyl cardo chain‐extended bismaleimides (FCCEBMIs) were synthesized by reacting maleic anhydride with diamine and different dianhydrides. FCCEBMIs characterized FT‐IR spectra (FT‐IR), 1 H NMR, elemental analysis. All FCCEBMI monomers readily soluble in a variety of organic solvents, such as N ‐methyl‐2‐pyrrolidinone, , ‐dimethyl acetamide, chloroform (CHCl 3 ), methylene chloride (CH 2 Cl dimethyl sulfoxide, tetrahydrofuran when compared 9,9‐bis(4‐maleimidophenyl)...
In positron emission tomography (PET) imaging, scattered gamma photons typically account for more than 30% of total detected coincidence counts. Single scatter simulation (SSS) method is widely used estimating contribution in PET image reconstruction. Monte Carlo (MC) techniques are accurate but computationally expensive. When using SSS, the modeled scaled to match measured data. Typically tail fitting this scaling. However, when available part either too small or noisy, technique may lead...
Abnormal pulmonary arterial vascular smooth muscle cells (PASMCs) proliferation is critical pathological feature of remodeling that acts as driving force in the initiation and development hypertension (PAH), ultimately leading to hypertension. Aloperine a main active alkaloid extracted from traditional Chinese herbal Sophora alopecuroides possesses outstanding antioxidation anti-inflammatory effects. Our group found has protective effects on monocroline-induced rats by inhibiting oxidative...
The emerging role of inflammation in the initiation and maintenance neuropathic pain has been confirmed. Previous studies have reported that miR138 neuroprotective anti-inflammatory effects animal models spinal cord injury human coronary artery endothelial cell injury, while its effect on is still not known. As mechanism remains unclear, we investigated whether involved development modulation a mouse model induced by spared sciatic nerve (SNI). Firstly, expression was evaluated days 1, 3, 5,...