A5102877679- Autophagy in Disease and Therapy
- NF-κB Signaling Pathways
- Signaling Pathways in Disease
- Traffic control and management
- RNA Research and Splicing
- Traffic and Road Safety
- Traffic Prediction and Management Techniques
- Hippo pathway signaling and YAP/TAZ
- Traditional Chinese Medicine Analysis
- Inflammasome and immune disorders
- Financial Risk and Volatility Modeling
- Natural product bioactivities and synthesis
- Anomaly Detection Techniques and Applications
- Cancer-related gene regulation
- Transportation Planning and Optimization
- Time Series Analysis and Forecasting
- Gut microbiota and health
- interferon and immune responses
- Market Dynamics and Volatility
- Gout, Hyperuricemia, Uric Acid
- Autonomous Vehicle Technology and Safety
- Autoimmune and Inflammatory Disorders Research
- Medicinal plant effects and applications
- Alcohol Consumption and Health Effects
- Vehicle emissions and performance
Southern Medical University
2011-2024
Central South University
2013-2024
Third Affiliated Hospital of Southern Medical University
2024
Texas A&M University
2024
Southern University of Science and Technology
2024
Yue Bei People's Hospital
2024
Shantou University
2024
Broad Institute
2024
Guangdong Academy of Medical Sciences
2024
Guangdong Provincial People's Hospital
2024
Akkermansia muciniphila is one of the most dominant bacteria that resides on mucus layer intestinal tract and plays key role in human health, however, little known about its genomic content.Herein, we for first time characterized architecture A. based whole-genome sequencing, assembling, annotating 39 isolates derived from mouse feces. We revealed a flexible open pangenome currently consisting 5644 unique proteins. Phylogenetic analysis identified three species-level phylogroups exhibiting...
Macroautophagy/autophagy plays an important role in regulating cellular homeostasis and influences the pathogenesis of degenerative diseases. Tendinopathy is characterized by tendon degeneration inflammation. However, little known about selective autophagy tendinopathy. Here, we find that pristimerin (PM), a quinone methide triterpenoid, more effective treating tendinopathy than first-line drug indomethacin. PM inhibits AIM2 inflammasome alleviates inflammation during promoting autophagic...
Abstract Single crystal metal halide perovskites thin films are considered to be a promising optical, optoelectronic materials with extraordinary performance due their low defect densities. However, it is still difficult achieve large‐scale perovskite single‐crystal (SCTFs) tunable bandgap by vapor‐phase deposition method. Herein, the synthesis of CsPbCl 3(1– x ) Br 3 SCTFs centimeter size (1 cm × 1 cm) via reported. The composition can gradually tuned from = 0 1, leading corresponding...
Stringent control of type I interferon (IFN-I) signaling is critical to potent innate immune responses against viral infection, yet the underlying molecular mechanisms are still elusive. Here, we found that Van Gogh–like 2 (VANGL2) acts as an IFN-inducible negative feedback regulator suppress IFN-I during vesicular stomatitis virus (VSV) infection. Mechanistically, VANGL2 interacted with TBK1 and promoted selective autophagic degradation via K48-linked polyubiquitination at Lys 372 by E3...
Objectives . This study aimed to identify the active compounds in Oldenlandia diffusa (OD) decoction and absorbed into plasma, determine whether derived from OD exerted any anti‐inflammatory effects rats with collagen induced arthritis (CIA). Methods The UPLC‐PDA (Ultra Performance Liquid Chromatography Photo‐Diode Array) method was applied both rat plasma. absorbable compound administered CIA rats, were dynamically observed. X‐ray films of joints HE stain synovial tissues analyzed. levels...
Although historical crash data and trajectory have been widely applied to risk predictions, both types of their own limitations. As a solution, this study investigates the impact traffic flow parameters interaction terms on prediction performance, employing variable pre-screening approach (i.e. Smoothly Clipped Absolute Deviation (SCAD)). A research framework is proposed for more efficient prediction, detailed case further conducted using approach. In study, real vehicle from HighD are...
Innate immunity acts as the first line of defense against pathogen invasion. During Toxoplasma gondii infection, multiple innate immune sensors are activated by invading microbes or pathogen-associated molecular patterns (PAMPs). However, how inflammasome is and its regulatory mechanisms during T. infection remain elusive. Here, we showed that PRU, a lethal type II strain, activates at early stage infection. PRU tachyzoites, RNA soluble tachyzoite antigen (STAg) mainly triggered NLRP3...
Rheumatoid arthritis (RA) is a chronic disabling autoimmune disease with characteristics of chronic, progressive inflammatory joint synovial damage, which mainly encroaches upon the synovium joint. The use traditional medicine to treat RA slows development certain extent; however, it often has numerous side-effects. Therefore, focus research identification new, safe and effective medicine. aim present study was an ultra performance liquid chromatography photo diode array (UPLC-PDA) method...
Abstract Synovial macrophage polarization and inflammation are essential for osteoarthritis (OA) development, yet the molecular mechanisms regulation responsible pathogenesis still poorly understood. Here, we report that pseudolaric acid B (PAB) attenuated articular cartilage degeneration synovitis during OA. PAB, a diterpene acid, specifically inhibited NF‐κB signalling reduced production of pro‐inflammatory cytokines, which further decreased M1 vessel formation. We provide in vivo vitro...
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of The nuclear factor-kappaB (NF-κB) signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( ΔM ) are...
Intelligent connected vehicles (ICVs) are recognized as a new sustainable transportation mode, which could be promising for reducing crashes. However, the mixed traffic consisting of manually driven and ICVs may negatively affect road safety due to individual heterogeneity. This study investigated heterogeneity effects on freeway safety-based simulation experiments. Two types vehicle dynamic models were employed depict behaviors adaptive cruise control (ACC) (a simplified version ICVs),...
Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of The nuclear factor-kappaB (NF-κB) signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( ΔM ) are...
Castration-resistant prostate cancer (CRPC) is the lethal form of (PCa), and underlying molecular mechanism has not been fully elucidated. Inositol requiring enzyme 1 alpha (IRE1α), a key regulator unfolded protein response (UPR), intimately associated with PCa progression. However, whether IRE1α implicated in CRPC development remains unknown. Here, we showed that expression was significantly increased tissues high-grade tissues. Overexpression promoted cell proliferation under androgen...
Van Gogh-like 2 (Vangl2), a core planar cell polarity (PCP) component, plays an important role in polarized cellular and tissue morphology induction, growth development cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of NF-κB signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( Δ M ) are hypersusceptible to...
To judge whether the connected and automated vehicles (CAVs) could perform better than human, this study proposes two methods to identify perception-reaction time (PRT) of human drivers using vehicle trajectory data - calibrated-based duration-based methods. The method utilises an intelligent driver model (IDM) capture longitudinal driving behaviours delineate PRT as a parameter. While approach collects by manually extracting value based on data. investigate factors influencing these types...
Van Gogh-like 2 (Vangl2), a core planar cell polarity (PCP) component, plays an important role in polarized cellular and tissue morphology induction, growth development cancer. However, its regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated patients with sepsis identify as negative regulator of NF-κB signaling by the protein stability activation transcription component p65. Mice myeloid-specific deletion ( Δ M ) are hypersusceptible to...