A5025380580- Autophagy in Disease and Therapy
- Curcumin's Biomedical Applications
- Immune Cell Function and Interaction
- Radiopharmaceutical Chemistry and Applications
- Cancer Mechanisms and Therapy
- Viral Infections and Outbreaks Research
- Liver Disease and Transplantation
- Organ Transplantation Techniques and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Immunodeficiency and Autoimmune Disorders
- Immune Response and Inflammation
- Nanoplatforms for cancer theranostics
- Signaling Pathways in Disease
- Tannin, Tannase and Anticancer Activities
- Transplantation: Methods and Outcomes
- Cell death mechanisms and regulation
- PI3K/AKT/mTOR signaling in cancer
- Neurological Disease Mechanisms and Treatments
- HIV Research and Treatment
- Advanced Nanomaterials in Catalysis
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Extracellular vesicles in disease
- Mosquito-borne diseases and control
- Drug-Induced Hepatotoxicity and Protection
Nankai University
2021-2024
Tianjin First Center Hospital
2019-2023
Tianjin Medical University
2019-2023
National Health and Family Planning Commission
2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2019
Tianjin University
2015
To create a more precise, efficient imaging and therapeutic strategy is big challenge for the current treatment of hepatocellular carcinoma (HCC). Photothermal therapy (PTT) has attracted enormous attention due to its non-invasive property precise spatial temporal control. Here, we developed realize superior performance treatment, utilizing an indocyanine green (ICG) sorafenib (S) co-loaded mesoporous silica nanosystem synergetic PTT/immuno-enhanced therapy. We proved that (ICG+S)@mSiO2...
Severe fever with thrombocytopenia syndrome virus (SFTSV) is a tick-borne pathogen that causes severe hemorrhagic fever. Although SFTSV poses serious threat to public health and was recently isolated, its pathogenesis remains unclear. In particular, the relationship between infection host cell cycle has not been described. Here, we show for first time both asynchronized synchronized SFTSV-susceptible cells arrest at G 2 /M checkpoint following accumulation of this facilitates viral...
Capecitabine (CAP) is now widely used in the comprehensive treatment of digestive system tumors. Some clinical observations have shown that CAP may immunosuppressive effects, but there still a lack clear experimental verification. In this study, different doses were administered to normal mice by gavage. Our results confirmed did not cause myelosuppression bone marrow tissue; selectively reduced proportion T cells and concentration related pro-inflammatory cytokines, while it increased...
Transplant oncology is a newly emerging discipline integrating oncology, transplant medicine, and surgery has brought malignancy treatment into new era via transplantation. In this context, obtaining drug with both immunosuppressive antitumor effects can take account the dual needs of preventing rejection tumor recurrence in liver transplantation patients malignancies. Capecitabine (CAP), classic drug, been shown to induce reactive oxygen species (ROS) production apoptosis cells. Meanwhile,...
Sterile α-motif/histidine-aspartate domain-containing protein (SAMHD1), a homo-tetrameric GTP/dGTP-dependent dNTP triphosphohydrolase, catalyzes the conversion of into deoxynucleoside and triphosphate. As only characterized triphosphohydrolase in human cells, SAMHD1 plays an important role innate immunity, autoimmunity, cell cycle control. Previous biochemical studies crystal structures have revealed that interconverts between inactive monomeric or dimeric form dGTP/GTP-induced active...
Hepatic ischemia reperfusion injury (IRI) is a risk factor for early graft nonfunction and rejection after liver transplantation (LT). The process of IRI involves inflammatory response, oxidative stress, apoptosis other pathophysiological processes. So far, there still lack effective drugs to ameliorate IRI. Trans-anethole (TA) an aromatic compound. Many medications as well natural foods contain TA. TA has multiple effects such anti-inflammation, anti-oxidative stress anti-apoptosis....
Hepatic ischemia - reperfusion injury (HIRI) is a major cause of postoperative complications and mortality after hepatobiliary surgery, but there currently no effective treatment strategy. Dogwood valuable Chinese Medicine which helps to protect the liver. Our animal experiments showed that ethanol extract (DD) could significantly lower levels Aspartate aminotransferase (AST) Alanine (ALT) in HIRI mice serum. The findings revealed DD had protective effect against mice. Furthermore, we used...
Objective To explore the changes and significance of hepatic cytokines during ischemia reperfusion in rats undergoing donation after circulatory death (DCD) liver transplantation different functional warm ischemic durations. Methods Maastricht Ⅲ DCD was simulated a rat model established. established by cutting diaphragm. There were four groups 0/15/30 min living donor control. Liver tissues serum samples obtained acquisition 6-hour respectively. Luminex liquid chip employed for...